Article
Medicine, General & Internal
Carlo Bienkowski, Malgorzata Aniszewska, Monika Kowalczyk, Jolanta Popielska, Konrad Zawadka, Agnieszka Oldakowska, Maria Pokorska-Spiewak
Summary: This study aimed to evaluate the risk factors associated with Toxoplasma gondii infection in pregnant women. The results showed that living in rural areas and eating raw meat were independent risk factors for T. gondii infection during pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Lokman Galal, Frederic Ariey, Meriadeg Ar Gouilh, Marie-Laure Darde, Azra Hamidovic, Franck Letourneur, Franck Prugnolle, Aurelien Mercier
Summary: This study analyzes 156 genomes of Toxoplasma gondii and provides estimates of the parasite's mutation rate and generation time. It reveals that a specific haplotype is associated with the spread of the parasite through cats, indicating its role in sexual reproduction.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Arwa Lachkhem, Lokman Galal, Ibtissem Lahmar, Karine Passebosc, Homayoun Riahi, Nicolas Plault, Marie-Laure Darde, Aurelien Mercier, Hamouda Babba
Summary: Isolation and genetic characterization of Toxoplasma gondii strains from domestic animals in Southern and coastal area of Tunisia revealed a large predominance of type II strains, followed by type III, and for the first time in Tunisia, an isolate of Africa 4 lineage. Analyses of population genetics also showed the presence of a divergent population of type II lineage in Tunisia, supporting limited recent migrations of strains between Tunisia and other countries.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T. Baldridge, Thaddeus Stappenbeck, Marco Colonna, L. David Sibley
Summary: Oral infection with Toxoplasma gondii exacerbates damage to the colon caused by chemical irritant and impairs wound healing by suppressing stem cell regeneration. Enhanced tissue damage is due to inflammatory monocytes releasing inflammatory mediators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Idessania Nazareth Costa, Mayara Ribeiro, Priscila Silva Franco, Rafaela Jose da Silva, Thadia Evelyn de Araujo, Iliana Claudia Balga Milian, Luana Carvalho Luz, Pamela Mendonca Guirelli, Gerson Nakazato, Jose Roberto Mineo, Tiago W. P. Mineo, Bellisa Freitas Barbosa, Eloisa Amalia Vieira Ferro
Summary: The study revealed that AgNp-Bio can reduce T. gondii infection in trophoblast cells and villous explants, while also increasing the production of inflammatory mediators in the cells.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Heloise Debare, Nathalie Moire, Firmin Baron, Louis Lantier, Bruno Heraut, Nathalie Van Langendonck, Caroline Denevault-Sabourin, Isabelle Dimier-Poisson, Francoise Debierre-Grockiego
Summary: SP230, a specific inhibitor of TgCDPK1, showed significant efficacy in reducing parasite burdens in both dams and foetuses in a mouse model of congenital toxoplasmosis, making it a promising candidate for alternative therapeutics for infected pregnant women.
Review
Food Science & Technology
Pablo-Jesus Marin-Garcia, Nuria Planas, Lola Llobat
Summary: This article reviews the detection methods, prevalence, and control measures of Toxoplasma gondii in the food industry. T. gondii is a common parasite that causes infection through food contamination, but standardized detection methods are currently lacking in the industry. The main detection methods include bioassays, cell culture, molecular and microscopic techniques, and serological methods. Due to the high prevalence of T. gondii in many food products, standardized detection methods and control measures are necessary.
Article
Immunology
Mohammad Mahdi Jafari, Zahra Azimzadeh Tabrizi, Mohammad Saaid Dayer, Nazanin Atieh Kazemi-Sefat, Mahshid Mohtashamifard, Rahimeh Mohseni, Atefeh Bagheri, Saeed Bahadory, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar
Summary: Toxoplasma gondii infection is associated with immune response, which can be used as prognosis markers. Immunotherapy has become a new approach for toxoplasmosis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Rina Ikeda, Nanako Ushio, Ahmed M. Abdou, Hidefumi Furuoka, Yoshifumi Nishikawa
Summary: The study found that TLR2(-/-) mice are less susceptible to abnormal pregnancy induced by Toxoplasma gondii infection compared to wild-type mice. While there were no significant differences in parasite numbers and histological changes between the two groups, the expression of certain cytokines in the placentas of infected wild-type mice was affected by T. gondii infection, while TLR2(-/-) mice showed no such changes. Serum interferon-gamma levels were significantly lower in infected TLR2(-/-) mice, indicating a potential role of TLR2 signaling in immune response and placental function during late pregnancy.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biology
Celine Dard, Christopher Swale, Marie-Pierre Brenier-Pinchart, Dayana C. Farhat, Valeria Bellini, Marie Gladys Robert, Dominique Cannella, Herve Pelloux, Isabelle Tardieux, Mohamed-Ali Hakimi
Summary: Discovery of the protein BCLA/MAG2 as a specific marker for bradyzoite and cyst envelope in T. gondii has been achieved through genetically engineered parasites. By using lab mice as models, researchers have confirmed that BCLA/MAG2 can stimulate antibody production recognizing bradyzoite and cyst structure. An ELISA assay based on a bacterially produced BCLA recombinant polypeptide has been designed and validated using sera from mice and human patients with toxoplasmosis, showing promising results for detection of persistent T. gondii infection.
