Immune alterations in malignant melanoma and current immunotherapy concepts

Survival and long-term follow-up of safety and response in patients (pts) with advanced melanoma (MEL) in a phase I trial of nivolumab (anti-PD-1; BMS-936558; ONO-4538).

(2017) Mario Sznol et al.   JOURNAL OF CLINICAL ONCOLOGY

Antiproliferative Activity of IL-27 on Melanoma

(2014) T. Yoshimoto et al.   JOURNAL OF IMMUNOLOGY

Adjuvant immunotherapy of melanoma and development of new approaches using the neoadjuvant approach

(2013) Diwakar Davar et al.   CLINICS IN DERMATOLOGY

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Melanoma

(2013) Adam Ingraffea   Facial Plastic Surgery Clinics of North America

Human Langerhans cells are immature in melanoma sentinel lymph nodes

(2012) G. Gerlini et al.   BLOOD

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Melanoma immunoediting by NK cells

(2012) Mirna Balsamo et al.   OncoImmunology

Up-Regulation of MUC18 in Airway Epithelial Cells by IL-13

(2011) Glenn C. Simon et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prognostic impact of B-cell density in cutaneous melanoma

(2011) Andrea Ladányi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Unique Functional Status of Natural Killer Cells in Metastatic Stage IV Melanoma Patients and Its Modulation by Chemotherapy

(2011) G. Fregni et al.   CLINICAL CANCER RESEARCH

Combination of lentivector immunization and low-dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity

(2011) Sophie R. Sierro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association between natural killer cells and regression in melanocytic lesions

(2011) Kristopher McKay et al.   HUMAN PATHOLOGY

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth

(2011) Soraya Zorro Manrique et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helper Activity of Natural Killer Cells During the Dendritic Cell-mediated Induction of Melanoma-specific Cytotoxic T Cells

(2011) Jeffrey L. Wong et al.   JOURNAL OF IMMUNOTHERAPY

IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice

(2011) Kazuyoshi Takeda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

(2011) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dendritic Cells Crosspresent Antigens from Live B16 Cells More Efficiently than from Apoptotic Cells and Protect from Melanoma in a Therapeutic Model

(2011) Diana Matheoud et al.   PLoS One

B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer

(2010) David J. DiLillo et al.   Annals of the New York Academy of Sciences

Induction of Monocyte Chemoattractant Protein-1 and Interleukin-10 by TGF 1 in Melanoma Enhances Tumor Infiltration and Immunosuppression

(2010) N. Diaz-Valdes et al.   CANCER RESEARCH

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice

(2010) D. J. DiLillo et al.   JOURNAL OF IMMUNOLOGY

Alternatively Activated Macrophage Possess Antitumor Cytotoxicity That Is Induced by IL-4 and Mediated by Arginase-1

(2010) Julia I. Ellyard et al.   JOURNAL OF IMMUNOTHERAPY

Control of Established Melanoma by CD27 Stimulation Is Associated With Enhanced Effector Function and Persistence, and Reduced PD-1 Expression of Tumor Infiltrating CD8+ T Cells

(2010) Drew J. Roberts et al.   JOURNAL OF IMMUNOTHERAPY

Enhanced Tumor Eradication by Combining CTLA-4 or PD-1 Blockade With CpG Therapy

(2010) Sara M. Mangsbo et al.   JOURNAL OF IMMUNOTHERAPY

In-vitro IL-2 or IFN-α-induced NKG2D and CD161 NK cell receptor expression indicates novel aspects of NK cell activation in metastatic melanoma patients

(2010) Gordana Konjević et al.   MELANOMA RESEARCH

Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis

(2010) Aaron S Mansfield et al.   MODERN PATHOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

CTLA-4 blockade: therapeutic potential in cancer treatments

(2010) Ahmad Tarhini   OncoTargets and Therapy

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

(2009) M. Ahmadzadeh et al.   BLOOD

Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

(2009) Celestia S. Higano et al.   CANCER

Systemic dysregulation of CEACAM1 in melanoma patients

(2009) Gal Markel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Expression of adhesion molecules and ligands for activating and costimulatory receptors involved in cell-mediated cytotoxicity in a large panel of human melanoma cell lines

(2009) Javier G. Casado et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Collapse of the CD27+ B-Cell Compartment Associated with Systemic Plasmacytosis in Patients with Advanced Melanoma and Other Cancers

(2009) E. L. Carpenter et al.   CLINICAL CANCER RESEARCH

Anti-Programmed Death-1 Synergizes with Granulocyte Macrophage Colony-Stimulating Factor-Secreting Tumor Cell Immunotherapy Providing Therapeutic Benefit to Mice with Established Tumors

(2009) B. Li et al.   CLINICAL CANCER RESEARCH

Natural killer cells kill human melanoma cells with characteristics of cancer stem cells

(2009) G. Pietra et al.   INTERNATIONAL IMMUNOLOGY

Inflaming metastasis

(2009) Alberto Mantovani   NATURE

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

(2009) M. Balsamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired interferon signaling is a common immune defect in human cancer

(2009) R. J. Critchley-Thorne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Situ Regulation of DC Subsets and T Cells Mediates Tumor Regression in Mice

(2009) O. A. Ali et al.   Science Translational Medicine

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

(2008) M. Ahmadzadeh et al.   BLOOD

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Type 2 Bias of T Cells Expanded from the Blood of Melanoma Patients Switched to Type 1 by IL-12p70 mRNA-Transfected Dendritic Cells

(2008) K. Minkis et al.   CANCER RESEARCH

A Subset of Host B Lymphocytes Controls Melanoma Metastasis through a Melanoma Cell Adhesion Molecule/MUC18-Dependent Interaction: Evidence from Mice and Humans

(2008) F. I. Staquicini et al.   CANCER RESEARCH

Transforming Growth Factor-  Suppresses the Ability of Ski to Inhibit Tumor Metastasis by Inducing Its Degradation

(2008) E. Le Scolan et al.   CANCER RESEARCH

Melanoma and Immunosuppression

(2008) Anna Belloni-Fortina et al.   DERMATOLOGY

Cancer Immunotherapy by Dendritic Cells

(2008) Cornelis J.M. Melief   IMMUNITY

Notch1 is an effector of Akt and hypoxia in melanoma development

(2008) Barbara Bedogni et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Transforming growth factor-β in cutaneous melanoma

(2008) Delphine Javelaud et al.   Pigment Cell & Melanoma Research