Phenotypic alterations, clinical impact and therapeutic potential of regulatory T cells in cancer

Expression of ICOS on Human Melanoma-Infiltrating CD4+CD25highFoxp3+ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression

(2014) L. Strauss et al.   JOURNAL OF IMMUNOLOGY

Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells

(2013) Y. Zhang et al.   BLOOD

Denileukin diftitox (ONTAK) induces a tolerogenic phenotype in dendritic cells and stimulates survival of resting Treg

(2013) A. S. Baur et al.   BLOOD

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

(2013) S. Dong et al.   BLOOD

Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients

(2013) H-B Jie et al.   BRITISH JOURNAL OF CANCER

Neuropilin 1: function and therapeutic potential in cancer

(2013) Belal Chaudhary et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Regulatory T cell subsets in human cancer: are they regulating for or against tumor progression?

(2013) Theresa L. Whiteside   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes

(2013) Alessia Parodi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

(2013) J. Duraiswamy et al.   CANCER RESEARCH

Effects of Adjuvant Chemoradiotherapy on the Frequency and Function of Regulatory T Cells in Patients with Head and Neck Cancer

(2013) P. J. Schuler et al.   CLINICAL CANCER RESEARCH

Association of circulating regulatory T cell number with the incidence and prognosis of diffuse large B-cell lymphoma

(2013) Magdalena Głowala-Kosińska et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

(2013) Erin E. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Helios marks strongly autoreactive CD4+T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB

(2013) Stephen R. Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Memory Helios- FOXP3+ Regulatory T Cells (Tregs) Encompass Induced Tregs That Express Aiolos and Respond to IL-1  by Downregulating Their Suppressor Functions

(2013) C. Raffin et al.   JOURNAL OF IMMUNOLOGY

Helios+ and Helios- Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans

(2013) M. E. Himmel et al.   JOURNAL OF IMMUNOLOGY

Restoring Immune Function of Tumor-Specific CD4+ T Cells during Recurrence of Melanoma

(2013) S. R. Goding et al.   JOURNAL OF IMMUNOLOGY

Characteristics of chemokine signatures elicited by EGF and TNF in ovarian cancer cells

(2013) Deok-Soo Son et al.   Journal of Inflammation-London

Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer

(2013) Zhiqiang Guo et al.   Journal of Translational Medicine

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity

(2013) Yujie Liu et al.   NATURE MEDICINE

New checkpoint inhibitors ride the immunotherapy tsunami

(2013) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tim-3 Expression Defines Regulatory T Cells in Human Tumors

(2013) Jing Yan et al.   PLoS One

Phenotypic and functional characteristic of a newly identified CD8+Foxp3−CD103+ regulatory T cells

(2013) Ya Liu et al.   Journal of Molecular Cell Biology

Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance

(2013) C Bryant et al.   Blood Cancer Journal

The Tumor Microenvironment Contribution to Development, Growth, Invasion and Metastasis of Head and Neck Squamous Cell Carcinomas

(2013) Sittichai Koontongkaew   Journal of Cancer

Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

(2013) M. J. Selby et al.   Cancer Immunology Research

Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity

(2013) Mahesh Yadav et al.   Frontiers in Immunology

Adenosine and Prostaglandin E2 Production by Human Inducible Regulatory T Cells in Health and Disease

(2013) Theresa L. Whiteside et al.   Frontiers in Immunology

Natural and Induced T Regulatory Cells in Cancer

(2013) Dennis O. Adeegbe et al.   Frontiers in Immunology

TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

(2013) Kaori Sakuishi et al.   OncoImmunology

Expression of neuropilin-1 on in vivo induced regulatory T cells

(2013) Christopher J Nirschl et al.   Journal for ImmunoTherapy of Cancer

Regulatory T Cell Infiltration Predicts Outcome Following Resection of Colorectal Cancer Liver Metastases

(2012) Steven C. Katz et al.   ANNALS OF SURGICAL ONCOLOGY

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

(2012) T. Duhen et al.   BLOOD

Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+tumor infiltrating lymphocytes in ductal and lobular breast cancers

