Journal
EXPERIMENTAL PARASITOLOGY
Volume 120, Issue 4, Pages 397-402Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2008.09.014
Keywords
Mitochondria; Heart; Trypanosoma cruzi; Respiratory chain; Ultrastructure
Categories
Funding
- Secretaries of Science and Technology (SECYT)
- Universidad Nacional de Cordoba
- Universidad Nacional de La Rioja
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The parasite Trypanosoma cruzi is the causative agent of Chagas disease. T. cruzi invasion and replication in cardiomyocytes induce cellular injuries and cytotoxic reactions, with the production of inflammatory cytokines and nitric oxide, both source of reactive oxygen species. The myocyte response to oxidative stress involves the progression of cellular changes primarily targeting mitochondria. We studied the cardiac mitochondrial structure and the enzymatic activity of citrate synthase and respiratory chain CI-CIV complexes, in Albino Swiss mice infected with T. cruzi. Tulahuen strain and SGO Z12 isolate, in two periods of the acute infection. Changes in the mitochondrial structure were detected in both infected groups, reaching values of 71% for Tulahuen and 88% for SGO Z12 infected mice, 30 days post infection. The citrate synthase activity was different according to the evolution of the infection and the parasite strain, but the respiratory chain alterations were similar with either strain. (C) 2008 Elsevier Inc. All rights reserved.
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