Review
Immunology
Jaehwan Kim, Ariana Moreno, James G. G. Krueger
Summary: Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults in the US, with immunopathogenesis paradigms rapidly evolving due to advancements in technology. Single-cell RNA sequencing technology is now being applied to clinical trials of biologics to test the expansion of regulatory immune cell subsets involved in skin homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Christopher Tay, Atsushi Tanaka, Shimon Sakaguchi
Summary: Regulatory T cells (Tregs) in tumor tissues can be selectively targeted to enhance anti-tumor immune responses, while maintaining immune homeostasis in healthy organs. Current strategies such as immune checkpoint blockade (ICB) antibodies and differential targeting of surface and intracellular molecules show promise in this regard. Combining Treg targeting with ICB antibodies may enhance the efficacy of cancer immunotherapy.
Article
Multidisciplinary Sciences
Noriko Sato, Richard N. Bamford, Bonita R. Bryant, Yutaka Tagaya, Thomas A. Waldmann
Summary: When purified, naive T cells and regulatory T cells could not proliferate to the γC-cytokines IL-2, IL-7, or IL-15, despite expressing the cognate cytokine receptors. However, dendritic cells enabled their proliferation through cell-to-cell contact, independent of T cell receptor stimulation. This preconditioning effect activated specific cellular pathways and facilitated cytokine-mediated proliferation of T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Ming-Fang Wu, Yen-Hsiang Huang, Ling-Yen Chiu, Shur-Hueih Cherng, Gwo-Tarng Sheu, Tsung-Ying Yang
Summary: Curcumin induces apoptosis in chemoresistant lung cancer cells through generation of ROS, and p38 MAPK is identified as a crucial signaling pathway for this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sofya Marchenko, Iris Piwonski, Inga Hoffmann, Bruno Valentin Sinn, Catarina Alisa Kunze, Nanna Monje, Jonathan Pohl, Hagen Kulbe, Wolfgang Daniel Schmitt, Sylvia Darb-Esfahani, Elena Ioana Braicu, Ann-Christin von Bruenneck, Jalid Sehouli, Carsten Denkert, David Horst, Korinna Joehrens, Eliane Tabea Taube
Summary: The study found that higher proportions of regulatory T cells (Tregs) and lower ratios of T helper 17 cells (Th17 cells) were associated with better overall survival in high-grade serous tubo-ovarian carcinoma. This research is important for understanding the impact of the tumor microenvironment on tumor development.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Marisa K. Kilgour, Sarah MacPherson, Lauren G. Zacharias, Abigail E. Ellis, Ryan D. Sheldon, Elaine Y. Liu, Sarah Keyes, Brenna Pauly, Gillian Carleton, Bertrand Allard, Julian Smazynski, Kelsey S. Williams, Peter H. Watson, John Stagg, Brad H. Nelson, Ralph J. DeBerardinis, Russell G. Jones, Phineas T. Hamilton, Julian J. Lum
Summary: Immune regulatory metabolites in the tumor microenvironment, such as 1-methylnicotinamide (MNA), play a key role in modulating T cell responses. Despite the elevated levels of MNA in T cells infiltrating tumors, the enzyme catalyzing MNA transfer is restricted to fibroblasts and tumor cells. Functionally, MNA induces T cells to secrete tumor-promoting cytokines, suggesting it as a potential immunotherapy target for human cancer treatment.
Review
Oncology
Feng Shan, Ashwin Somasundaram, Tullia C. Bruno, Creg J. Workman, Dario A. A. Vignali
Summary: The success of immunotherapy in oncology highlights the important role of the immune system in cancer development. Regulatory T cells (Tregs) play multiple roles in the tumor microenvironment, particularly in suppressing T cell activation. Understanding the subpopulations of Tregs and their functions within the complex networks of the tumor microenvironment is crucial for the development of next-generation immunotherapies.
