Intranasal formulations: promising strategy to deliver vaccines

Intranasal Drug Delivery: How, Why and What for?

(2016) Anaísa Pires et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers

(2014) Rigmor Thorstensson et al.   PLoS One

Intranasal Vaccination Promotes Detrimental Th17-Mediated Immunity against Influenza Infection

(2014) Asher Maroof et al.   PLoS Pathogens

Vaccine Adjuvants: Key Tools for Innovative Vaccine Design

(2013) Peggy Riese et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Influenza virosomes as vaccine adjuvant and carrier system

(2013) Christian Moser et al.   Expert Review of Vaccines

Co-delivery of viral proteins and a TLR7 agonist from polysaccharide nanocapsules: A needle-free vaccination strategy

(2013) Sara Vicente et al.   JOURNAL OF CONTROLLED RELEASE

Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity

(2013) K. M. Quinn et al.   JOURNAL OF IMMUNOLOGY

Gold nanoparticle–M2e conjugate coformulated with CpG induces protective immunity against influenza A virus

(2013) Wenqian Tao et al.   Nanomedicine

Evaluation of In Vitro Cross-Reactivity to Avian H5N1 and Pandemic H1N1 2009 Influenza Following Prime Boost Regimens of Seasonal Influenza Vaccination in Healthy Human Subjects: A Randomised Trial

(2013) Delia Bethell et al.   PLoS One

Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes

(2013) Geert Leroux-Roels et al.   PLoS One

Evaluation of an Intranasal Virosomal Vaccine against Respiratory Syncytial Virus in Mice: Effect of TLR2 and NOD2 Ligands on Induction of Systemic and Mucosal Immune Responses

(2013) Muhammad Shafique et al.   PLoS One

Evaluation of the Effectiveness and Safety of Chitosan Derivatives as Adjuvants for Intranasal Vaccines

(2013) Takashi Kobayashi et al.   VIRAL IMMUNOLOGY

Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis

(2013) E. Miller et al.   BMJ-British Medical Journal

A post-marketing surveillance study of a human live-virus pandemic influenza A (H1N1) vaccine (Nasovac®) in India

(2013) Prasad S. Kulkarni et al.   Human Vaccines & Immunotherapeutics

Mucosal Vaccine Design and Delivery

(2012) Kim A. Woodrow et al.   Annual Review of Biomedical Engineering

M cell targeting by a Claudin 4 targeting peptide can enhance mucosal IgA responses

(2012) David D Lo et al.   BMC BIOTECHNOLOGY

Intranasal vaccination with an adjuvanted Norwalk virus-like particle vaccine elicits antigen-specific B memory responses in human adult volunteers

(2012) Karina Ramirez et al.   CLINICAL IMMUNOLOGY

Differential serum cytokine responses to inactivated and live attenuated seasonal influenza vaccines

(2012) Amritha Ramakrishnan et al.   CYTOKINE

Chitosan-based delivery systems for mucosal vaccines

(2012) Inderjit Jabbal-Gill et al.   Expert Opinion on Drug Delivery

A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine

(2012) Signe C. Svindland et al.   Influenza and Other Respiratory Viruses

Liposome-based delivery system for vaccine candidates: constructing an effective formulation

(2012) Ashwini Kumar Giddam et al.   Nanomedicine

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

NKT Cell Stimulation with α-Galactosylceramide Results in a Block of Th17 Differentiation after Intranasal Immunization in Mice

(2012) Beata M. Zygmunt et al.   PLoS One

Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 Agonist, Promotes Potent Systemic and Mucosal Responses to Intranasal Immunization with HIVgp140

(2012) Mauricio A. Arias et al.   PLoS One

Evaluation of TLR Agonists as Potential Mucosal Adjuvants for HIV gp140 and Tetanus Toxoid in Mice

(2012) Viviana Buffa et al.   PLoS One

The safety and effectiveness of self-administration of intranasal live attenuated influenza vaccine in adults

(2012) Christopher S. Ambrose et al.   VACCINE

Risk of presentation to hospital with epileptic seizures after vaccination with monovalent AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine (Pandemrix): self controlled case series study