(2012) Raoul Droeser et al.   BMC CANCER

Peritumoral FOXP3+ regulatory T cell is sensitive to chemotherapy while intratumoral FOXP3+ regulatory T cell is prognostic predictor of breast cancer patients

(2012) Fangfang Liu et al.   BREAST CANCER RESEARCH AND TREATMENT

Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas

(2012) Muhammad Baghdadi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Role of Chemokines and Chemokine Receptors in Shaping the Effector Phase of the Antitumor Immune Response

(2012) K. Franciszkiewicz et al.   CANCER RESEARCH

Regulatory T-cell Modulation Using Cyclophosphamide in Vaccine Approaches: A Current Perspective

(2012) D. T. Le et al.   CANCER RESEARCH

IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

(2012) J. Emmerich et al.   CANCER RESEARCH

Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer

(2012) Hiroyuki Suzuki et al.   CLINICAL IMMUNOLOGY

CD26: A negative selection marker for human Treg cells

(2012) Francisco J. Salgado et al.   CYTOMETRY PART A

Tumor-Infiltrating FoxP3+ Tregs and CD8+ T Cells Affect the Prognosis of Hepatocellular Carcinoma Patients

(2012) Yong Huang et al.   DIGESTION

Phenotypic and functional characteristics of CD4+CD39+ FOXP3+ and CD4+CD39+FOXP3neg T-cell subsets in cancer patients

(2012) Patrick J. Schuler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Helios expression in FoxP3+T regulatory cells

(2012) Eyad Elkord et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

(2012) Takahisa Miyao et al.   IMMUNITY

Transient Foxp3+ regulatory T-cell depletion enhances therapeutic anticancer vaccination targeting the immune-stimulatory properties of NKT cells

(2012) Stephen R Mattarollo et al.   IMMUNOLOGY AND CELL BIOLOGY

FOXP3 expression in tumor cells and implications for cancer progression

(2012) Tiziana Triulzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Helios Induces Epigenetic Silencing of Il2 Gene Expression in Regulatory T Cells

(2012) I. Baine et al.   JOURNAL OF IMMUNOLOGY

A Converse 4-1BB and CD40 Ligand Expression Pattern Delineates Activated Regulatory T Cells (Treg) and Conventional T Cells Enabling Direct Isolation of Alloantigen-Reactive Natural Foxp3+ Treg

(2012) A. Schoenbrunn et al.   JOURNAL OF IMMUNOLOGY

Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression

(2012) Xin Gao et al.   PLoS One

A Pilot Study of IL-2Rα Blockade during Lymphopenia Depletes Regulatory T-cells and Correlates with Enhanced Immunity in Patients with Glioblastoma

(2012) John H. Sampson et al.   PLoS One

Prognostic Impact of FoxP3+ Regulatory T Cells in Relation to CD8+ T Lymphocyte Density in Human Colon Carcinomas

(2012) Harry H. Yoon et al.   PLoS One

Expression of ROR t Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

(2012) N. R. Blatner et al.   Science Translational Medicine

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

(2012) A. J. Rech et al.   Science Translational Medicine

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4+T effector cells in patients with head and neck squamous cell carcinoma

(2012) Magis Mandapathil et al.   OncoImmunology

CD8+ cytotoxic T cell and FOXP3+ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes

(2011) Fangfang Liu et al.   BREAST CANCER RESEARCH AND TREATMENT

Immunotherapy with IL-10- and IFN-γ-producing CD4 effector cells modulate “Natural” and “Inducible” CD4 TReg cell subpopulation levels: observations in four cases of patients with ovarian cancer

(2011) Mark J. Dobrzanski et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer

(2011) E. Righi et al.   CANCER RESEARCH

Tumor Infiltration by T Lymphocytes Expressing Chemokine Receptor 7 (CCR7) Is Predictive of Favorable Outcome in Patients with Advanced Colorectal Carcinoma

(2011) P. Correale et al.   CLINICAL CANCER RESEARCH

Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs

(2011) Eyad Elkord et al.   CLINICAL IMMUNOLOGY

Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms

(2011) Mikayel Mkrtichyan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Functional Plasticity of Antigen-Specific Regulatory T Cells in Context of Tumor

