T cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studies

An Inducible Caspase 9 Safety Switch Can Halt Cell Therapy-Induced Autoimmune Disease

(2014) Moniek A. de Witte et al.   JOURNAL OF IMMUNOLOGY

   T Cell Receptor Transfer to    T Cells Generates Functional Effector Cells without Mixed TCR Dimers In Vivo

(2014) L. T. van der Veken et al.   JOURNAL OF IMMUNOLOGY

TCR Gene Therapy of Spontaneous Prostate Carcinoma Requires In Vivo T Cell Activation

(2014) M. A. de Witte et al.   JOURNAL OF IMMUNOLOGY

Human TCR That Incorporate CD3  Induce Highly Preferred Pairing between TCR  and   Chains following Gene Transfer

(2014) Z. Sebestyen et al.   JOURNAL OF IMMUNOLOGY

Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions

(2014) Paul F. Robbins et al.   JOURNAL OF IMMUNOLOGY

Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques

(2009) S. Beq et al.   BLOOD

Safety and immunologic effects of IL-15 administration in nonhuman primates

(2009) C. Berger et al.   BLOOD

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts

(2009) Y. Cui et al.   BLOOD

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

(2009) M. D. Sharma et al.   BLOOD

Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanoma

(2009) Eduardo Huarte et al.   CANCER LETTERS

Complete Regression of Advanced Primary and Metastatic Mouse Melanomas following Combination Chemoimmunotherapy

(2009) J. Kohlmeyer et al.   CANCER RESEARCH

Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

(2009) Feng Qian et al.   CANCER RESEARCH

Antigen choice in adoptive T-cell therapy of cancer

(2009) Rienk Offringa   CURRENT OPINION IN IMMUNOLOGY

Adoptive cell therapy for the treatment of patients with metastatic melanoma

(2009) Steven A Rosenberg et al.   CURRENT OPINION IN IMMUNOLOGY

The promise and potential pitfalls of chimeric antigen receptors

(2009) Michel Sadelain et al.   CURRENT OPINION IN IMMUNOLOGY

Lentiviral Vector Design for Optimal T Cell Receptor Gene Expression in the Transduction of Peripheral Blood Lymphocytes and Tumor-Infiltrating Lymphocytes

(2009) Stephanie Jones et al.   HUMAN GENE THERAPY

Increasing functional avidity of TCR-redirected T cells by removing definedN-glycosylation sites in the TCR constant domain

(2009) Jürgen Kuball et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impact of a Recombinant Fowlpox Vaccine on the Efficacy of Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes in a Patient With Metastatic Melanoma

(2009) Franz O. Smith et al.   JOURNAL OF IMMUNOTHERAPY

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

(2009) C. Carpenito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

(2008) B. G. Till et al.   BLOOD

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes

(2008) S. Kaneko et al.   BLOOD

Resistance of mature T cells to oncogene transformation

(2008) S. Newrzela et al.   BLOOD

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

(2008) C. S. Hinrichs et al.   BLOOD

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Balancing between Antitumor Efficacy and Autoimmune Pathology in T-Cell-Mediated Targeting of Carcinoembryonic Antigen

(2008) R. Bos et al.   CANCER RESEARCH

The Melanoma-Associated Antigen A3 Mediates Fibronectin-Controlled Cancer Progression and Metastasis

(2008) W. Liu et al.   CANCER RESEARCH

Interleukin-15/Interleukin-15R  Complexes Promote Destruction of Established Tumors by Reviving Tumor-Resident CD8+ T Cells

(2008) M. Epardaud et al.   CANCER RESEARCH

Selection of human antibody fragments directed against tumor T-cell epitopes for adoptive T-cell therapy

(2008) Ralph Willemsen et al.   CYTOMETRY PART A

Cancer testis antigens in human melanoma stem cells: Expression, distribution, and methylation status

(2008) Luca Sigalotti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

(2008) Carolina Berger et al.   JOURNAL OF CLINICAL INVESTIGATION

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

(2008) Mark E. Dudley et al.   JOURNAL OF CLINICAL ONCOLOGY

Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette

(2008) Matthias Leisegang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

(2008) Angel Varela-Rohena et al.   NATURE MEDICINE

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

(2008) Martin A Pule et al.   NATURE MEDICINE

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

(2008) D. C. Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer

(2008) E. Kieback et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

About human tumor antigens to be used in immunotherapy

(2008) S. Lucas et al.   SEMINARS IN IMMUNOLOGY