Adenoviral vector-mediated gene therapy for gliomas: coming of age

Plasmacytoid Dendritic Cells in the Tumor Microenvironment: Immune Targets for Glioma Therapeutics

(2015) Marianela Candolfi et al.   NEOPLASIA

Temozolomide Does Not Impair Gene Therapy-Mediated Antitumor Immunity in Syngeneic Brain Tumor Models

(2014) M. Candolfi et al.   CLINICAL CANCER RESEARCH

BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide

(2013) Luis Sanchez-Perez et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial

(2013) Manfred Westphal et al.   LANCET ONCOLOGY

Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

(2013) A. Aiuti et al.   SCIENCE

Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

(2013) A. Biffi et al.   SCIENCE

Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma

(2013) Mariana Puntel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effectiveness and Preclinical Safety Profile of Doxycycline to Be Used “Off-Label” to Induce Therapeutic Transgene Expression in a Phase I Clinical Trial for Glioma

(2013) Nathan VanderVeen et al.   Human Gene Therapy Clinical Development

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Immune-mediated Loss of Transgene Expression From Virally Transduced Brain Cells Is Irreversible, Mediated by IFNγ, Perforin, and TNFα, and due to the Elimination of Transduced Cells

(2012) Jeffrey M Zirger et al.   MOLECULAR THERAPY

Gene Therapy-Mediated Reprogramming Tumor Infiltrating T Cells Using IL-2 and Inhibiting NF-κB Signaling Improves the Efficacy of Immunotherapy in a Brain Cancer Model

(2012) Yohei Mineharu et al.   Neurotherapeutics

Engineering the Brain Tumor Microenvironment Enhances the Efficacy of Dendritic Cell Vaccination: Implications for Clinical Trial Design

(2011) Y. Mineharu et al.   CLINICAL CANCER RESEARCH

Gene Therapy of Intracranial Glioma Using Interleukin 12–Secreting Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells

(2011) Chung Heon Ryu et al.   HUMAN GENE THERAPY

Phase IB Study of Gene-Mediated Cytotoxic Immunotherapy Adjuvant to Up-Front Surgery and Intensive Timing Radiation for Malignant Glioma

(2011) E. Antonio Chiocca et al.   JOURNAL OF CLINICAL ONCOLOGY

Combined Flt3L/TK Gene Therapy Induces Immunological Surveillance Which Mediates an Immune Response Against a Surrogate Brain Tumor Neoantigen

(2011) Gwendalyn D King et al.   MOLECULAR THERAPY

Identification and Visualization of CD8+ T Cell Mediated IFN-γ Signaling in Target Cells during an Antiviral Immune Response in the Brain

(2011) Mariana Puntel et al.   PLoS One

MDA-7/IL-24 as a cancer therapeutic: from bench to bedside

(2010) Paul Dent et al.   ANTI-CANCER DRUGS

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24

(2010) Luni Emdad et al.   CANCER BIOLOGY & THERAPY

Oncolytic adenovirus based on serotype 3

(2010) O Hemminki et al.   CANCER GENE THERAPY

Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma

(2010) A K M G Muhammad et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Novel Bicistronic High-Capacity Gutless Adenovirus Vector That Drives Constitutive Expression of Herpes Simplex Virus Type 1 Thymidine Kinase and Tet-Inducible Expression of Flt3L for Glioma Therapeutics

(2010) M. Puntel et al.   JOURNAL OF VIROLOGY

Inhibition of Multiple Protective Signaling Pathways and Ad.5/3 Delivery Enhances mda-7/IL-24 Therapy of Malignant Glioma

(2010) Hossein A Hamed et al.   MOLECULAR THERAPY

Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy

(2010) Z. Khan et al.   NEURO-ONCOLOGY

Experimental approaches for the treatment of malignant gliomas

(2010) Leopold Arko et al.   PHARMACOLOGY & THERAPEUTICS

Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology

(2010) D. Larocque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics

(2010) M. Candolfi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiglioma Immunological Memory in Response to Conditional Cytotoxic/Immune-Stimulatory Gene Therapy: Humoral and Cellular Immunity Lead to Tumor Regression

(2009) A.K.M. Ghulam Muhammad et al.   CLINICAL CANCER RESEARCH

Release of HMGB1 in Response to Proapoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity

(2009) M. Candolfi et al.   CLINICAL CANCER RESEARCH

Adenovirus Mediated Herpes Simplex Virus-Thymidine Kinase/Ganciclovir Gene Therapy for Resectable Malignant Glioma

(2009) Ann-Marie Maatta et al.   CURRENT GENE THERAPY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

(2009) James F Curtin et al.   PLOS MEDICINE

Turning the gene tap off; implications of regulating gene expression for cancer therapeutics

(2008) J. F. Curtin et al.   MOLECULAR CANCER THERAPEUTICS

A Phase I Trial of Ad.hIFN-β Gene Therapy for Glioma

(2008) E Antonio Chiocca et al.   MOLECULAR THERAPY

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal Stem Cells Effectively Deliver an Oncolytic Adenovirus to Intracranial Glioma

(2008) Adam M. Sonabend et al.   STEM CELLS

Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model

(2007) Gwendalyn D. King et al.   NEURO-ONCOLOGY

Characterization of Herpes Simplex Virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity

(2002) Mark S. Kokoris et al.   PROTEIN SCIENCE