Identifying pancreatic cancer patients for targeted treatment: the challenges and limitations of the current selection process and vision for the future

Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells

(2010) SL Showalter et al.   CANCER BIOLOGY & THERAPY

Synthetic lethal targeting ofPTENmutant cells with PARP inhibitors

(2009) Ana M. Mendes-Pereira et al.   EMBO Molecular Medicine

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Should Patients With a Strong Family History of Pancreatic Cancer Be Screened on a Periodic Basis for Cancer of the Pancreas?

(2009) William M. Steinberg et al.   PANCREAS

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

(2009) S. Jones et al.   SCIENCE

A Syngeneic Variance Library for Functional Annotation of Human Variation: Application to BRCA2

(2008) T. Hucl et al.   CANCER RESEARCH

Drug Resistance Caused by Reversion Mutation

(2008) A. Ashworth   CANCER RESEARCH

The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets

(2008) M. José García et al.   Clinical & Translational Oncology

BRCA1 and BRCA2 Mutation Prevalence and Clinical Characteristics of a Population-Based Series of Ovarian Cancer Cases from Denmark

(2008) M. Soegaard et al.   CLINICAL CANCER RESEARCH

A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair

(2008) Alan Ashworth   JOURNAL OF CLINICAL ONCOLOGY

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE

Resistance to therapy caused by intragenic deletion in BRCA2

(2008) Stacey L. Edwards et al.   NATURE

Bench to bedside: BRCA: From therapeutic target to therapeutic shield

(2008) Neil P Shah   NATURE MEDICINE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

High frequency of BRCA1/2 germline mutations in consecutive ovarian cancer patients in Poland

(2007) Izabela Brozek et al.   GYNECOLOGIC ONCOLOGY