Modulation of toll-like receptor function has therapeutic potential in autoimmune disease

Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures

(2014) S. M. Sacre et al.   JOURNAL OF IMMUNOLOGY

TBK1-targeted suppression of TRIF-dependent signaling pathway of toll-like receptor 3 by auranofin

(2010) Se-Jeong Park et al.   ARCHIVES OF PHARMACAL RESEARCH

Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors

(2010) Sandra Sacre et al.   ARTHRITIS AND RHEUMATISM

Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

(2010) A. Komatsuda et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Effects of age, gender, and immunosuppressive agents on in vivo toll-like receptor pathway responses

(2010) Niamat Khan et al.   HUMAN IMMUNOLOGY

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

(2010) Rita M. Tavares et al.   IMMUNITY

Oral Administration of High Molecular Weight Hyaluronan (900 kDa) Controls Immune System via Toll-like Receptor 4 in the Intestinal Epithelium

(2010) Akira Asari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Microtubule Regulator Stathmin Is an Endogenous Protein Agonist for TLR3

(2010) M. Bsibsi et al.   JOURNAL OF IMMUNOLOGY

TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus

(2010) Kevin M. Nickerson et al.   JOURNAL OF IMMUNOLOGY

Zingiber officinale Protects HaCaT cells and C57BL/6 Mice from Ultraviolet B-Induced Inflammation

(2010) Gui-Hee Guahk et al.   JOURNAL OF MEDICINAL FOOD

Multiplex Screening of 22 Single-Nucleotide Polymorphisms in 7 Toll-like Receptors: An Association Study in Rheumatoid Arthritis

(2010) C. ENEVOLD et al.   JOURNAL OF RHEUMATOLOGY

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Hydroxychloroquine in SLE: old drug, new perspectives

(2010) Thomas Dörner   Nature Reviews Rheumatology

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

(2010) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus

(2010) Ou Jin et al.   ARTHRITIS RESEARCH & THERAPY

Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats

(2010) Liesu Meng et al.   ARTHRITIS RESEARCH & THERAPY

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis

(2009) Ryan Ungaro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Toll-like Receptors in Multiple Sclerosis Mouse Experimental Models

(2009) Monica Marta   Annals of the New York Academy of Sciences

TBK1-Targeted Suppression of TRIF-Dependent Signaling Pathway of Toll-Like Receptors by 6-Shogaol, an Active Component of Ginger

(2009) Se-Jeong PARK et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

CD14-independent responses induced by a synthetic lipid A mimetic

(2009) Amandine Legat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of new SLE-associated genes with a two-step Bayesian study design

(2009) D L Armstrong et al.   GENES AND IMMUNITY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Clustering and commonalities among autoimmune diseases

(2009) Ian R. Mackay   JOURNAL OF AUTOIMMUNITY

Effects of tobacco smoke on immunity, inflammation and autoimmunity

(2009) Yoav Arnson et al.   JOURNAL OF AUTOIMMUNITY

Critical Role of TLR2 and TLR4 in Autoantibody Production and Glomerulonephritis in lpr Mutation-Induced Mouse Lupus

(2009) A. Lartigue et al.   JOURNAL OF IMMUNOLOGY

Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders

(2009) David M. Goldstein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response

(2009) ED Papadimitraki et al.   LUPUS

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

(2009) T. Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

(2009) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis

(2008) Emina Savarese et al.   ARTHRITIS AND RHEUMATISM

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis

(2008) Monica Marta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

(2008) Luke A.J. O'Neill   IMMUNITY

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

Sequence independent interferon-α induction by multimerized phosphodiester DNA depends on spatial regulation of Toll-like receptor-9 activation in plasmacytoid dendritic cells

(2008) Tobias Haas et al.   IMMUNOLOGY

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

(2008) John Castiblanco et al.   INFECTION GENETICS AND EVOLUTION

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

(2008) Beichu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Pretreatment with Toll‐like Receptor Agonists in a Mouse Model of Herpes Simplex Virus Type 1 Encephalitis

(2008) Nicolas Boivin et al.   JOURNAL OF INFECTIOUS DISEASES

Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis

(2008) Åsa Andersson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus

(2008) M Akahoshi et al.   LUPUS

Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys – a preliminary pilot study

(2008) H Ciferska et al.   LUPUS

Single-Stranded Oligonucleotides Can Inhibit Cytokine Production Induced by Human Toll-Like Receptor 3

(2008) C. T. Ranjith-Kumar et al.   MOLECULAR AND CELLULAR BIOLOGY

Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis

(2008) SA Broadley et al.   Multiple Sclerosis Journal

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

(2008) Stacy L Musone et al.   NATURE GENETICS

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE