Non-viral nanovectors for gene delivery: factors that govern successful therapeutics

Aptamers and aptamer targeted delivery

(2010) Amy C. Yan et al.   RNA Biology

Tissue-specific and transcription factor-mediated nuclear entry of DNA

(2009) Aaron M. Miller et al.   ADVANCED DRUG DELIVERY REVIEWS

Development of Antisense-Mediated Exon Skipping as a Treatment for Duchenne Muscular Dystrophy

(2009) Hans Heemskerk et al.   Annals of the New York Academy of Sciences

Physico-Chemical Characterization of Polylipid Nanoparticles for Gene Delivery to the Liver

(2009) Maung T. Nyunt et al.   BIOCONJUGATE CHEMISTRY

An acid-labile temperature-responsive sol–gel reversible polymer for enhanced gene delivery to the myocardium and skeletal muscle cells

(2009) Ran Namgung et al.   BIOMATERIALS

Characterization and performance of nucleic acid nanoparticles combined with protamine and gold

(2009) Robert K. DeLong et al.   BIOMATERIALS

Cationic glycolipids with cyclic and open galactose head groups for the selective targeting of genes to mouse liver

(2009) Rajesh Mukthavaram et al.   BIOMATERIALS

Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer

(2009) Weilun Ke et al.   BIOMATERIALS

Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting

(2009) Marie Morille et al.   BIOMATERIALS

Tissue-specific gene delivery via nanoparticle coating

(2009) Todd J. Harris et al.   BIOMATERIALS

Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

(2009) Patrick Midoux et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cancer-Specific Transgene Expression Mediated by Systemic Injection of Nanoparticles

(2009) E. J. Chisholm et al.   CANCER RESEARCH

Nanocarriers’ entry into the cell: relevance to drug delivery

(2009) Hervé Hillaireau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP)

(2009) James J. Ludtke et al.   DRUG DELIVERY

Non-viral vectors in cystic fibrosis gene therapy: recent developments and future prospects

(2009) IA Pringle et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Nanoparticles for human liver-specific drug and gene delivery systems:in vitroandin vivoadvances

(2009) Takeshi Kasuya et al.   Expert Opinion on Drug Delivery

Recent trends in stabilising peptides and proteins in pharmaceutical formulation – considerations in the choice of excipients

(2009) Lene Jorgensen et al.   Expert Opinion on Drug Delivery

Chemically modified cell-penetrating peptides for the delivery of nucleic acids

(2009) Maarja Mäe et al.   Expert Opinion on Drug Delivery

Differential receptor-mediated drug targeting to the diseased brain

(2009) J Rip et al.   Expert Opinion on Drug Delivery

Fatty acid–spermine conjugates as DNA carriers for nonviral in vivo gene delivery

(2009) J R Viola et al.   GENE THERAPY

Chitosan–plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies

(2009) M Jean et al.   GENE THERAPY

Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers

(2009) Chie Kojima et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Brain-Targeting Mechanisms of Lactoferrin-Modified DNA-Loaded Nanoparticles

(2009) Rongqin Huang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tailoring the surface potential of gold nanoparticles with self-assembled monolayers with mixed functional groups

(2009) Yu-Chin Lin et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Parameters affecting organization and transfection efficiency of amphiphilic copolymers/DNA carriers

(2009) Caroline Roques et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy

(2009) Taavi Lehto et al.   JOURNAL OF CONTROLLED RELEASE

Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles

(2009) Rongqin Huang et al.   JOURNAL OF GENE MEDICINE

Nonviral siRNA Delivery to the Lung: Investigation of PEG−PEI Polyplexes and Their In Vivo Performance

(2009) Olivia M. Merkel et al.   MOLECULAR PHARMACEUTICS

RGD-Conjugated Dendrimer-Modified Gold Nanorods forin VivoTumor Targeting and Photothermal Therapy†

(2009) Zhiming Li et al.   MOLECULAR PHARMACEUTICS

Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals

(2009) Arkadi Zintchenko et al.   MOLECULAR THERAPY

DNA/Amphiphilic Block Copolymer Nanospheres Promote Low-dose DNA Vaccination

(2009) Dorian McIlroy et al.   MOLECULAR THERAPY

Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

(2009) Akin Akinc et al.   MOLECULAR THERAPY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Virus entry by macropinocytosis

(2009) Jason Mercer et al.   NATURE CELL BIOLOGY

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

(2009) Brian D. Brown et al.   NATURE REVIEWS GENETICS

A synthetic snRNA m3G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids

(2009) Pedro M. D. Moreno et al.   NUCLEIC ACIDS RESEARCH

Control of the in vivo Biodistribution of Hybrid Nanoparticles with Different Poly(ethylene glycol) Coatings

(2009) Anne-Charlotte Faure et al.   Small

In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(–PEG)/siRNA complexes

(2009) Anastasia Malek et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: Structure–function relationships

(2009) Andrea Beyerle et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Selective or targeted gene/drug delivery for liver tumors: advantages and current status of local delivery

(2009) Young Il Kim et al.   Expert Review of Gastroenterology & Hepatology

Amphiphilic Block Copolymers Enhance Cellular Uptake and Nuclear Entry of Polyplex-Delivered DNA

(2008) Zhihui Yang et al.   BIOCONJUGATE CHEMISTRY

Distinct Uptake Routes of Cell-Penetrating Peptide Conjugates

(2008) Per Lundin et al.   BIOCONJUGATE CHEMISTRY

Self-Assembling Polyethylenimine Derivatives Mediate Efficient siRNA Delivery in Mammalian Cells

(2008) Gaelle Creusat et al.   CHEMBIOCHEM

Phase 1b Randomized Study of Antidote-Controlled Modulation of Factor IXa Activity in Patients With Stable Coronary Artery Disease

(2008) Mark Y. Chan et al.   CIRCULATION

Physicochemical Parameters of Non-Viral Vectors that Govern Transfection Efficiency

(2008) Benoit Barteau et al.   CURRENT GENE THERAPY

Advances in non-viral gene delivery: using multifunctional envelope-type nano-device

(2008) Hidetaka Akita et al.   Expert Opinion on Drug Delivery

Nuclear-targeted chimeric vector enhancing nonviral gene transfer into skeletal muscle of Fabry mice in vivo

(2008) Matthieu D. Lavigne et al.   FASEB JOURNAL

Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers

(2008) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy

(2008) Maarja Mäe et al.   JOURNAL OF CONTROLLED RELEASE

Galactosylated multimodular lipoplexes for specific gene transfer into primary hepatocytes

(2008) Emilie Letrou-Bonneval et al.   JOURNAL OF GENE MEDICINE

Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery

(2008) Christine I. Wooddell et al.   JOURNAL OF GENE MEDICINE

In vivotargeted gene delivery by cationic nanoparticles for treatment of hepatocellular carcinoma

(2008) Sonsoles Díez et al.   JOURNAL OF GENE MEDICINE

RNA Interference Inhibits Respiratory Syncytial Virus Replication and Disease Pathogenesis without Inhibiting Priming of the Memory Immune Response

(2008) W. Zhang et al.   JOURNAL OF VIROLOGY

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes

(2008) Lee A Davies et al.   MOLECULAR THERAPY

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

pH-triggered release of vancomycin from protein-capped porous silicon films

(2008) Loren A Perelman et al.   Nanomedicine

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression

(2008) Stephen C Hyde et al.   NATURE BIOTECHNOLOGY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

The Contributions of Paul Ehrlich to Pharmacology: A Tribute on the Occasion of the Centenary of His Nobel Prize

(2008) Fèlix Bosch et al.   PHARMACOLOGY

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

(2008) S. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA