Article
Computer Science, Hardware & Architecture
Jingyan She, Peng Du
Summary: The new international video compression standard HEVC calculates increasing complexity to improve compression efficiency, with motion estimation being the most complex arithmetic unit in video encoders. HLS algorithms are successfully used for digital signal processing on FPGAs, and the standard is mainly used for sports video management, target detection, video acquisition, and target tracking.
MICROPROCESSORS AND MICROSYSTEMS
(2021)
Article
Multidisciplinary Sciences
Tingke Tian, Quanzhong Yang, Cuijuan Zhang, Xiaokun Li, Jiancheng Cheng
Summary: MiR-107 is significantly increased in PC cells, promoting proliferation, invasion, and migration. It directly down-regulates TGFBR3 expression by binding to TGFBR3 3'UTR. High miR-107 expression in PC patients is associated with poorer prognosis based on TCGA survival analysis.
Article
Engineering, Biomedical
Ruslan Garifullin, Mustafa O. Guler
Summary: This review discusses the use of self-assembling peptide molecules and electroactive units in supramolecular functional electronic and optical materials, with potential biomedical and bioelectronics applications.
MATERIALS TODAY BIO
(2021)
Review
Biochemistry & Molecular Biology
Traian Constantin, Mihai Pavalean, Stefana Bucur, Maria Magdalena Constantin, Alin Codrut Nicolescu, Irina Pacu, Victor Madan
Summary: Bladder cancer animal models can be categorized as either autochthonous or non-autochthonous, with the non-autochthonous models further classified into syngeneic and xenograft models. These models have different characteristics and applications based on the type of tumor implantation.
Article
Computer Science, Hardware & Architecture
Yixia Zhou, Min Ouyang, Shan Shu
Summary: Artificial intelligence embedded developers aim to provide innovative solutions, crucial for cyber-physical systems like robots and autonomous vehicles. The development of artificial intelligence not only promotes sustainable development in society and the economy, but also opens up new experiences and services for the future.
MICROPROCESSORS AND MICROSYSTEMS
(2021)
Article
Biochemistry & Molecular Biology
Alana N. Vagnozzi, Jian-Guo Li, Jin Chiu, Roshanak Razmpour, Rebecca Warfield, Servio H. Ramirez, Domenico Pratico
Summary: VPS35 plays a crucial role in tau metabolism and neuropathology, with its overexpression reducing pathological tau in neuronal cells while genetic silencing leads to accumulation. The availability of active cathepsin D mediates the effect of VPS35 on pathological tau accumulation, making it a potential therapeutic target for human tauopathies.
MOLECULAR PSYCHIATRY
(2021)
Article
Computer Science, Hardware & Architecture
Ting Chen
Summary: The smart education system is a smaller mirror version of intelligent cities, with intelligent campuses receiving more research and attention worldwide. While existing smart campus concepts are largely technology-driven, more integration is needed to meet the needs and interests of community partners.
MICROPROCESSORS AND MICROSYSTEMS
(2021)
Article
Physics, Multidisciplinary
Gabriel Koch Ocker
Summary: This study presents a statistical field theory for networks of integrate-and-fire neurons with stochastic spike emission, revealing the impact of spike-driven reset of the membrane voltage on population activity. The study uncovers bistability and fluctuation effects in the mean-field dynamics, as well as the roles of spike resets and recurrent inhibition in stabilizing network activity. It also calculates the phase diagram for inhibitory stabilization and finds that wide regions of parameter space exhibit inhibition-stabilized regime.
Article
Engineering, Chemical
James Dufty, Jeffrey Wrighton, Kai Luo
Summary: This article considers definitions for local pressure in an inhomogeneous fluid, covering both equilibrium and local equilibrium states, and reconciles thermodynamic and mechanical (hydrodynamic) contexts. Remaining problems and uncertainties in the topic are also discussed.
Article
Multidisciplinary Sciences
Peter C. Chu
Summary: In ocean dynamics, two different treatments are found for horizontal pressure gradient force and gravity, with vertical component being much larger than horizontal in both cases. Horizontal pressure gradient force is considered dominant, while horizontal gravity is completely omitted in oceanography. The importance of horizontal gravity is identified using a non-dimensional C number, with global data showing an unexpectedly large C number around 24.
SCIENTIFIC REPORTS
(2021)
Article
Education & Educational Research
Olga Garanina, Nidal Al Said, Valery Stepenko, Marija Troyanskaya
Summary: The study developed and tested an original model illustrating personality development in the information society, finding that its implementation increased students' use of resources for personal growth. The model's practical value lies in its applicability to higher education systems in various countries, especially in the context of distance learning and social isolation caused by the COVID-19 pandemic.
