Review
Chemistry, Multidisciplinary
Saeid Moghassemi, Arezoo Dadashzadeh, Ricardo Bentes Azevedo, Olivier Feron, Christiani A. Amorim
Summary: Photodynamic therapy (PDT) combines photochemistry and photophysics sciences for cancer therapy, showing significant potential. Despite advantages and progress, common photosensitizing agents have limitations, which can be addressed by using liposomes as carriers for PS.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Ponien Kou, Elizabeth S. Levy, An D. Nguyen, Donglu Zhang, Shu Chen, Yusi Cui, Xing Zhang, Fabio Broccatelli, Jennifer Pizzano, Jennifer Cantley, Elizabeth Bortolon, Emma Rousseau, Michael Berlin, Peter Dragovich, Vijay Sethuraman
Summary: PROTACs, including monovalent and bivalent protein degraders, are a promising technology in drug development. The market entry of bivalent PROTACs has been limited due to their complex physicochemical properties. Encapsulation in liposome systems can improve the pharmacokinetics of PROTACs, as shown in studies of two bivalent PROTAC molecules.
Review
Biotechnology & Applied Microbiology
Yang-Bao Miao, Tianxing Xu, Ying Gong, Anmei Chen, Liang Zou, Tao Jiang, Yi Shi
Summary: Oral administration is the preferred method of drug delivery due to its safety and high patient compliance, but it is limited by poor bioavailability. This review discusses the targeted drug vehicles to the intestinal lymphatic system (ILS) and their significance in medication absorption and transport. The review presents various approaches to targeting the ILS for enhanced bioavailability and targeted delivery, as well as methods for opening the ILS window for potential clinical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shigeki Kato, Shota Yoshiba, Shiro Mori, Tetsuya Kodama
Summary: This study investigated the factors influencing drug delivery efficiency using LDDS with ultrasound, including injection rate, molecular weight, and administration route. The results showed that lower injection rate, smaller molecular weight, and administration into an upstream LN close to the target LN could improve delivery efficiency.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Christian A. Boada, Assaf Zinger, Scott Rohen, Jonathan O. Martinez, Michael Evangelopoulos, Roberto Molinaro, Madeleine Lu, Ramiro Alejandro Villarreal-Leal, Federica Giordano, Manuela Sushnitha, Enrica De Rosa, Jens B. Simonsen, Sergey Shevkoplyas, Francesca Taraballi, Ennio Tasciotti
Summary: Apolipoprotein-based drug delivery using lipid-based nanoparticles called Aposomes shows promising potential for targeted drug delivery. These Aposomes, with native apoB-100 protein on the surface, demonstrated active drug loading capabilities and enhanced targeting towards atherosclerotic plaques in a mouse model. The study highlights the feasibility of utilizing apolipoprotein-based approaches to create nanoparticles with active targeting capabilities for potential cardiovascular therapies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Taranom Mobasheri, Elham Rayzan, Mahsima Shabani, Mina Hosseini, Ghanbar Mahmoodi Chalbatani, Nima Rezaei
Summary: Research focuses on developing new therapeutic strategies for neuroblastoma, targeting different genes and utilizing nano-drug delivery systems to improve treatment efficacy. The combination of specific drug targets and nano-drug delivery systems may lead to lower systemic side effects and improved therapeutic effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Engineering, Biomedical
Laura Alderfer, Eva Hall, Donny Hanjaya-Putra
Summary: This article highlights the importance of using biomaterials to study the lymphatic system, emphasizing their potential roles in immune cell trafficking, drug delivery, and tissue regeneration. Insights gained from mechanistic studies can be applied to design innovative biomaterials for immunomodulation and future therapeutic strategies.
ACTA BIOMATERIALIA
(2021)
Review
Pharmacology & Pharmacy
Diana Guimaraes, Artur Cavaco-Paulo, Eugenia Nogueira
Summary: Liposomes are effective drug delivery systems that improve therapeutic efficacy, being nontoxic and biodegradable. Key aspects such as design, production techniques, drug loading, and characterization for in vitro and in vivo performance are essential for successful liposomal formulations. Other topics explored include functionalization, targeting strategies, stability, limitations, and current market applications of liposomes in various therapeutic fields.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Rumiana Tenchov, Robert Bird, Allison E. Curtze, Qiongqiong Zhou
Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.
Article
Biochemistry & Molecular Biology
Joseph Jose, Hemalatha Kanniyappan, Vignesh Muthuvijayan
Summary: This study presents a novel approach for separating drugs from liposomes using solvents with varying dielectric constants. The method proves to be cost-effective and efficient, with a significantly higher recovery rate compared to conventional techniques.
