Article
Public, Environmental & Occupational Health
Kumiko O. Schnock, Sara E. Rostas, Catherine S. Yoon, Stuart Lipsitz, David W. Bates, Patricia C. Dykes
Summary: This study investigated intravenous medication administration errors in the NICU using smart infusion pumps. A total of 441 patients with 905 IV medication administrations were observed, and 130 errors were identified. The most frequent errors were selecting the wrong drug library entry, unauthorized medication, and wrong dose. 68 errors were unlikely to cause harm to patients, while the rest did not reach the patient.
Article
Anesthesiology
Eun Jung Oh, Kwan Young Hong, Jong-Hwan Lee, Duk Kyung Kim, Joongbum Cho, Jeong-Jin Min
Summary: This study compared flow rate variability between different types of infusion pumps and found that the novel cylinder pump demonstrated more stability and fewer errors in microinfusion settings.
ANESTHESIA AND ANALGESIA
(2022)
Article
Allergy
Stephanie Stojanovic, Linda Graudins, Ar Kar Aung, Louise Grannell, Mark Hew, Celia Zubrinich
Summary: The study found that recommencement of the index infusion is safe for Fishbane symptoms or mild to moderate hypersensitivity reactions. Subsequent rechallenge to an alternative formulation, including in cases of severe hypersensitivity reactions (although based on limited numbers), was also well tolerated. Rechallenge to the same formulation could be considered if alternative formulations are not available.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Computer Science, Information Systems
George Stergiopoulos, Panayiotis Kotzanikolaou, Charalambos Konstantinou, Achilleas Tsoukalis
Summary: This article discusses the vulnerability of medical infusion pumps to cyber threats and highlights the lack of research on securing these devices against process-aware attacks. The authors develop a threat model and conduct simulations to validate attack models that can cause adverse effects on patients through performance degradation of drug administration processes.
IEEE SYSTEMS JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Anne Geraldine Guex, David J. Poxson, Daniel T. Simon, Magnus Berggren, Giuseppino Fortunato, Rene M. Rossi, Katharina Maniura-Weber, Markus Rottmar
Summary: This study proposes a method to manipulate fibroblast to myofibroblast differentiation by controlling the pH of the cellular microenvironment using electronic ion pump technology, leading to reduced expression of scar-related markers and promoting scar-free wound healing.
APPLIED MATERIALS TODAY
(2021)
Article
Public, Environmental & Occupational Health
Adam Sutherland, Matthew D. Jones, Moninne Howlett, Sara Arenas-Lopez, Arif Patel, Bryony Dean Franklin
Summary: Standardizing infusion concentrations, developing and implementing drug libraries, establishing standardized metrics, involving all stakeholders in development, and leveraging input into device design are key strategic recommendations to support the implementation of medication administration technology for improving medication safety.
Article
Pharmacology & Pharmacy
Kamelia Krysiak, Brian Cleary, Naomi McCallion, Fiona O'Brien
Summary: This study investigated the drug delivery rate through a multi-infusion system in premature neonates. The results showed that delayed drug delivery in this system may lead to dosing errors.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
John D. Ayres, Hanns-Christian Mahler
Summary: The use of in-line filters in intravenous fluid administration dates back to the early 1830s, but assessing the filter components, their interactions with drug products, and the impact on clinical outcomes remains a challenge. While some well-defined therapeutic settings may benefit from in-line filtration, the majority of observational studies do not provide enough scientific support for broad-based routine use. Ultimately, the decision on filter use falls on healthcare providers based on available information.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Florian Wieduwilt, Jasmin Gruenewald, Georgios Ctistis, Christoph Lenth, Thorsten Perl, Hainer Wackerbarth
Summary: Incorrect medication administration causes millions of undesirable complications worldwide annually. This study proposes an alarm sensor based on UV-Vis spectroscopy and refractometry, which are non-invasive and non-destructive methods. They can be used for quantification of dissolved analytes in transparent substances and are capable of discerning standard medications used in intensive care medicine.
Article
Chemistry, Multidisciplinary
Xin Li, Holmfridur R. Halldorsdottir, Sven Weller, Anna Colliander, Martin Bak, Paul Kempen, Gael Clergeaud, Thomas L. Andresen
Summary: Although adoptive T cell therapy for cancer treatment has limitations, loading T cells with SHP099 can enhance therapeutic efficacy. Cell-loaded SHP099 enables sustained inhibition of the PD-1/PD-L1 signaling and increases cytolytic activity of the T cells. This is a promising therapeutic strategy.
Article
Engineering, Electrical & Electronic
Mizuki Ikeda, Satomitsu Imai
Summary: We have created and tested a prototype micro-pump that relies on a chemical reaction to drive medication delivery. The reaction between citric acid and sodium bicarbonate generates carbon dioxide, which then pushes the medication out. This smaller alternative to diaphragm-type micropumps can be easily swallowed.
IEICE TRANSACTIONS ON ELECTRONICS
(2023)
Article
Pharmacology & Pharmacy
Laura M. de Jong, Soukayna Boussallami, Elena Sanchez-Lopez, Martin Giera, Maarten E. Tushuizen, Menno Hoekstra, Lukas J. A. C. Hawinkels, Robert Rissmann, Jesse J. Swen, Martijn L. Manson
Summary: The CYP2C19 genotype has an impact on the outcome of CYP2C19-dependent drug-drug interactions (DDIs), but there is substantial inconsistency between predicted and observed phenotypes, which may be influenced by disease-related factors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
James B. Machamer, Edwin J. Vazquez-Cintron, Sean W. O'Brien, Kyle E. Kelly, Amber C. Altvater, Kathleen T. Pagarigan, Parker B. Dubee, Celinia A. Ondeck, Patrick M. McNutt
Summary: Continuous infusion of 3,4-diaminopyridine (3,4-DAP) can sustain symptomatic benefits in the course of botulism and reverse systemic paralysis, promoting survival.
MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Michael McPeck, Gerald C. Smaldone
Summary: This paper reviews the background, current methods, challenges, and limitations of aerosol delivery of epoprostenol in critically ill mechanically ventilated patients. A recent advance in bench testing using radiolabeled aerosols is presented to reveal important factors defining delivery. The off-label use of continuously nebulized prostacyclin in the ICU lacks support from large clinical trials, but bench studies can provide insight for better therapy management.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Engineering, Biomedical
Kathleen Marulanda, Alexandra Mercel, David C. Gillis, Kui Sun, Maria Gambarian, Joshua Roark, Jenna Weiss, Nick D. Tsihlis, Mark R. Karver, S. Ruben Centeno, Erica B. Peters, Tristan D. Clemons, Samuel I. Stupp, Sean E. McLean, Melina R. Kibbe
Summary: The study developed peptide amphiphile nanofibers that target lung tissue with pulmonary hypertension, demonstrating the potential of a RAGE-targeted nanomaterial as a drug delivery platform to treat the disease. The targeted nanofibers significantly accumulated in the lungs, showing specific localization to diseased pulmonary tissue and reduced off-target toxicity.
ADVANCED HEALTHCARE MATERIALS
(2021)