Latent cytokines for targeted therapy of inflammatory disorders

Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide

(2012) Sarah E Wythe et al.   ANNALS OF THE RHEUMATIC DISEASES

The Antibody-Based Delivery of Interleukin-12 to the Tumor Neovasculature Eradicates Murine Models of Cancer in Combination with Paclitaxel

(2012) N. Pasche et al.   CLINICAL CANCER RESEARCH

Increased disulphide dimer formation of latent associated peptide fusions of TGF-β by addition of l-cystine

(2012) Lisa M. Mullen et al.   JOURNAL OF BIOTECHNOLOGY

Selective Domain Stabilization as a Strategy to Reduce Human Serum Albumin–Human Granulocyte Colony Stimulating Factor Aggregation Rate

(2012) Amanda A. Cordes et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Selective Targeting of Interferon   to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth

(2012) R. Bansal et al.   MOLECULAR CANCER THERAPEUTICS

The targeted delivery of IL17 to the mouse tumor neo-vasculature enhances angiogenesis but does not reduce tumor growth rate

(2011) Nadine Pasche et al.   ANGIOGENESIS

Molecular engineering of short half-life small peptides (VIP, αMSH and γ3MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics

(2011) Sandrine Vessillier et al.   ANNALS OF THE RHEUMATIC DISEASES

A Phase 1 Study of AS1409, a Novel Antibody-Cytokine Fusion Protein, in Patients with Malignant Melanoma or Renal Cell Carcinoma

(2011) S. M. Rudman et al.   CLINICAL CANCER RESEARCH

Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice

(2011) Ruchi Bansal et al.   HEPATOLOGY

The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model

(2011) Kathrin Schwager et al.   HUMAN REPRODUCTION

Cloning and characterization of novel tumor-targeting immunocytokines based on murine IL7

(2011) Nadine Pasche et al.   JOURNAL OF BIOTECHNOLOGY

Enhanced Expression of CD13 in Vessels of Inflammatory and Neoplastic Tissues

(2011) Paola Di Matteo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Peptide-Modified Albumin Carrier Explored as a Novel Strategy for a Cell-Specific Delivery of Interferon Gamma To Treat Liver Fibrosis

(2011) Ruchi Bansal et al.   MOLECULAR PHARMACEUTICS

Human single-chain variable fragment that specifically targets arthritic cartilage

(2010) Chris Hughes et al.   ARTHRITIS AND RHEUMATISM

Influence of carbohydrates on the stability and structure of a hyperglycosylated human interferon alpha mutein

(2010) Natalia Ceaglio et al.   BIOCHIMIE

Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12

(2010) Roberto Sommavilla et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Anti-serum albumin domain antibodies in the development of highly potent, efficacious and long-acting interferon

(2010) A. Walker et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Elimination of the free sulfhydryl group in the human serum albumin (HSA) moiety of human interferon-α2b and HSA fusion protein increases its stability against mechanical and thermal stresses

(2009) Hong Liang Zhao et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Production and characterization of long-acting recombinant human albumin–EPO fusion protein expressed in CHO cell

(2009) Chan-Hi Joung et al.   PROTEIN EXPRESSION AND PURIFICATION

Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis

(2009) Kathrin Schwager et al.   ARTHRITIS RESEARCH & THERAPY

The Impact of PEGylation on Biological Therapies

(2008) Francesco M Veronese et al.   BIODRUGS

A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculaturein vivo

(2008) Alessandra Villa et al.   INTERNATIONAL JOURNAL OF CANCER

Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs

(2008) L. J. Holt et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Cytokines and anti-cytokines as therapeutics — An update

(2007) Vandana Tayal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY