Use of genetic models of idiopathic hypogonadotrophic hypogonadism in mice and men to understand the mechanisms of disease

Neurokinin B Activates Arcuate Kisspeptin Neurons Through Multiple Tachykinin Receptors in the Male Mouse

(2013) Simon de Croft et al.   ENDOCRINOLOGY

Two Families with Normosmic Congenital Hypogonadotropic Hypogonadism and Biallelic Mutations in KISS1R (KISS1 Receptor): Clinical Evaluation and Molecular Characterization of a Novel Mutation

(2013) Frédéric Brioude et al.   PLoS One

Uncovering Novel Reproductive Defects in Neurokinin B Receptor Null Mice: Closing the Gap Between Mice and Men

(2012) Jasmine J. Yang et al.   ENDOCRINOLOGY

Neurokinin B and the Control of the Gonadotropic Axis in the Rat: Developmental Changes, Sexual Dimorphism, and Regulation by Gonadal Steroids

(2012) F. Ruiz-Pino et al.   ENDOCRINOLOGY

Suppression of the GnRH Pulse Generator by Neurokinin B Involves a κ-Opioid Receptor-Dependent Mechanism

(2012) P. Grachev et al.   ENDOCRINOLOGY

Role of Neurokinin B in the Control of Female Puberty and Its Modulation by Metabolic Status

(2012) V. M. Navarro et al.   JOURNAL OF NEUROSCIENCE

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies: Physiological, Pathophysiological and Therapeutic Implications

(2012) Jacques Young et al.   NEUROENDOCRINOLOGY

InactivatingKISS1Mutation and Hypogonadotropic Hypogonadism

(2012) A. Kemal Topaloglu et al.   NEW ENGLAND JOURNAL OF MEDICINE

GPR54-Dependent Stimulation of Luteinizing Hormone Secretion by Neurokinin B in Prepubertal Rats

(2012) Pasha Grachev et al.   PLoS One

Regulation of NKB Pathways and Their Roles in the Control of Kiss1 Neurons in the Arcuate Nucleus of the Male Mouse

(2011) V. M. Navarro et al.   ENDOCRINOLOGY

Developmental Changes in GnRH Release in Response to Kisspeptin Agonist and Antagonist in Female Rhesus Monkeys (Macaca mulatta): Implication for the Mechanism of Puberty

(2011) Kathryn A. Guerriero et al.   ENDOCRINOLOGY

The Inhibitory Effects of Neurokinin B on GnRH Pulse Generator Frequency in the Female Rat

(2011) James S. Kinsey-Jones et al.   ENDOCRINOLOGY

GnRH-Deficient Phenotypes in Humans and Mice with Heterozygous Variants inKISS1/Kiss1

(2011) Yee-Ming Chan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evidence from the Agonadal Juvenile Male Rhesus Monkey (Macaca mulatta) for the View that the Action of Neurokinin B to Trigger Gonadotropin-Releasing Hormone Release Is Upstream from the Kisspeptin Receptor

(2011) Suresh Ramaswamy et al.   NEUROENDOCRINOLOGY

Normosmic Congenital Hypogonadotropic Hypogonadism Due to TAC3/TACR3 Mutations: Characterization of Neuroendocrine Phenotypes and Novel Mutations

(2011) Bruno Francou et al.   PLoS One

Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat

(2010) Víctor M. Navarro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impact of mutations in kisspeptin and neurokinin B signaling pathways on human reproduction

(2010) Leticia Gontijo Silveira et al.   BRAIN RESEARCH

Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus

(2010) Suresh Ramaswamy et al.   ENDOCRINOLOGY

Hypothalamic Dysfunction in a Female with Isolated Hypogonadotropic Hypogonadism and Compound Heterozygous TACR3 Mutations and Clinical Manifestation in Her Heterozygous Mother

(2010) Maki Fukami et al.   Hormone Research in Paediatrics

TAC3/TACR3Mutations Reveal Preferential Activation of Gonadotropin-Releasing Hormone Release by Neurokinin B in Neonatal Life Followed by Reversal in Adulthood

(2010) Elena Gianetti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations of theKISS1Gene in Disorders of Puberty

(2010) L. G. Silveira et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat

(2010) Y. Wakabayashi et al.   JOURNAL OF NEUROSCIENCE

Human GnRH Deficiency: A Unique Disease Model to Unravel the Ontogeny of GnRH Neurons

(2010) Ravikumar Balasubramanian et al.   NEUROENDOCRINOLOGY

Kisspeptin/Gpr54-Independent Gonadotrophin-Releasing Hormone Activity inKiss1andGpr54Mutant Mice

(2009) Y. M. Chan et al.   JOURNAL OF NEUROENDOCRINOLOGY

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

(2008) A Kemal Topaloglu et al.   NATURE GENETICS

AGPR54-Activating Mutation in a Patient with Central Precocious Puberty

(2008) Milena Gurgel Teles et al.   NEW ENGLAND JOURNAL OF MEDICINE