Article
Plant Sciences
Ah-Won Kwak, Jin Woo Park, Seung-On Lee, Jin-Young Lee, Ji-hye Seo, Goo Yoon, Mee-Hyun Lee, Joon-Seok Choi, Jung-Hyun Shim
Summary: This study found that Isolinderalactone (ILL) can exert its anticancer effect in colorectal cancer (CRC) cells sensitive and resistant to oxaliplatin (Ox) by inducing ROS-mediated apoptosis through JNK/p38 MAPK signaling pathways. This provides a new insight into therapeutic strategies targeting drug-resistant CRC.
Article
Biochemistry & Molecular Biology
Lili Sun, Chen Yao, Xiaojiao Li, Yuxing Wang, Ru Wang, Molin Wang, Qiao Liu, Denise J. Montell, Changshun Shao, Yaoqin Gong, Gongping Sun
Summary: This study reveals that cells can survive executioner caspase activation through a process called anastasis, and these surviving cells have enhanced migration and pro-angiogenic capacity. The activation of p38 MAPK plays a crucial role in anastasis and is essential for the elevated migratory and angiogenic capacity in these cells.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Guoshuai Feng, Geetika Bajpai, Pan Ma, Andrew Koenig, Andrea Bredemeyer, Inessa Lokshina, Lulu Lai, Irmgard Foerster, Florian Leuschner, Daniel Kreisel, Kory J. Lavine
Summary: This study identified CCL17 as a proinflammatory mediator in CCR2(+) macrophages and dendritic cells, and suggested that inhibiting CCL17 could promote Treg recruitment and suppress myocardial inflammation.
Review
Immunology
Sara Ness, Shiming Lin, John R. Gordon
Summary: Dendritic cells are antigen-presenting cells that interact with T cells to regulate adaptive immune responses. Under certain conditions, dendritic cells can develop into anti-inflammatory cells, inducing immunologic tolerance. Studies have shown that regulatory dendritic cells induce T cell tolerance by suppressing effector T cells and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seongchun Min, Ji Yeon Kim, Hyo Min Cho, Sujin Park, Ji Min Hwang, Hyejin You, Young Chan Chae, Won-Jae Lee, Woong Sun, Dongmin Kang, Sanghyuk Lee, Sang Won Kang
Summary: This study reveals a novel signaling pathway in which mitochondria communicate with the cytosol via the release of heat shock protein 60, leading to the activation of survival genes in the nucleus.
Article
Biochemistry & Molecular Biology
Tamara Saksida, Bojan Jevtic, Neda Djedovic, Dorde Miljkovic, Ivana Stojanovic
Summary: Autoimmune diseases are on the rise in western societies, with increasing focus on the role of reactive oxygen species (ROS) in immune response modulation. Recent studies highlight the importance of ROS in the function of dendritic cells (DC) and T cells. However, the effectiveness of ROS modulation in directing T cells and DCs towards a tolerogenic phenotype remains unclear. The potential use of ROS modulation to enhance the regulatory properties of DC and Treg in cell-based immunotherapy also requires further clarification for future therapeutic applications.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Immunology
Florianne M. J. Hafkamp, Esther W. M. Taanman-Kueter, Toni M. M. van Capel, Tom Groot Kormelink, Esther C. de Jong
Summary: This study investigated the effects of Vitamin D3 on the differentiation of specific human T cells. The results showed that Vitamin D3 can restrict the development of Th17 cells, promote the development of regulatory T cells, and reduce the production of specific cytokines by dendritic cells. This provides potential for the use of Vitamin D3 as an adjuvant in the treatment of autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Michael L. Dixon, Jonathan D. Leavenworth, Jianmei W. Leavenworth
Summary: Regulatory T-cells, particularly effector Tregs (eTregs), play a crucial role in maintaining self-tolerance and tissue homeostasis, with potential implications in tumor development. Understanding the mechanisms that modulate the stability and suppressive function of tumoral Tregs, such as eTregs and T-FR cells, can lead to the development of more effective cancer immunotherapies that target the tumor microenvironment while minimizing systemic side effects.
FRONTIERS IN IMMUNOLOGY
(2021)
