Article
Allergy
Toshiya Miyake, Gyohei Egawa, Zachary Chow, Ryota Asahina, Masayuki Otsuka, Saeko Nakajima, Takashi Nomura, Rintaro Shibuya, Yoshihiro Ishida, Satoshi Nakamizo, Teruasa Murata, Akihiko Kitoh, Kenji Kabashima
Summary: The magnitude of adaptive cutaneous allergic response depends on the circadian rhythm, which may improve the management of allergic contact dermatitis in humans.
Article
Biochemistry & Molecular Biology
Tatyana A. Druzhkova, Alexander A. Yakovlev, Flora K. Rider, Mikhail S. Zinchuk, Alla B. Guekht, Natalia Gulyaeva
Summary: The study investigates the involvement of the hypothalamic-pituitary-adrenal (HPA) axis, inflammatory processes, and neurotrophic factor systems in the pathogenesis of epilepsy and depressive disorders. The results confirm the role of these systems in both epilepsy and depression and provide new insights into the mechanisms underlying the comorbidity of these two conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yanbin Zheng, Shenglan Wang, Yutong Zhong, Chunhong Huang, Xinjie Wu
Summary: This study investigated the association between A20, NLRP3, tumor-associated macrophage polarization and breast cancer progression. The results showed that interference with A20 inhibited breast cancer cell proliferation, invasion, migration, angiogenesis, and M2-like polarization of macrophages. Interference with A20 also promoted NLRP3 inflammasome activation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Endocrinology & Metabolism
Caitlyn M. Edwards, Inge Estefania Guerrero, Huiyuan Zheng, Tyla Dolezel, Linda Rinaman
Summary: Interoceptive feedback from the body to the brain has a significant impact on motivated behaviors. Fasting, which leads to increased levels of ghrelin, has been shown to reduce avoidance behavior. In this study, male rats were trained in a passive avoidance task and then subjected to overnight food deprivation. The rats were then treated with a ghrelin receptor antagonist before testing. The results showed that the antagonist restored passive avoidance behavior in fasted rats, suggesting that ghrelin signaling plays a role in fasting-induced reduction of avoidance behavior.
NEUROENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Salar Vaseghi, Ali Mostafavijabbari, Mohammad-Sadegh Alizadeh, Reza Ghaffarzadegan, Gita Kholghi, Mohammad-Reza Zarrindast
Summary: This review article discusses the intricate roles of sleep deprivation (SD) in modulating depression. The inconsistent effects of SD on depression have been studied for decades, with a focus on SD duration. However, the inconsistent role of SD seems to be more complicated, and other factors such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), serotonin, cortisol, and tumor necrosis factor-alpha (TNF-alpha) are involved. It was concluded that SD has inconsistent effects on BDNF, VEGF, serotonin, and cortisol levels. The diurnal rhythm of BDNF is significant in the modulatory role of SD in depression. VEGF is important in blood-brain barrier permeability which affects depression. Furthermore, there is a negative correlation between cortisol and BDNF, modulating depression. TNF-alpha regulates sleep/wake cycle and increases blood-brain barrier permeability, resulting in depressive behavior. Future studies should focus on these mechanisms/factors to better understand the complex roles of SD in modulating depression.
METABOLIC BRAIN DISEASE
(2023)
Article
Immunology
Mirjana Dimitrijevic, Nevena Arsenovic-Ranin, Dusko Kosec, Biljana Bufan, Mirjana Nacka-Aleksic, Ivan Pilipovic, Gordana Leposavic
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Franca Marino, Marco Cosentino
CURRENT MEDICINAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Mirjana Dimitrijevic, Nevena Arsenovic-Ranin, Dusko Kosec, Biljana Bufan, Mirjana Nacka-Aleksic, Ivan Pilipovic, Gordana Leposavic
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Mirjana Dimitrijevic, Nevena Arsenovic-Ranin, Biljana Bufan, Mirjana Nacka-Aleksic, Dusko Kosec, Ivan Pilipovic, Jelena Kotur-Stevuljevic, Ljubica Simic, Jelena Sopta, Gordana Leposavic
Article
Multidisciplinary Sciences
Jasmina Djuretic, Mirjana Dimitrijevic, Marija Stojanovic, Jelena Kotur Stevuljevic, Michael R. Hamblin, Ana Micov, Radica Stepanovic-Petrovic, Gordana Leposavic
Summary: This study found that rats housed in cages with bedding composed of Celliant fibers containing ceramic particles showed delayed onset and milder severity of collagen-induced arthritis compared to control rats. This could be attributed to lower levels of anti-collagen antibodies and reduced production of IL-17 in the paw tissues of the Celliant fiber group. Additionally, the infrared radiation from Celliant fibers exerted anti-inflammatory effects independently of immunomodulation, as shown in rats with carrageenan-induced paw inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Milica Lazarevic, Neda Djedovic, Suzana Stanisavljevic, Mirjana Dimitrijevic, Goran Stegnjaic, Gurumoorthy Krishnamoorthy, Marija Mostarica Stojkovic, Dorde Miljkovic, Bojan Jevtic
Summary: Experimental autoimmune encephalomyelitis (EAE) induced with complete Freund's adjuvant (CFA) as a model for multiple sclerosis has confounding factors, while immunization with syngeneic spinal cord homogenate (SCH) results in higher symptom accumulation and increased immune cell infiltration without CFA.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Review
Immunology
Dorde Miljkovic, Bojan Jevtic, Ivana Stojanovic, Mirjana Dimitrijevic
Summary: ILC3 has been shown to play a crucial role in regulating Treg cells and counteracting pathogenic cells, as well as stabilizing the intestinal barrier and shaping immune responses to the gut microbiota. Understanding the role of ILC3 in the gut-CNS axis and its implications for MS pathogenesis may offer new therapeutic strategies for MS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Stanislava Stanojevic, Veljko Blagojevic, Ivana Curuvija, Vesna Vujic
Summary: Gut microbiota play a role in shaping the host's immune repertoire, and probiotics may have beneficial effects by modulating immune responses. The response to probiotics can vary between different rat strains, potentially due to differences in their innate immunity.
Article
Immunology
Zorica Stojic-Vukanic, Ivan Pilipovic, Nevena Arsenovic-Ranin, Mirjana Dimitrijevic, Gordana Leposavic
Summary: With aging, the balance between self-reactive T cells and regulatory T cells may shift, impacting the incidence of autoimmune diseases. Gender also plays a significant role in these age-related changes.
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Goran Stegnjaic, Milica Lazarevic, Dimitrios A. Diamantis, Neda Djedovic, Bojan Jevtic, Suzana Stanisavljevic, Mirjana Dimitrijevic, Miljana Momcilovic, Andreas G. Tzakos, Dorde Miljkovic
Summary: This study evaluated the immunomodulatory properties of a phenethyl ester derivative of rosmarinic acid (PERA) in an animal model of central nervous system autoimmunity. PERA was found to have anti-encephalitogenic effects by shortening disease duration and reducing clinical scores, as well as inhibiting the production of encephalitogenic cytokines and nitric oxide. The study suggests that PERA could be a potential therapy for multiple sclerosis.
IMMUNOLOGY LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Raffaella Bombelli, Denisa Baci, Lorenzo Mortara
Summary: Growing evidence suggests that alterations in microbiota composition may play a crucial role in the occurrence, development, and prognosis of prostate cancer. The use of biological technologies has enabled the study of the microbiome signature in the gut, urinary tract, and prostate and its correlation with inflammation, host immunity response, and cancer progression. Understanding the complex interactions between the microbiome and prostate cancer could lead to improved treatment approaches and patient outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Goran Stegnjaic, Antonios D. Tsiailanis, Milica Lazarevic, Vasileios K. Gkalpinos, Neda Djedovic, Thomas Antoniou, Suzana Stanisavljevic, Mirjana Dimitrijevic, Miljana Momcilovic, Dorde Miljkovic, Andreas G. Tzakos, Bojan Jevtic
Summary: Gallic acid, a phenolic acid found in various plants, nuts, and fruits, has anti-oxidative and anti-inflammatory properties. Its phenethyl ester, PEGA, reduces the release of inflammatory substances and ameliorates an animal model of central nervous system inflammatory disease.
Review
Biochemistry & Molecular Biology
Daniela Gallo, Denisa Baci, Natasa Kustrimovic, Nicola Lanzo, Bohdan Patera, Maria Laura Tanda, Eliana Piantanida, Lorenzo Mortara
Summary: Vitamin D plays a vital role in bone health and is involved in various cellular processes. It has been found to have clinical implications in immune surveillance against infections and autoimmune/inflammatory diseases. Recent research has focused on the role of innate immune cells and their interaction with vitamin D and acquired immune cells in the onset and regulation of certain autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Immunology
Veljko Blagojevic, Vesna Vujic, Ivana Curuvija, Katarina Veljovic, Svetlana Sokovic Bajic, Stanislava Stanojevic
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)