Preclinical models of multiple myeloma: a critical appraisal

Increased Regulatory versus Effector T Cell Development Is Associated with Thymus Atrophy in Mouse Models of Multiple Myeloma

(2014) A. Laronne-Bar-On et al.   JOURNAL OF IMMUNOLOGY

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

(2013) Anthony Rongvaux et al.   Annual Review of Immunology

Potentin vitroandin vivoactivity of sorafenib in multiple myeloma: induction of cell death, CD138-downregulation and inhibition of migration through actin depolymerization

(2013) Josefina Udi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

(2012) R. W. J. Groen et al.   BLOOD

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

(2012) M. Chesi et al.   BLOOD

Synthetic miR-34a Mimics as a Novel Therapeutic Agent for Multiple Myeloma: In Vitro and In Vivo Evidence

(2012) M. T. Di Martino et al.   CLINICAL CANCER RESEARCH

Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model

(2012) B. E. Swift et al.   HAEMATOLOGICA

Highly activated and expanded natural killer cells for multiple myeloma immunotherapy

(2012) T. K. Garg et al.   HAEMATOLOGICA

Therapeutic effects of intrabone and systemic mesenchymal stem cell cytotherapy on myeloma bone disease and tumor growth

(2012) Xin Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

2011 in reflection

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Optical Imaging of Disseminated Leukemia Models in Mice with Near-Infrared Probe Conjugated to a Monoclonal Antibody

(2012) Sabrina Pesnel et al.   PLoS One

FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model

(2012) Ulrich Deuschle et al.   PLoS One

A germline-competent embryonic stem cell line from NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice

(2012) Carlisle P. Landel et al.   TRANSGENIC RESEARCH

Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications

(2011) J. Jakubikova et al.   BLOOD

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

(2011) Y. X. Zhu et al.   BLOOD

Diversity of Human Leukemia Xenograft Mouse Models: Implications for Disease Biology

(2011) L. H. Meyer et al.   CANCER RESEARCH

A Blueprint for Advancing Genetics-Based Cancer Therapy

(2011) William R. Sellers   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Emerging Therapies Targeting Tumor Vasculature in Multiple Myeloma and other Hematologic and Solid Malignancies

(2011) K. Podar et al.   CURRENT CANCER DRUG TARGETS

Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model

(2011) Claudia Wehr et al.   INTERNATIONAL JOURNAL OF CANCER

Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

(2011) Marina Y. Konopleva et al.   JOURNAL OF CLINICAL ONCOLOGY

A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells

(2011) T Calimeri et al.   LEUKEMIA

Challenging the current approaches to multiple myeloma- and other cancer-related bone diseases: from bisphosphonates to targeted therapy

(2011) Martina Kleber et al.   LEUKEMIA & LYMPHOMA

Early and mature endothelial progenitors and VEGFR2+-cells in multiple myeloma: Association with disease characteristics and variation in different cell compartments

(2011) Josefina Udi et al.   LEUKEMIA RESEARCH

Animal models: Towards a myeloma mouse

(2011) Sarah DeWeerdt   NATURE

Sensitive Dual Color In Vivo Bioluminescence Imaging Using a New Red Codon Optimized Firefly Luciferase and a Green Click Beetle Luciferase

(2011) Laura Mezzanotte et al.   PLoS One

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

(2011) F. Notta et al.   SCIENCE

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Growth and differentiation of bone marrow stromal cells on biodegradable polymer scaffolds: An in vitro study

(2010) Ying Xue et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Of Mice and Humans: Are They the Same?--Implications in Cancer Translational Research

(2010) M. de Jong et al.   JOURNAL OF NUCLEAR MEDICINE

Osteoblastogenesis and tumor growth in myeloma

(2010) Shmuel Yaccoby   LEUKEMIA & LYMPHOMA

European Myeloma Network: the 3rd Trialist Forum Consensus Statement from the European experts meeting on multiple myeloma

(2010) Monika Engelhardt et al.   LEUKEMIA & LYMPHOMA

Telomerase Inhibition Targets Clonogenic Multiple Myeloma Cells through Telomere Length-Dependent and Independent Mechanisms

(2010) Sarah K. Brennan et al.   PLoS One

Humanized nonobese diabetic-scid IL2r null mice are susceptible to lethal Salmonella Typhi infection

(2010) S. J. Libby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Placenta-Derived Adherent Cells Prevent Bone loss, Stimulate Bone formation, and Suppress Growth of Multiple Myeloma in Bone

(2010) Xin Li et al.   STEM CELLS

The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth

(2009) A. Pennisi et al.   BLOOD

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy

(2009) A. K. Azab et al.   BLOOD

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

(2009) M. Fulciniti et al.   BLOOD

The leukemic stem cell niche: current concepts and therapeutic opportunities

(2009) S. W. Lane et al.   BLOOD

 1 Integrin Adhesion Enhances IL-6-Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation

(2009) K. H. Shain et al.   CANCER RESEARCH

A High-Affinity Fully Human Anti-IL-6 mAb, 1339, for the Treatment of Multiple Myeloma

(2009) M. Fulciniti et al.   CLINICAL CANCER RESEARCH

A comparison of cytokine production in 2-dimensional and 3-dimensional cultures of bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells.

(2009) Barbara Zdzisińska et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Targeted Disruption of the CXCL12/CXCR4 Axis Inhibits Osteolysis in a Murine Model of Myeloma-Associated Bone Loss

(2009) Peter Diamond et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma

(2008) J. Kirshner et al.   BLOOD

Role of decorin in the antimyeloma effects of osteoblasts

(2008) X. Li et al.   BLOOD

Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth

(2008) Y.-W. Qiang et al.   BLOOD

AID-Dependent Activation of a MYC Transgene Induces Multiple Myeloma in a Conditional Mouse Model of Post-Germinal Center Malignancies

(2008) Marta Chesi et al.   CANCER CELL

An Update on the Xenograft and Mouse Models Suitable for Investigating New Therapeutic Compounds for the Treatment of B-Cell Malignancies

(2008) Paolo Macor et al.   CURRENT PHARMACEUTICAL DESIGN

The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells and unwitting host to molecular parasites

(2008) Y Shiozawa et al.   LEUKEMIA

Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma

(2008) R A Kyle et al.   LEUKEMIA