(2011) C. Addey et al.   JOURNAL OF IMMUNOLOGY

Intratumoral regulatory T cells alone or in combination with cytotoxic T cells predict prognosis of hepatocellular carcinoma after resection

(2011) Kang-jie Chen et al.   MEDICAL ONCOLOGY

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

(2011) Marc Beyer et al.   NATURE IMMUNOLOGY

FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells

(2011) N McInnes et al.   ONCOGENE

Helios Expression Is a Marker of T Cell Activation and Proliferation

(2011) Tatiana Akimova et al.   PLoS One

The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T Cells

(2011) S. Amarnath et al.   Science Translational Medicine

Identification of Human Regulatory T Cells in the Setting of T-Cell Activation and Anti–CTLA-4 Immunotherapy on the Basis of Expression of Latency-Associated Peptide

(2011) Jingjing Sun et al.   Cancer Discovery

Accumulation of Foxp3+ T Regulatory Cells in Draining Lymph Nodes Correlates with Disease Progression and Immune Suppression in Colorectal Cancer Patients

(2010) L. Deng et al.   CLINICAL CANCER RESEARCH

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells

(2010) Federico Simonetta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T regulatory cells in cancer: recent advances and therapeutic potential

(2010) Eyad Elkord et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Adenosine and Prostaglandin E2Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells

(2010) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites

(2010) C. Camisaschi et al.   JOURNAL OF IMMUNOLOGY

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

(2010) Derese Getnet et al.   MOLECULAR IMMUNOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Development of the Anti–CTLA-4 Antibody Tremelimumab

(2010) Antoni Ribas   SEMINARS IN ONCOLOGY

In vivo-activated CD103+ Foxp3+ Tregs: of men and mice

(2009) O. Rotzschke et al.   BLOOD

Differences in Tumor Regulatory T-Cell Localization and Activation Status Impact Patient Outcome

(2009) C. Menetrier-Caux et al.   CANCER RESEARCH

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

(2009) G. Wieczorek et al.   CANCER RESEARCH

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

(2009) M. Gobert et al.   CANCER RESEARCH

A Phase I Pharmacokinetic and Biological Correlative Study of IMP321, a Novel MHC Class II Agonist, in Patients with Advanced Renal Cell Carcinoma

(2009) C. Brignone et al.   CLINICAL CANCER RESEARCH

Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner

(2009) Xiang-Liang Yuan et al.   CLINICAL IMMUNOLOGY

Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg

(2009) Julie Stockis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

(2009) William D. Hastings et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Regulatory T Cell (Treg) Subsets Return in Patients with Refractory Lupus following Stem Cell Transplantation, and TGF- -Producing CD8+ Treg Cells Are Associated with Immunological Remission of Lupus

(2009) L. Zhang et al.   JOURNAL OF IMMUNOLOGY

In Vivo Dynamical Interactions between CD4 Tregs, CD8 Tregs and CD4+CD25− Cells in Mice

(2009) Arnon Arazi et al.   PLoS One

GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells

(2009) D. Q. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor ROR t

(2009) M. Ayyoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

(2008) M. Ahmadzadeh et al.   BLOOD

CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells

(2008) M. Kleinewietfeld et al.   BLOOD

Prognostic Value of CD25 Expression on Lymphocytes and Tumor Cells in Squamous-Cell Carcinoma of the Head and Neck

(2008) David Loose et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease

(2008) C. Bergmann et al.   CLINICAL CANCER RESEARCH

Critical role of IL-2 and TGF-β in generation, function and stabilization of Foxp3+CD4+ Treg

(2008) David A. Horwitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma

(2008) A. Tzankov et al.   HAEMATOLOGICA

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

(2008) Tomoki Ito et al.   IMMUNITY

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

(2008) Paul Salama et al.   JOURNAL OF CLINICAL ONCOLOGY

The CD4+CD26− T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile

(2008) Yue Ma et al.   LABORATORY INVESTIGATION