Clinical translation of folate receptor-targeted therapeutics

PRECEDENT: A randomized phase II trial comparing EC145 and pegylated liposomal doxorubicin (PLD) in combination, versus PLD alone, in subjects with platinum-resistant ovarian cancer.

(2017) R. W. Naumann et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I safety study of farletuzumab, carboplatin, and pegylated liposomal doxorubicin (PLD) in subjects with platinum-sensitive epithelial ovarian cancer (EOC).

(2017) D. Jelovac et al.   JOURNAL OF CLINICAL ONCOLOGY

Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance

(2015) Daniel J. O'Shannessy et al.   Oncotarget

EC145: a novel targeted agent for adenocarcinoma of the lung

(2012) Pamela Pribble et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Design, Synthesis, and Biological Functionality of a Dendrimer-Based Modular Drug Delivery Platform

(2011) Douglas G. Mullen et al.   BIOCONJUGATE CHEMISTRY

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

(2011) Gooitzen M van Dam et al.   NATURE MEDICINE

Folate-Immunoglobulin G as an Anticancer Therapeutic Antibody

(2010) Hong Li et al.   BIOCONJUGATE CHEMISTRY

Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2 homodimers in a clinic-based cohort of patients with metastatic breast cancer

(2010) Masakazu Toi et al.   BMC CANCER

Farletuzumab, a Humanized Monoclonal Antibody against Folate Receptor  , in Epithelial Ovarian Cancer: a Phase I Study

(2010) J. A. Konner et al.   CLINICAL CANCER RESEARCH

Farletuzumab in epithelial ovarian carcinoma

(2010) Whitney A Spannuth et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Folate-Targeted Therapies for Cancer

(2010) Wei Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reducing Undesirable Hepatic Clearance of a Tumor-Targeted Vinca Alkaloid via Novel Saccharopeptidic Modifications

(2010) C. P. Leamon et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

(2009) Joost W. Van Der Heijden et al.   ARTHRITIS AND RHEUMATISM

Folate Receptor   Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

(2009) A. Puig-Kroger et al.   CANCER RESEARCH

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

In Vivo Structural Activity and Optimization Studies of Folate−Tubulysin Conjugates

(2009) Joseph A. Reddy et al.   MOLECULAR PHARMACEUTICS

Expression Status of Folate Receptor α Is Significantly Correlated with Prognosis in Non-Small-Cell Lung Cancers

(2008) Shotaro Iwakiri et al.   ANNALS OF SURGICAL ONCOLOGY

Targeted drug delivery via folate receptors

(2008) Xiaobin Zhao et al.   Expert Opinion on Drug Delivery

Folate receptor alpha as a tumor target in epithelial ovarian cancer

(2008) Kimberly R. Kalli et al.   GYNECOLOGIC ONCOLOGY

Rationale for folate receptor alpha targeted therapy in “high risk” endometrial carcinomas

(2008) Monica Brown Jones et al.   INTERNATIONAL JOURNAL OF CANCER

Exploratory Study of 99mTc-EC20 Imaging for Identifying Patients with Folate Receptor-Positive Solid Tumors

(2008) R. E. Fisher et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical radioimmunotargeting of folate receptor alpha using the monoclonal antibody conjugate DOTA–MORAb-003

(2008) Peter M. Smith-Jones et al.   NUCLEAR MEDICINE AND BIOLOGY