PROCESS BIOCHEMISTRY
(2022)
Article
Infectious Diseases
Patricia M. Graves, Sarah Sheridan, Jessica Scott, Filipina Amosa-Lei Sam, Take Naseri, Robert Thomsen, Christopher L. King, Colleen L. Lau
Summary: After the first triple-drug mass drug administration (MDA) for lymphatic filariasis in Samoa in 2018, unexpected persistence of microfilaria (Mf) positivity was observed in a nationwide household survey, raising concerns about MDA efficacy. However, a monitored treatment study in 2019 showed that the triple-drug MDA strategy was effective at clearing Mf when given and taken at the correct dose.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
Review
Cell Biology
Nabarun Chandra Das, Pritha Chakraborty, Samapika Nandy, Abhijit Dey, Tabarak Malik, Suprabhat Mukherjee
Summary: More than 50 years have passed since the start of the National Filariasis Control Program, but lymphatic filariasis (LF) remains prevalent globally, especially in tropical and subtropical regions, posing a major challenge to global elimination efforts. LF affects humans and economically important livestock, contributing significantly to morbidity and disabilities. Developing effective therapeutics and strategies against the adult stage of filarial nematodes has become crucial. Apoptosis has emerged as a promising target for developing antifilarial drugs, as it induces filarial death through reactive oxygen species (ROS) signals and intrinsic and extrinsic pathways. Various natural and synthetic compounds/nanoformulations have shown efficacy in triggering apoptotic death in filarial parasites with minimal toxicity to the host body.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Dermatology
Soraya Babaie, Mohammad Charkhpour, Maryam Kouhsoltani, Hamed Hamishehkar, Ana Claudia Paiva-Santos
Summary: By using lipid-based nanovesicles, buprenorphine and bupivacaine can be co-delivered to effectively target pain receptors concentrated in the skin, resulting in potent dermal anesthesia.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Immunology
Estelle Remion, Josephine Gal, Soraya Chaouch, Jules Rodrigues, Nathaly Lhermitte-Vallarino, Joy Alonso, Linda Kohl, Marc P. Huebner, Frederic Fercoq, Coralie Martin
Summary: This study investigated the role of Th2 immune response in regulating filarial infections using the rodent filaria Litomosoides sigmodontis. The study found that Th2 deficient mice showed sustained high microfilarial viremia after infection, but pleuropulmonary pathologies were significantly reduced. Additionally, the presence of both microfilariae and IL-4R/IL-5 signaling were crucial for the development of the pathology and phenotype of macrophages.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Jin Huang, Dandan Zhao, Chaojing Cui, Jianxiong Hao, Zhentao Zhang, Limin Guo
Summary: Phenylethanoid glycosides have strong biological activities, but the delivery systems face challenges such as lack of uniform standards and poor targeted delivery accuracy, requiring further research and development to address these issues.
Article
Plant Sciences
Farhan Ahmad, Aisha Kamal, Ananya Singh, Farha Ashfaque, Saud Alamri, Manzer H. Siddiqui
Summary: This study evaluated the effect of seed priming with salicylic acid (SA) on reducing the adverse effects of salt stress in pea seedlings. The results showed that seed priming with SA alleviated the negative impact of salinity on overall plant performance, including growth and photosynthetic attributes. SA achieved this by inducing enzymatic and non-enzymatic antioxidant systems, promoting soluble sugar and proline accumulation, and regulating ion homeostasis. Seed priming with SA could be a promising approach for cultivating salt-tolerant plants.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Review
Environmental Sciences
Sima Singh, Arshid Numan, Dinesh Sharma, Rahul Shukla, Amit Alexander, Gaurav Kumar Jain, Farhan Jalees Ahmad, Prashant Kesharwani
Summary: The outbreak of the COVID-19 pandemic in 2019 and 2020 has led to a new era of communicable infectious diseases, with the emergence of Hantavirus infection posing a new public health emergency. Hantavirus, a zoonotic pathogen, causes two major clinical manifestations - HFRS and HCPS. Despite the lack of effective treatments or vaccines, public awareness and precautionary measures can help reduce the spread of the virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Biochemical Research Methods
S. M. Kawish, Abdul Qadir, Suma Saad, Sarwar Beg, Gaurav K. Jain, Mohd Aqil, Amer M. Alanazi, Azmat Ali Khan, Md Abdur Rashid, Rehan A. Rab, Waleed H. Almalki, Farhan J. Ahmad
Summary: A cost-effective, reliable, and rapid HPTLC method was developed for estimating GLA in borage oil, utilizing aluminum plates precoated with silica gel as the stationary phase and a hexane:toulene:glacial acetic acid mixture as the mobile phase. The method showed well-resolved spots for GLA and was validated for parameters like linearity, accuracy, specificity, and precision. The method demonstrated high sensitivity for GLA estimation in herbal oil samples and formulations.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Mansi Budhiraja, Sobiya Zafar, Sohail Akhter, Majed Alrobaian, Md Abdur Rashid, Md. Abul Barkat, Sarwar Beg, Farhan J. Ahmad
Summary: This study developed a combinational drug delivery system by embedding mupirocin-loaded chitosan microspheres in a collagen scaffold containing Piper betle extract, aiming to improve wound healing. The results showed that this method effectively promoted wound healing and exhibited good antibacterial effects.
