Article
Microbiology
Fernando A. Vicentini, Catherine M. Keenan, Laurie E. Wallace, Crystal Woods, Jean-Baptiste Cavin, Amanda R. Flockton, Wendy B. Macklin, Jaime Belkind-Gerson, Simon A. Hirota, Keith A. Sharkey
Summary: The study demonstrates the role of the gut microbiota in regulating the structure and function of the GI tract in a sex-independent manner. The microbiota is essential for maintaining ENS integrity by regulating enteric neuronal survival and promoting neurogenesis. Molecular determinants such as LPS and SCFA play a key role in regulating enteric neuronal survival and neurogenesis.
Article
Biochemical Research Methods
Alex Gonzalez-Vergara, Benjamin Benavides, Marcela Julio-Pieper
Summary: Neuropeptides are diverse signaling molecules found in the central and peripheral nervous systems, including the enteric nervous system. Studying their role in diseases and therapeutic potential requires addressing analytical challenges, particularly in the low abundance of neuropeptides in the ENS tissue. This review discusses these challenges and opportunities for technical development.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Medicine, Research & Experimental
Lucas Casagrande, Maria Jose Pastre, Aline Rosa Trevizan, Roberto Kenji Nakamura Cuman, Ciomar Aparecida Bersani-Amado, Joao Luis Garcia, Marcelo Biondaro Gois, Debora de Mello Goncales Sant'Ana, Gessilda de Alcantara Nogueira-Melo
Summary: This study investigated the effects of acute oral infection with T. gondii on the intestinal tissue structure, enteric nervous system, and inflammatory markers in mice. The results showed a significant increase in serotonin-immunoreactive cells and inflammation in the intestinal mucosa and neural tissue. This study contributes to the understanding of the pathophysiological mechanisms of intestinal inflammation in humans.
Review
Physiology
Keith A. Sharkey, Gary M. Mawe
Summary: The gastrointestinal tract is the most complex organ system in the body, controlling digestion and defense functions through the enteric nervous system. This system interacts with the immune system, gut microbiota, and epithelium to maintain mucosal defense and barrier function. Recent developments have improved our understanding of the molecular architecture, function, and regulation of the enteric nervous system, highlighting its importance in maintaining intestinal homeostasis.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Neurosciences
Jean-Baptiste Cavin, Preedajit Wongkrasant, Joel B. Glover, Onesmo B. Balemba, Wallace K. MacNaughton, Keith A. Sharkey
Summary: The enteric nervous system regulates the functions of the gastrointestinal tract, and its response to changes in the gut lumen is not well understood. This study used live-cell confocal recordings to investigate neuronal response to luminal mechanical and chemical stimuli. The results show that intestinal distension regulates the excitability of enteric neural circuits via mechanosensitive channels, and the content of the intestinal lumen dynamically regulates the excitability of enteric neural circuits.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Ines Hecking, Lennart Norman Stegemann, Verena Theis, Matthias Vorgerd, Veronika Matschke, Sarah Stahlke, Carsten Theiss
Summary: Research has found that the enteric nervous system (ENS), through its connection to the microbiome and the immune system, may play a role in the pathological changes seen in neurodegenerative diseases. Vascular endothelial growth factor (VEGF) has shown neuroprotective effects in both the central and peripheral nervous systems, and can directly protect enteric neurons in the ENS. These findings suggest a promising approach for neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Zitong Huang, Lu Liao, Zhesheng Wang, Yulin Lu, Weiming Yan, Hongying Cao, Bo Tan
Summary: This study presents a simple and rapid method for preparing whole mounts of rat colon, facilitating the easy separation of LMMPs and allowing clear visualization of structures through immunofluorescence staining. Compared to existing methods, this approach is more efficient and provides sufficient high-quality LMMPs in a quicker manner.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Gastroenterology & Hepatology
Wai Ping Yew, Adam Humenick, Bao Nan Chen, David A. Wattchow, Marcello Costa, Phil G. Dinning, Simon J. H. Brookes
