Enhanced T cell receptor gene therapy for cancer

An Inducible Caspase 9 Safety Switch Can Halt Cell Therapy-Induced Autoimmune Disease

(2014) Moniek A. de Witte et al.   JOURNAL OF IMMUNOLOGY

   T Cell Receptor Transfer to    T Cells Generates Functional Effector Cells without Mixed TCR Dimers In Vivo

(2014) L. T. van der Veken et al.   JOURNAL OF IMMUNOLOGY

Requirements for Effective Antitumor Responses of TCR Transduced T Cells

(2014) M. A. de Witte et al.   JOURNAL OF IMMUNOLOGY

Human TCR That Incorporate CD3  Induce Highly Preferred Pairing between TCR  and   Chains following Gene Transfer

(2014) Z. Sebestyen et al.   JOURNAL OF IMMUNOLOGY

Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions

(2014) Paul F. Robbins et al.   JOURNAL OF IMMUNOLOGY

Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity

(2009) S. Wilde et al.   BLOOD

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy

(2009) B. Cassani et al.   BLOOD

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

(2009) T. VandenDriessche et al.   BLOOD

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008

(2009) Wolfgang Uckert et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Kinetic Preservation of Dual Specificity of Coprogrammed Minor Histocompatibility Antigen-Reactive Virus-Specific T Cells

(2009) M. M. van Loenen et al.   CANCER RESEARCH

Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogenous TCR

(2009) S. Okamoto et al.   CANCER RESEARCH

Preclinical development of T cell receptor gene therapy

(2009) Gavin M Bendle et al.   CURRENT OPINION IN IMMUNOLOGY

Antigen choice in adoptive T-cell therapy of cancer

(2009) Rienk Offringa   CURRENT OPINION IN IMMUNOLOGY

Progress and prospects: gene therapy for inherited immunodeficiencies

(2009) W Qasim et al.   GENE THERAPY

Rapid αβ TCR-mediated responses in γδ T cells transduced with cancer-specific TCR genes

(2009) A Hiasa et al.   GENE THERAPY

Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity

(2009) P D Peng et al.   GENE THERAPY

Pseudotyping lentiviral vectors with the wild-type measles virus glycoproteins improves titer and selectivity

(2009) S Funke et al.   GENE THERAPY

Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

(2009) M. Griffioen et al.   HAEMATOLOGICA

Lentiviral Vector Design for Optimal T Cell Receptor Gene Expression in the Transduction of Peripheral Blood Lymphocytes and Tumor-Infiltrating Lymphocytes

(2009) Stephanie Jones et al.   HUMAN GENE THERAPY

Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY-ESO-1 have potent anti-tumor activity

(2009) Holger Krönig et al.   INTERNATIONAL JOURNAL OF CANCER

Increasing functional avidity of TCR-redirected T cells by removing definedN-glycosylation sites in the TCR constant domain

(2009) Jürgen Kuball et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes

(2008) S. Kaneko et al.   BLOOD

Resistance of mature T cells to oncogene transformation

(2008) S. Newrzela et al.   BLOOD

Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins

(2008) C. Frecha et al.   BLOOD

Lentiviral vectors encoding human MUC1-specific, MHC-unrestricted single-chain TCR and a fusion suicide gene: potential for universal and safe cancer immunotherapy

(2008) Xiaochuan Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Balancing between Antitumor Efficacy and Autoimmune Pathology in T-Cell-Mediated Targeting of Carcinoembryonic Antigen

(2008) R. Bos et al.   CANCER RESEARCH

Redirecting Specificity of T-Cell Populations For CD19 Using the Sleeping Beauty System

(2008) H. Singh et al.   CANCER RESEARCH

Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells

(2008) M. R. Parkhurst et al.   CLINICAL CANCER RESEARCH

Retroviral transfer of a dominant TCR prevents surface expression of a large proportion of the endogenous TCR repertoire in human T cells

(2008) D P Hart et al.   GENE THERAPY

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

(2008) J A Westwood et al.   GENE THERAPY

Peripheral CD8+ T Cell Tolerance to Self-Proteins Is Regulated Proximally at the T Cell Receptor

(2008) Ryan M. Teague et al.   IMMUNITY

Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice

(2008) Juliana Hamzah et al.   JOURNAL OF CLINICAL INVESTIGATION

Engineering higher affinity T cell receptors using a T cell display system

(2008) Adam S. Chervin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette

(2008) Matthias Leisegang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeted Cell Entry of Lentiviral Vectors

(2008) Sabrina Funke et al.   MOLECULAR THERAPY

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer

(2008) E. Kieback et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC

(2008) Jaafar N. Haidar et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS