Developing intrabodies for the therapeutic suppression of neurodegenerative pathology

How do you treat motor complications in Parkinson's disease: Medicine, surgery, or both?

(2010) Stanley Fahn   ANNALS OF NEUROLOGY

Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions

(2009) Elisa Greggio et al.   ASN Neuro

Mouse models of Huntington's disease and methodological considerations for therapeutic trials

(2009) Robert J. Ferrante   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prevention of oculopharyngeal muscular dystrophy by muscular expression of Llama single-chain intrabodies in vivo

(2009) Aymeric Chartier et al.   HUMAN MOLECULAR GENETICS

Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein

(2009) Sharareh Emadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct in Vivo Intracellular Selection of Conformation-sensitive Antibody Domains Targeting Alzheimer's Amyloid-β Oligomers

(2009) Giovanni Meli et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity

(2009) Erik Kvam et al.   PLoS One

Huntingtin as an essential integrator of intracellular vesicular trafficking

(2009) Juliane P. Caviston et al.   TRENDS IN CELL BIOLOGY

Huntington's disease: from pathology and genetics to potential therapies

(2008) Sara Imarisio et al.   BIOCHEMICAL JOURNAL

Development of antibody fragments for immunotherapy of prion diseases

(2008) Vincenza Campana et al.   BIOCHEMICAL JOURNAL

Intrabody and Parkinson's disease

(2008) Chun Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Combinational approach of intrabody with enhanced Hsp70 expression addresses multiple pathologies in a fly model of Huntington’s disease

(2008) J. A. McLear et al.   FASEB JOURNAL

Emerging pathways in genetic Parkinson’s disease: tangles, Lewy bodies and LRRK2

(2008) Michael J. Devine et al.   FEBS Journal

Emerging pathways in genetic Parkinson’s disease

(2008) Patrick A. Lewis   FEBS Journal

Single-chain intracellular antibodies inhibit influenza virus replication by disrupting interaction of proteins involved in viral replication and transcription

(2008) Muhammad Mahmood Mukhtar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein misfolding inside cells: The case of huntingtin and Huntington's disease

(2008) Danny M. Hatters   IUBMB LIFE

Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin

(2008) Chuan-En Wang et al.   JOURNAL OF CELL BIOLOGY

Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy

(2008) C. Zuber et al.   JOURNAL OF GENERAL VIROLOGY

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

(2008) Andleeb Zameer et al.   JOURNAL OF MOLECULAR BIOLOGY

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity

(2008) A. L. Southwell et al.   JOURNAL OF NEUROSCIENCE

Characterizing Antibody Specificity to Different Protein Morphologies by AFM

(2008) Min S. Wang et al.   LANGMUIR

CNS Delivery of Vectored Prion-specific Single-chain Antibodies Delays Disease Onset

(2008) Charles A Wuertzer et al.   MOLECULAR THERAPY

The potential of intracellular antibodies for therapeutic targeting of protein-misfolding diseases

(2008) Alessio Cardinale et al.   TRENDS IN MOLECULAR MEDICINE

Camelid immunoglobulins and nanobody technology

(2008) S. Muyldermans et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

An scFv Intrabody against the Nonamyloid Component of α-Synuclein Reduces Intracellular Aggregation and Toxicity

(2007) Sandra M. Lynch et al.   JOURNAL OF MOLECULAR BIOLOGY

Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease

(2007) Yan-Jiang Wang et al.   NEUROBIOLOGY OF AGING

14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein

(2007) Kazuya Omi et al.   NEUROSCIENCE LETTERS