EDUCATION AND INFORMATION TECHNOLOGIES
(2021)
Article
Agricultural Engineering
Jiangkuan Xing, Ryoichi Kurose, Kun Luo, Jianren Fan
Summary: Researchers have developed a new tool for establishing solid fuel conversion kinetics from thermogravimetric analysis (TGA) measurements using chemistry-informed machine learning approaches. The derived pyrolysis kinetics accurately reproduce the pyrolysis process for different biomass types and demonstrate advantages in predicting volatiles yield.
BIORESOURCE TECHNOLOGY
(2022)
Article
Computer Science, Hardware & Architecture
Qiong Liu, Hao Peng, Jifeng Chen, Shun Yang
Summary: Face detection system improves accuracy by recognizing facial expressions, describing contours to provide better feature detection. Experimental results show that 97.4% of the samples were successfully recognized for face and face recognition using the FEID database.
MICROPROCESSORS AND MICROSYSTEMS
(2021)
Article
Computer Science, Hardware & Architecture
Like Yang, Wei Yan
Summary: Urban ecological forestry is a leading cause of high global mortality due to the destruction of forest habitats and loss of biodiversity. Detecting and addressing affected areas early is crucial to prevent further damage. The use of Programmable Gate Array in image processing systems can accelerate forest detection and loss detection, improving efficiency and accuracy.
MICROPROCESSORS AND MICROSYSTEMS
(2021)
Article
Computer Science, Hardware & Architecture
Hongtao Deng
Summary: Remote sensors are increasingly being used in complex and diverse applications in the fields of biomedicine and sports, for assembly, measurement, and identification of specific parts of the human body, including diagnostics, recovery, and real-time monitoring. However, these applications are currently only described in detail in two research areas, leaving room for further exploration and research in other fields.
MICROPROCESSORS AND MICROSYSTEMS
(2021)
Review
Cardiac & Cardiovascular Systems
Lin Wu, James R. Sowers, Yingmei Zhang, Jun Ren
Summary: Cardiovascular diseases (CVDs) are caused by abnormalities in the genomic, proteomic, and metabolomic aspects. Recent evidence has confirmed the presence of DNA damage in various CVDs. DNA damage triggers a cellular response called DNA damage response (DDR), which can be beneficial for cardiovascular function temporarily, but persistent activation of DDR promotes the onset and development of CVDs. Therefore, targeting DNA damage and DDR could potentially improve cardiovascular dysfunction and disease outcome.
CARDIOVASCULAR RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Amir Ajoolabady, Neil Kaplowitz, Cynthia Lebeaupin, Guido Kroemer, Randal J. Kaufman, Harmeet Malhi, Jun Ren
Summary: The endoplasmic reticulum stress and unfolded protein response play important roles in the pathophysiology of liver diseases. Understanding this process is crucial for developing interventions for the treatment of nonmalignant liver diseases.
Review
Pharmacology & Pharmacy
Hemalatha Selvaraj, Kumudha Damadarosamy, Natarajan Kiruthiga, K. Reeta Vijaya Rani, Kanagaraj Duraisamy, Muralikrishnan Dhanasekaran, Jack Deruiter, Jun Ren, Sivakumar Thangavel, Rachel Parise
Summary: This review discusses the coexistence of COVID-19 and tuberculosis, highlighting the impact on respiratory symptoms and treatment outcomes. The lack of data on COVID-19 infection in TB patients may lead to inadequate response to drug therapy, particularly when TB treatment is interrupted. Measures should be taken to minimize transmission in community and healthcare settings, and accurate diagnostic testing and well-designed therapeutic strategies are necessary for effective treatment.
CURRENT DRUG SAFETY
(2023)
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Ali Zarrabi, Hassan Karimi-Maleh, Afshin Taheriazam, Sepideh Mirzaei, Mehrdad Hashemi, Kiavash Hushmandi, Pooyan Makvandi, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Arul Goel, Lingzhi Wang, Jun Ren, Yavuz Nuri Ertas, Alan Prem Kumar, Yuzhuo Wang, Navid Rabiee, Gautam Sethi, Zhaowu Ma
Summary: Nanomedicine has great potential in the treatment of bladder cancer, including improving drug efficacy, regulating gene expression, providing photodynamic and photothermal therapy, remodeling tumor microenvironment and infiltration of immune cells, timely diagnosis, and targeted therapy for bladder cancer.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Qiong Liu, Yushu Dong, Germaine Escames, Xue Wu, Jun Ren, Wenwen Yang, Shaofei Zhang, Yanli Zhu, Ye Tian, Dario Acuna-Castroviejo, Yang Yang
Summary: This study systematically clarified the mechanisms of melatonin (MEL) in improving septic myocardial injury, and identified PIK3CG as a promising target for therapeutic intervention. The findings provide valuable information for the management of septic myocardial injury.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Huan Zhang, Zi-Yin Zhang-Sun, Cheng-Xu Xue, Xi-Yang Li, Jun Ren, Yu-Ting Jiang, Tong Liu, Hai-Rong Yao, Juan Zhang, Tian-Tian Gou, Ye Tian, Wang-Rui Lei, Yang Yang
Summary: This article introduces the characteristics and functions of the C1q/TNF-related protein family in inflammation and metabolism. It focuses on the structure, function, and relationship of the CTRP family with inflammation, metabolism, and related diseases. This information provides new therapeutic strategies for improving inflammatory and metabolic abnormalities.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Oncology
Amir Ajoolabady, Daolin Tang, Guido Kroemer, Jun Ren
Summary: Hepatocellular carcinoma is a prevalent form of liver cancer, with genetic, environmental, and behavioral factors influencing its development. Ferroptosis, a form of nonapoptotic cell death, has potential for suppressing hepatocellular carcinoma. However, malignant cells can develop mechanisms to resist ferroptosis.
