Camelid single-domain antibody-fragment engineering for (pre)clinicalin vivomolecular imaging applications: adjusting the bullet to its target

DARPin-targeting of Measles Virus: Unique Bispecificity, Effective Oncolysis, and Enhanced Safety

(2013) Katrin Friedrich et al.   MOLECULAR THERAPY

Pharmacokinetic, Biodistribution, and Biophysical Profiles of TNF Nanobodies Conjugated to Linear or Branched Poly(ethylene glycol)

(2012) Yulia Vugmeyster et al.   BIOCONJUGATE CHEMISTRY

Nanobody-Based Targeting of the Macrophage Mannose Receptor for EffectiveIn VivoImaging of Tumor-Associated Macrophages

(2012) Kiavash Movahedi et al.   CANCER RESEARCH

Nanobodies Targeting Mouse/Human VCAM1 for the Nuclear Imaging of Atherosclerotic Lesions

(2012) Alexis Broisat et al.   CIRCULATION RESEARCH

Development of177Lu-nanobodies for radioimmunotherapy of HER2-positive breast cancer: evaluation of different bifunctional chelators

(2012) Matthias D'Huyvetter et al.   Contrast Media & Molecular Imaging

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

(2012) Tengfei Li et al.   FASEB JOURNAL

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Advances in Immuno–Positron Emission Tomography: Antibodies for Molecular Imaging in Oncology

(2012) Scott M. Knowles et al.   JOURNAL OF CLINICAL ONCOLOGY

Nanobodies Targeting the Hepatocyte Growth Factor: Potential New Drugs for Molecular Cancer Therapy

(2012) M. J. W. D. Vosjan et al.   MOLECULAR CANCER THERAPEUTICS

Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody

(2012) Marek Pruszynski et al.   NUCLEAR MEDICINE AND BIOLOGY

In Vivo Detection of Amyloid-β Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease

(2012) Rob J. A. Nabuurs et al.   PLoS One

Use of64Cu-labeled Fibronectin Domain with EGFR-Overexpressing Tumor Xenograft: Molecular Imaging

(2012) Benjamin J. Hackel et al.   RADIOLOGY

ImmunoPET using engineered antibody fragments: fluorine-18 labeled diabodies for same-day imaging

(2012) Tove Olafsen et al.   TUMOR BIOLOGY

Specific Cell Targeting with Nanobody Conjugated Branched Gold Nanoparticles for Photothermal Therapy

(2011) Bieke Van de Broek et al.   ACS Nano

Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier

(2011) G Caljon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immuno-imaging using nanobodies

(2011) Ilse Vaneycken et al.   CURRENT OPINION IN BIOTECHNOLOGY

Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET

(2011) Maria J. W. D. Vosjan et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer

(2011) Ilse Vaneycken et al.   FASEB JOURNAL

Nanobody-coupled microbubbles as novel molecular tracer

(2011) Sophie Hernot et al.   JOURNAL OF CONTROLLED RELEASE

Imaging of Human Epidermal Growth Factor Receptor Type 2 Expression with 18F-Labeled Affibody Molecule ZHER2:2395 in a Mouse Model for Ovarian Cancer

(2011) S. Heskamp et al.   JOURNAL OF NUCLEAR MEDICINE

A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor

(2011) Stuart L. Emanuel et al.   mAbs

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Transmigration of beta amyloid specific heavy chain antibody fragments across the in vitro blood–brain barrier

(2011) K.S. Rutgers et al.   NEUROSCIENCE

The Future of Molecular Imaging

(2011) Albert J. Sinusas et al.   JACC-Cardiovascular Imaging

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Protein-based tumor molecular imaging probes

(2010) Xin Lin et al.   AMINO ACIDS

Peptide-Based Probes for Targeted Molecular Imaging

(2010) Seulki Lee et al.   BIOCHEMISTRY

Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies

(2010) U Iqbal et al.   BRITISH JOURNAL OF CANCER

Kinetic analysis of novel mono- and multivalent VHH-fragments and their application for molecular imaging of brain tumours

(2010) U Iqbal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size

(2010) C. Zahnd et al.   CANCER RESEARCH

Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice

(2010) Lea Olive Tchouate Gainkam et al.   Contrast Media & Molecular Imaging

Nanobodies as Tools for In Vivo Imaging of Specific Immune Cell Types

(2010) K. De Groeve et al.   JOURNAL OF NUCLEAR MEDICINE

In Vitro Analysis and In Vivo Tumor Targeting of a Humanized, Grafted Nanobody in Mice Using Pinhole SPECT/Micro-CT

(2010) I. Vaneycken et al.   JOURNAL OF NUCLEAR MEDICINE

Molecular Imaging of HER2-Expressing Malignant Tumors in Breast Cancer Patients Using Synthetic 111In- or 68Ga-Labeled Affibody Molecules

(2010) R. P. Baum et al.   JOURNAL OF NUCLEAR MEDICINE

Correlation Between Epidermal Growth Factor Receptor-Specific Nanobody Uptake and Tumor Burden: A Tool for Noninvasive Monitoring of Tumor Response to Therapy

(2010) Lea Olive Tchouate Gainkam et al.   MOLECULAR IMAGING AND BIOLOGY

A Camelid Anti-PrP Antibody Abrogates PrPSc Replication in Prion-Permissive Neuroblastoma Cell Lines

(2010) Daryl Rhys Jones et al.   PLoS One

Differential tumor-targeting abilities of three single-domain antibody formats

(2009) Andrea Bell et al.   CANCER LETTERS

Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

(2009) R. H. Kimura et al.   CANCER RESEARCH

Imaging of the unstable plaque: how far have we got?

(2009) Christian M. Matter et al.   EUROPEAN HEART JOURNAL

124I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of 131I-L19-SIP radioimmunotherapy

(2009) Bernard M. Tijink et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A review of molecular imaging studies reaching the clinical stage

(2009) Franklin C. Wong et al.   EUROPEAN JOURNAL OF RADIOLOGY

Development and Characterization of Clinical-Grade 89Zr-Trastuzumab for HER2/neu ImmunoPET Imaging

(2009) E. C.F. Dijkers et al.   JOURNAL OF NUCLEAR MEDICINE

Targeting of HER2-Expressing Tumors with a Site-Specifically 99mTc-Labeled Recombinant Affibody Molecule, ZHER2:2395, with C-Terminally Engineered Cysteine

(2009) S. Ahlgren et al.   JOURNAL OF NUCLEAR MEDICINE

68Ga-PET: a powerful generator-based alternative to cyclotron-based PET radiopharmaceuticals

(2008) Melpomeni Fani et al.   Contrast Media & Molecular Imaging

General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold

(2008) Cécile Vincke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of the Biodistribution and Tumor Targeting of Two 99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT

(2008) L. O. T. Gainkam et al.   JOURNAL OF NUCLEAR MEDICINE

Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

(2008) B. M. Tijink et al.   MOLECULAR CANCER THERAPEUTICS

SPECT Imaging with 99mTc-Labeled EGFR-Specific Nanobody for In Vivo Monitoring of EGFR Expression

(2008) Lieven Huang et al.   MOLECULAR IMAGING AND BIOLOGY

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY

Camelid immunoglobulins and nanobody technology

(2008) S. Muyldermans et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Single-domain antibody fragments with high conformational stability

(2002) Mireille Dumoulin et al.   PROTEIN SCIENCE