Article
Engineering, Chemical
Muzaffar Iqbal, Mohammad Raish, Ajaz Ahmad, Essam A. Ali, Yousef A. Bin Jardan, Mushtaq A. Ansari, Mudassar Shahid, Abdul Ahad, Khalid M. Alkharfy, Fahad I. Al-Jenoobi
Summary: The study found that when Ibrutinib interacts with Sinapic acid, it may influence the pharmacokinetics of Ibrutinib and result in increased bioavailability. This may be due to the inhibition of IBR metabolism in the liver and intestines by SA.
Review
Biochemistry & Molecular Biology
Syed M. Kawish, Shwetakshi Sharma, Waleed H. Almalki, Saad Alghamdi, Obaid Afzal, Imran Kazmi, Abdulmalik S. A. Altamimi, Fahad A. Al-Abbasi, Sarwar Beg, Farhan J. Ahmad
Summary: The pharmaceutical industry is advancing towards personalized medicine through innovation in drug development. Three-dimensional printing technology has enabled the manufacturing of personalized dosage forms, opening up new possibilities for discovering compounds and technologies.
CURRENT DRUG METABOLISM
(2022)
Article
Food Science & Technology
Sarushi Rastogi, Vinita Kumari, Vasudha Sharma, Farhan Jalees Ahmad
Summary: A colorimetric method was developed for visual detection of oxytocin in bottle gourd. The method showed high sensitivity and a quick reaction time, allowing for accurate screening of oxytocin.
FOOD ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Rehan A. Rub, Sagar Suman Panda, Sunil K. Panda, Waleed H. Almalki, Majed Alrobaian, Abdul Hafeez, Mahfoozur Rahman, Sarwar Beg, Asgar Ali, Farhan J. Ahmed
Summary: The research focuses on developing an analytical method for estimating aripiprazole in rat plasma using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Propranolol was chosen as the internal standard for maximum recovery of the drug from rat plasma during pharmacokinetic evaluation.
SEPARATION SCIENCE PLUS
(2022)
Article
Engineering, Biomedical
Saman Fatima, Mubashshir Ali, Syed Naved Quadri, Sarwar Beg, M. Samim, Suhel Parvez, Malik Zainul Abdin, Prashant Mishra, Farhan Jalees Ahmad
Summary: The study reported the use of nanoparticles to enhance the targeting and bioavailability of ropinirole hydrochloride for the treatment of ischemic stroke. The nanoparticles showed improved therapeutic effects and reduced unwanted toxicities. Additionally, they were able to attenuate ischemic injury and restore neurological and behavioral deficits.
Editorial Material
Biochemistry & Molecular Biology
Md. Abul Barkat, Sarwar Beg, Farhan J. Ahmad
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
S. M. Kawish, Nazeer Hasan, Sarwar Beg, Abdul Qadir, Gaurav K. Jain, Mohd Aqil, Farhan J. Ahmad
Summary: In this study, a novel docetaxel-nanoemulsion was developed to improve therapeutic effectiveness and reduce side effects through targeted delivery. The optimized nanoemulsion demonstrated excellent characteristics in terms of drug encapsulation, drug release kinetics, and in vivo pharmacokinetics.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Pavitra Solanki, Mohd Danish Ansari, Mohd Iqbal Alam, Mohd Aqil, Farhan J. Ahmad, Yasmin Sultana
Summary: This study developed an orally effective nanoformulation of disodium pamidronate for the treatment of osteoporosis. Through rational design and optimization, a commercially potential self nano-emulsifying drug delivery system (SNEDDS) was developed, which showed improved oral bioavailability and enhanced anti-osteoporotic activity. The study provided significant achievements in the treatment of postmenopausal osteoporosis and may lead to the use of nanotherapeutic-driven emerging biodegradable carriers-based drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Farhan Ahmad, Shalini Singh, Niraj Kumari
Summary: Spontaneous regression (SR) is relatively rare in non-small-cell lung cancer, especially with adenocarcinoma histology. Various mechanisms have been postulated, but the exact underlying mechanism is still uncertain.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Arif Nadaf, Akash Gupta, Nazeer Hasan, Fauziya, Shadaan Ahmad, Prashant Kesharwani, Farhan J. Ahmad
Summary: Electrospinning is a versatile technique for generating ultrathin fibers, and this review provides a comprehensive overview of electrospinning and non-electrospinning processes, their setup, fabrication process, components, and applications. The review covers the characteristics of nanofibers, materials required for their production, and the diverse applications they have in various fields. It also discusses the challenges and future prospects of nanofiber development.
Article
Polymer Science
Mohammad Zubair Ahmed, Anshul Gupta, Musarrat Husain Warsi, Ahmed M. Abdelhaleem Ali, Nazeer Hasan, Farhan J. Ahmad, Ameeduzzafar Zafar, Gaurav K. Jain
Summary: Vitamin D deficiency is prevalent among nearly 50% of the global population, and this study developed a vitamin D oil-in-water nanoemulsion incorporated in edible gummies to enhance bioavailability and stability. The nanoemulsion prevented degradation of vitamin D and retained its activity over 15 days. The vitamin D gummies formulated with the nanoemulsion had optimal hardness and maintained taste and acceptance over 45 days of storage. This study highlights the potential of nanoemulsions to improve the delivery and effectiveness of vitamin D.