(2012) L. Arnheim-Dahlstrom et al.   BMJ-British Medical Journal

Inside the Mucosal Immune System

(2012) Jerry R. McGhee et al.   PLOS BIOLOGY

Strategies for intranasal delivery of vaccines

(2012) Mehfuz Zaman et al.   Drug Delivery and Translational Research

Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination

(2012) Sae-Hae Kim et al.   Immune Network

Live Attenuated Influenza Vaccine (FluMist®; Fluenz™)

(2011) Natalie J. Carter et al.   DRUGS

Intranasal but not intravenous delivery of the adjuvant α-galactosylceramide permits repeated stimulation of natural killer T cells in the lung

(2011) Amy N. Courtney et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery

(2011) Sae-Hae Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Monophosphoryl lipid A induced innate immune responses via TLR4 to enhance clearance of nontypeableHaemophilus influenzaeandMoraxella catarrhalisfrom the nasopharynx in mice

(2011) Takashi Hirano et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Safety and Immunogenicity of Live Attenuated and Inactivated Influenza Vaccines in Children With Cancer

(2011) Silvana Carr et al.   JOURNAL OF INFECTIOUS DISEASES

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Norovirus Vaccine against Experimental Human Norwalk Virus Illness

(2011) Robert L. Atmar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 1 Study of the Safety and Immunogenicity of a Live, Attenuated Respiratory Syncytial Virus and Parainfluenza Virus Type 3 Vaccine in Seronegative Children

(2011) David I. Bernstein et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Outer Membrane Vesicles of Porphyromonas gingivalis Elicit a Mucosal Immune Response

(2011) Ryoma Nakao et al.   PLoS One

A pandemic influenza vaccine in India: From strain to sale within 12 months

(2011) Rajeev Dhere et al.   VACCINE

Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant

(2011) Thomas Ebensen et al.   VACCINE

Safety and immunogenicity of an intranasal Shigella flexneri 2a Invaplex 50 vaccine

(2011) Mark S. Riddle et al.   VACCINE

A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus

(2011) Dubravka Grdic Eliasson et al.   VACCINE

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice

(2011) Abdullah S. Madhun et al.   VACCINE

Edward Jenner and the Small Pox Vaccine

(2011) Kendall A. Smith   Frontiers in Immunology

An Intranasally Delivered Toll-Like Receptor 7 Agonist Elicits Robust Systemic and Mucosal Responses to Norwalk Virus-Like Particles

(2010) L. S. Velasquez et al.   Clinical and Vaccine Immunology

The crucial role of dendritic cells in rhinitis

(2010) Alex KleinJan   Current Opinion in Allergy and Clinical Immunology

Biphasic Vesicles: A Novel Topical Drug Delivery System

(2010) Marianna Foldvari   Journal of Biomedical Nanotechnology

Chitosan Modification and Pharmaceutical/Biomedical Applications

(2010) Jiali Zhang et al.   Marine Drugs

Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins

(2010) N Lycke et al.   Mucosal Immunology

Intranasal Immunization with Influenza VLPs Incorporating Membrane-Anchored Flagellin Induces Strong Heterosubtypic Protection

(2010) Bao-Zhong Wang et al.   PLoS One

Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: Nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen

(2010) Bram Slütter et al.   VACCINE

TLR-based immune adjuvants

(2010) Folkert Steinhagen et al.   VACCINE

Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells

(2010) Ali Azizi et al.   PLoS Pathogens

PEG–PLA–PEG block copolymeric nanoparticles for oral immunization against hepatitis B

(2009) Arvind K. Jain et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Synthesis, characterization and evaluation of novel triblock copolymer based nanoparticles for vaccine delivery against hepatitis B

(2009) Arvind K. Jain et al.   JOURNAL OF CONTROLLED RELEASE

CD11c+CD8 + Dendritic Cells Promote Protective Immunity to Respiratory Infection with Bordetella pertussis

(2009) P. J. Dunne et al.   JOURNAL OF IMMUNOLOGY

Intranasal Immunization Promotes Th17 Immune Responses

(2009) B. M. Zygmunt et al.   JOURNAL OF IMMUNOLOGY

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin

(2009) David J. M. Lewis et al.   PLoS One

Effect of lipopolysaccharide on intranasal administration of liposomal Newcastle disease virus vaccine to SPF chickens

(2009) Li-Ping Tseng et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model

(2008) Silvia I. Cazorla et al.   VACCINE