Overcoming obstacles to develop effective and safe siRNA therapeutics

Systemic siRNA delivery to leukocyte-implicated diseases

(2011) Dan Peer et al.   CELL CYCLE

MicroRNA-like off-target transcript regulation by siRNAs is species specific

(2009) J. Burchard et al.   RNA

Tumor Regression in Mice by Delivery of Bcl-2 Small Interfering RNA with Pegylated Cationic Liposomes

(2008) Satoru Sonoke et al.   CANCER RESEARCH

Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression

(2008) M. Aleku et al.   CANCER RESEARCH

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

(2008) Priti Kumar et al.   CELL

Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation

(2008) Marjorie Robbins et al.   HUMAN GENE THERAPY

Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice

(2008) Tricia N. Lively et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids

(2008) Walt F. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA

(2008) Shyh-Dar Li et al.   MOLECULAR THERAPY

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

(2008) Kazutaka Nishina et al.   MOLECULAR THERAPY

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

(2008) Kenneth A Howard et al.   MOLECULAR THERAPY

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

(2008) Yanli Wang et al.   NATURE

Structure of the guide-strand-containing argonaute silencing complex

(2008) Yanli Wang et al.   NATURE

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Asymmetric RNA duplexes mediate RNA interference in mammalian cells

(2008) Xiangao Sun et al.   NATURE BIOTECHNOLOGY

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE

Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles

(2007) Shyh-Dar Li et al.   JOURNAL OF CONTROLLED RELEASE