Summary: Ex vivo intracellular recordings and dye fills, combined with immunohistochemistry, are used to analyze the enteric nervous system of laboratory animals. Treatment with a collagenase/neutral protease mix improves recording success and reduces damage. Most dye-filled myenteric neurons are uni-axonal, and there is a low correlation between morphology and electrophysiology. Neurons immunoreactive for nitric oxide synthase are more excitable and distinctive grooves on the neuron surface may represent preferential sites of synaptic inputs.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Biochemistry & Molecular Biology
Laura Lopez-Pingarron, Henrique Almeida, Marisol Soria-Aznar, Marcos C. Reyes-Gonzales, Ana B. Rodriguez-Moratinos, Antonio Munoz-Hoyos, Joaquin J. Garcia
Summary: The enteric nervous system (ENS) consists of two plexuses, submucosal and myenteric, which regulate gastrointestinal motility through communication with interstitial cells of Cajal (ICCs). ICCs generate slow waves that control smooth muscle contraction and are involved in enteric neurotransmission. Oxidative stress and neurological diseases can disrupt the interaction between ICCs, the ENS, and the central nervous system (CNS), leading to gastrointestinal motility disorders. This review discusses disturbances in enteric neurotransmission and ICC function that contribute to abnormal gut motility.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Medicine, General & Internal
Marine Mantel, Pascal Derkinderen, Kalyane Bach-Ngohou, Michel Neunlist, Malvyne Rolli-Derkinderen
Summary: The enteric nervous system (ENS) is able to integrate signals to accurately regulate digestive functions. The ENS produces n-6 oxylipins, derived from arachidonic acid, which play a major role in various physiological processes. The study of these oxylipins on digestive functions and their interaction with the ENS is expanding.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Annalisa Bosi, Davide Banfi, Federico Moroni, Chiara Ceccotti, Maria Cecilia Giron, Micaela Antonini, Cristina Giaroni, Genciana Terova
Summary: In this study, the effect of partially substituting fishmeal with black soldier fly larvae meal on the neuromuscular function of gilthead sea bream's intestines was evaluated. The results showed that the insect meal had no significant impact on growth parameters and intestinal morphology, but it did affect gastrointestinal transit, muscle fiber excitatory and inhibitory transmission, and chemical coding.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Giulia Bernabe, Mahmoud Elsayed Mosaad Shalata, Veronica Zatta, Massimo Bellato, Andrea Porzionato, Ignazio Castagliuolo, Paola Brun
Summary: The side effects of antibiotic treatment are directly related to intestinal dysbiosis. This study examined the long-term effects of antibiotic-induced dysbiosis on the enteric nervous system and the impact of spontaneous restoration of gut microbiota on gastrointestinal functions. Two weeks of antibiotic treatment significantly altered gut microbial composition, and some bacterial genera did not regain their abundance after six weeks of discontinuation.
Article
Neurosciences
Beatriz Thomasi, Luisa Valdetaro, Brian Gulbransen, Ana Lucia Tavares-Gomes
Summary: The gastrointestinal tract, as the largest immune organ, plays a crucial role in the pathogenesis of diseases such as Parkinson's disease by interacting with the neural systems.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Veterinary Sciences
Roberto Chiocchetti, Giorgia Galiazzo, Fiorella Giancola, Claudio Tagliavia, Chiara Bernardini, Monica Forni, Marco Pietra
Summary: The distribution of serotonin transporter immunoreactivity in the dog intestine is similar to that in rats and humans, suggesting a conserved role in serotonin reuptake mechanism.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Julia Doroszkiewicz, Magdalena Groblewska, Barbara Mroczko
Summary: The interaction between the gut microbiome and the brain plays a significant role in the development of neurological disorders, including neurodegenerative diseases and neuropsychological disorders. Balanced gut microbiota composition presents new potential opportunities for therapeutic interventions in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Natalia Maria Maciel Guerra-Silva, Fernanda Sene Santucci, Ricardo Castanho Moreira, Cristiano Massao Tashima, Simone Cristina Castanho Sabaini de Melo, Leonardo Regis Leira Pereira, Debora de Mello Goncales Sant'Ana
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Gastroenterology & Hepatology
L. C. L. Schneider, J. C. P. do Nascimento, A. R. Trevizan, M. B. Gois, S. C. Borges, E. J. Beraldi, J. L. Garcia, D. M. G. Sant'Ana, N. C. Buttow
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Medicine, Research & Experimental