BRITISH JOURNAL OF CANCER
(2023)
Review
Chemistry, Medicinal
Amir Ajoolabady, Cynthia Lebeaupin, Ne N. Wu, Randal J. Kaufman, Jun Ren
Summary: This study aims to elucidate the relationship between ER stress and inflammation in obesity, and summarize potential therapeutic strategies for managing obesity through manipulating ER stress and ER stress-associated inflammation.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Medicine, Research & Experimental
Jie Min, Lin Wu, Yandong Liu, Guoliang Song, Qinqin Deng, Wei Jin, Wei Yu, Miyesaier Abudureyimu, Zhaohui Pei, Jun Ren
Summary: This study evaluated the impact of SGLT2 inhibitor Empagliflozin on TZM-induced cardiotoxicity and explored the mechanism involving DNA damage and ferroptosis. The results showed that Empagliflozin markedly attenuated TZM-induced cardiac damage and may function through a DNA damage-ferroptosis-mediated mechanism.
Review
Pharmacology & Pharmacy
Lin Wu, Litao Wang, Yuxin Du, Yingmei Zhang, Jun Ren
Summary: Doxorubicin (DOX) is effective in treating solid tumors and hematologic malignancies but its clinical application is limited by its cardiotoxicity. Defective mitochondrial quality control has been found to play a major role in the development of DOX-induced cardiomyopathy. Targeting these quality control mechanisms has emerged as a potential therapeutic strategy to attenuate DOX cardiotoxicity. However, clinical translation is challenging due to obscure mechanisms of action and potential adverse effects.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Correction
Pharmacology & Pharmacy
Shuyi Wang, Jun Tao, Huaguo Chen, Machender R. Kandadi, Mingming Sun, Haixia Xu, Gary D. Lopaschuk, Yan Lu, Junmeng Zheng, Hu Peng, Jun Ren
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Huadong Zhao, Ying Chen, Lu Qian, Luyang Du, Xue Wu, Ye Tian, Chao Deng, Shuai Liu, Wenwen Yang, Chenxi Lu, Yan Zhang, Jun Ren, Yang Yang
Summary: This study evaluates the effect of LYC pre- and post-treatment in a septic mouse model and its potential mechanism. LYC pretreatment attenuates myocardial injury by improving survival rate, sepsis score, blood indicators, cardiac function, inhibiting inflammation and oxidative stress, improving mitochondrial function, modulating ER stress, and activating AMPK pathway. LYC posttreatment also has slight protective effects on septic myocardial injury, but not as ideal as pretreatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yanyan Ma, Jipeng Ma, Linhe Lu, Xiang Xiong, Yalan Shao, Jun Ren, Jian Yang, Jiankang Liu
Summary: Melatonin protects the heart against doxorubicin-induced injury by restoring autophagic flux.
Review
Biochemistry & Molecular Biology
Mehrdad Hashemi, Eisa Sabouni, Parham Rahmanian, Maliheh Entezari, Mahsa Mojtabavi, Behnaz Raei, Mohammad Arad Zandieh, Mitra Behroozaghdam, Sepideh Mirzaei, Kiavash Hushmandi, Noushin Nabavi, Shokooh Salimimoghadam, Jun Ren, Mohsen Rashidi, Rasoul Raesi, Afshin Taheriazam, Athanasios Alexiou, Marios Papadakis, Shing Cheng Tan
Summary: Hepatocellular carcinoma (HCC) is a common form of liver cancer and poses a great challenge to human life. Targeting the molecular signaling pathways through STAT3 may provide new and effective therapies for HCC. This review discusses the expression and phosphorylation status of STAT3 in HCC, highlighting its role as an oncogenic factor that prevents apoptosis and promotes cancer progression.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Ne N. Wu, Lifeng Wang, Lu Wang, Xihui Xu, Gary D. Lopaschuk, Yingmei Zhang, Jun Ren
Summary: Researchers in China have discovered that an enzyme called Parkin can restrict the release of DNA from mitochondria, thereby preventing liver fibrosis. Enhancing the protective ability of Parkin could lead to new therapeutic approaches for liver disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)