Journal
EXPERT OPINION ON DRUG DELIVERY
Volume 9, Issue 11, Pages 1377-1392Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425247.2012.724396
Keywords
antioxidant activity; cyclodextrins; drug delivery systems; lipoamino acids; liposomes; microemulsions; nanoparticles; prodrugs; SLN; solid lipid nanoparticles
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Introduction: Idebenone (IDE) is an antioxidant compound, structurally related to coenzyme Q10. Its therapeutic potential is growing in different application areas, as demonstrated by the number of experimental works and patents produced in very recent years. Areas covered: Cyclodextrin inclusion complexes, liposomes, microemulsions, prodrugs, polymeric and lipid nanoparticles have been explored to achieve different goals, such as topical administration, brain targeting or increasing the bioavailability of this highly lipophilic drug. This review summarizes the results of works published in the last 20 years for the delivery and targeting of this drug. Expert opinion: A direct comparison of the different carrier systems is not easy and could not even be significant, due to the large variables existing among them. However, the different forms of delivery can help increase idebenone solubility, stability and biochemical activity. Further studies will be developed in order to improve the controlled release and targeting of idebenone.
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