Mariana Felgueira Pavanelli, Cristiane Maria Colli, Monica Lucia Gomes, Marcelo Biondaro Gois, Gessilda de Alcantara Nogueira de Melo, Eduardo Jose de Almeida Araujo, Debora de Mello Goncales Sant'Ana
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Parasitology
Daniele S. Rocha, Mariana G. Nilsson, Bianca M. Maciel, Hilda F. J. Pena, Bruna F. Alves, Aristeu Silva, Luis F. P. Gondim, George R. Albuquerque
JOURNAL OF PARASITOLOGY
(2018)
Article
Neurosciences
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R. Tough, Paulo Watanabe, Eduardo J. A. Araujo, Sahar D. Mohammed, Jean-Marie Delalande, David C. Bulmer, S. Mark Scott, Helen M. Cox, Nicol C. Voermans, Qasim Aziz, L. Ashley Blackshaw
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Parasitology
Mariana Felgueira Pavanelli, Cristiane Maria Colli, Renata Coltro Bezagio, Marcelo Biondaro Gois, Gessilda de Alcantara Nogueira de Melo, Eduardo Jose de Almeida Araujo, Debora de Mello Goncales Sant'Ana
PARASITOLOGY RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Aline Rosa Trevizan, Larissa Carla Lauer Schneider, Eduardo Jose de Almeida Araujo, Joao Luis Garcia, Nilza C. Buttow, Gessilda de Alcantara Nogueira-Melo, Debora de Mello Goncales Sant'Ana
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Chemistry, Medicinal
Camile Cecconi Cechinel-Zanchett, Thaise Boeing, Lincon Bordignon Somensi, Viviane Miranda Bispo Steimbach, Adriana Campos, Clarissa de Medeiros Amorm Krueger, Cristiany Schultz, Debora de Mello Goncales Sant'ana, Valdir Cechinel-Filho, Luisa Mota da Silva, Sergio Faloni de Andrade
PHYTOTHERAPY RESEARCH
(2019)
Article
Parasitology
Adriana Lebram von Sohsten, Aristeu Vieira da Silva, Guita Rubinsky-Elefant, Ilmara Simony Freitas Santana, Joelande Esquivel Correia, Luciara Alves da Cruz, Ellen Monteiro Ribeiro Santos, Priscylla Marcelly Vilanova Oliveira
EXPERIMENTAL PARASITOLOGY
(2020)
Review
Economics
Lays P. Marra, Ana L. Sartori, Martha S. Martinez-Silveira, Cristiana M. Toscano, Ana L. Andrade
Summary: This study aimed to evaluate the effectiveness of pneumococcal vaccines on otitis media and acute otitis media in children. The results showed that pneumococcal vaccines play an important role in reducing the incidence of otitis media in children.
Article
Infectious Diseases
Tatiana Salerno, Amanda Keller Siqueira, Jose Paes de Almeida Nogueira Pinto, Maria de Lourdes Ribeiro de Souza da Cunha, Patricia Kelly Silvestre, Larissa Anuska Zeni Condas, Gustavo Henrique Batista Lara, Juliano Goncalves Pereira, Aristeu Vieira da Silva, Fernando Jose Paganini Listoni, Lorrayne de Souza Araujo Martins, Rodrigo Garcia Motta, Marcio Garcia Ribeiro
Summary: The study investigated the bacteriological and physical-chemical characteristics, as well as genotypic and phenotypic profiles of Staphylococcus species in breast milk samples from a hospital milk bank. It found that Staphylococcus and Enterobacter were the most prevalent genera, with high resistance rates to certain antimicrobials. Additionally, genes associated with toxin production and multidrug resistance were identified in the isolated bacteria. The presence of microbial multiplication inhibitory substances in a high percentage of samples highlighted the need for continuous monitoring of the quality of milk provided to infants from human milk banks.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2021)
Article
Microbiology
Thiago de Oliveira Zamprogna, Dayana Ribeiro, Vasco A. C. Azevedo, Gustavo Henrique Batista Lara, Rodrigo Garcia Motta, Rodrigo Costa da Silva, Amanda Keller Siqueira, Geraldo de Nardi Junior, Fernando Jose Paganini Listoni, Lorrayne de Souza Araujo Martins, Aristeu Vieira da Silva, Fabio Vinicius Ramos Portilho, Andre da Rocha Mota, Carolina Aparecida Rodrigues, Beatriz Oliveira de Almeida, Marcio Garcia Ribeiro
Summary: Caseous lymphadenitis in sheep is a chronic contagious disease caused by Corynebacterium pseudotuberculosis, diagnosed through cytology and microbiological testing, while molecular methods are confirmatory. The study also identified other bacteria in lymph nodes, posing potential diagnostic challenges.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Marcelo Alberto Elias, Mariana Felgueira Pavanelli, Gessilda de Alcanara Nogueira de Melo, Debora de Mello Goncales Sant'Ana
SEMINA-CIENCIAS AGRARIAS
(2020)
Article
Parasitology
Pedro de Alcantara Brito Junior, Josiane Moreira Rocha, Caroline Araujo da Silva, Priscylla Marcelly Vilanova Oliveira, Joelande Esquivel Correia, Luciara Alves da Cruz, Anaia Paixao Seva, Teo Veiga de Oliveira, Aristeu Vieira da Silva, Martin Roberto del Valle Alvarez, George Rego Albuquerque
REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA
(2020)