Article
Biochemistry & Molecular Biology
Samuel Cota Teixeira, Marina Paschoalino, Guilherme de Souza, Alessandra Monteiro Rosini, Joed Pires de Lima Junior, Luana Carvalho Luz, Aryani Felixa Fajardo Martinez, Rosiane Nascimento Alves, Marcos Paulo Oliveira Almeida, Jaqueline Lopes Damasceno, Francesca Ietta, Bellisa Freitas Barbosa, Eloisa Amalia Vieira Ferro, Carlos Henrique Gomes Martins
Summary: This study found that the natural polyphenol Rottlerin has anti-parasitic activity against Toxoplasma gondii infection. Rottlerin impairs the infection and proliferation of the parasite in human trophoblastic cells and villous explants. Its mode of action includes direct effects on the parasite and modulation of host cell components, offering a promising tool for preventing and/or treating congenital toxoplasmosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Parasitology
Jiaofeng Huang, Jiaolong Zheng, Bang Liu, Lingling Lu, Haicong Wu, Su Lin, Dongliang Li
Summary: This study found that Toxoplasma gondii infection is associated with higher mortality in the general population, and this association is related to age and sex. This suggests that Toxoplasma gondii infection may be an important public health issue.
PARASITES & VECTORS
(2022)
Article
Immunology
Guilherme de Souza, Samuel Cota Teixeira, Aryani Felixa Fajardo Martinez, Rafaela Jose Silva, Luana Carvalho Luz, Joed Pires de Lima Junior, Alessandra Monteiro Rosini, Natalia Carine Lima dos Santos, Rafael Martins de Oliveira, Marina Paschoalino, Matheus Carvalho Barbosa, Rosiane Nascimento Alves, Angelica Oliveira Gomes, Claudio Vieira da Silva, Eloisa Amalia Vieira Ferro, Bellisa Freitas Barbosa
Summary: In this study, the impact of T. cruzi and recombinant P21 on T. gondii infection was investigated in BeWo cells and human placental explants. The results showed that T. cruzi infection and rP21 can increase the invasion and decrease the intracellular proliferation of T. gondii in BeWo cells. In human placental villi, rP21 can either increase or decrease T. gondii proliferation, while T. cruzi infection increases T. gondii proliferation. These findings highlight the importance of neonatal screening for both diseases and suggest P21 as a potential therapeutic target for Chagas disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Syrian G. Sanchez, Emilie Bassot, Aude Cerutti, Hoa Mai Nguyen, Amel Aida, Nicolas Blanchard, Sebastien Besteiro
Summary: Toxoplasma gondii is responsible for toxoplasmosis, a disease that can be serious when contracted during pregnancy, but can also be a threat for immunocompromised individuals. The study finds that targeting the apicoplast in bradyzoites, the latent form of the parasite, leads to a loss of long-term viability, suggesting the apicoplast as a potential therapeutic target.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Aryani Felixa Fajardo Martinez, Samuel Cota Teixeira, Guilherme de Souza, Alessandra Monteiro Rosini, Joed Pires de Lima Junior, Gabriel Nogueira Melo, Kelvin Orlando Espinoza Blandon, Angelica Oliveira Gomes, Sergio Ricardo Ambrosio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Carlos Henrique Gomes Martins, Eloisa Amalia Vieira Ferro, Bellisa Freitas Barbosa
Summary: The hydroalcoholic extract and oleoresin from Copaifera multijuga have anti-Toxoplasma gondii activity and do not cause toxicity in human cells. Additionally, they can inhibit adhesion, invasion, and replication of the parasite. These compounds may serve as a new therapeutic strategy for congenital toxoplasmosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Ricardo A. Tapia, Cristian O. Salas, Karina Vazquez, Christian Espinosa-Bustos, Jorge Soto-Delgado, Javier Varela, Estefania Birriel, Hugo Cerecetto, Mercedes Gonzalez, Margot Paulino
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2014)
Review
Chemistry, Medicinal
Martin Gabay, Mauricio Cabrera, Rossanna Di Maio, Juan A. Paez, Nuria Campillo, Maria L. Lavaggi, Hugo Cerecetto, Mercedes Gonzalez
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2014)
Article
Chemistry, Medicinal
Julio Benitez, Aline Cavalcanti de Queiroz, Isabel Correia, Marina Amaral Alves, Magna S. Alexandre-Moreira, Eliezer J. Barreiro, Lidia Moreira Lima, Javier Varela, Mercedes Gonzalez, Hugo Cerecetto, Virtudes Moreno, Joao Costa Pessoa, Dinorah Gambino
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Enrique Torres, Elsa Moreno-Viguri, Silvia Galiano, Goutham Devarapally, Philip W. Crawford, Amaia Azqueta, Leire Arbillaga, Javier Varela, Estefania Birriel, Rossanna Di Maio, Hugo Cerecetto, Mercedes Gonzalez, Ignacio Aldana, Antonio Monge, Silvia Perez-Silanes
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Paola Hernandez, Rosario Rojas, Robert H. Gilman, Michel Sauvain, Lidia M. Lima, Eliezer J. Barreiro, Mercedes Gonzalez, Hugo Cerecetto
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Laura Celano, Claudio Carabio, Renata Frache, Nicolas Cataldo, Hugo Cerecetto, Mercedes Gonzalez, Leonor Thomson
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Chemistry, Medicinal
Nicolas Cataldo, Bruno Musetti, Laura Celano, Claudio Carabio, Adriana Cassina, Hugo Cerecetto, Mercedes Gonzalez, Leonor Thomson
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Parasitology
Andrea Trochine, Guzman Alvarez, Sandra Corre, Paula Faral-Tello, Rosario Duran, Carlos I. Batthyany, Hugo Cerecetto, Mercedes Gonzalez, Carlos Robello
EXPERIMENTAL PARASITOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Guzman Alvarez, Jennyfer Martinez, Beatriz Aguirre-Lopez, Nallely Cabrera, Leticia Perez-Diaz, Marietta Tuena de Gomez-Puyou, Armando Gomez-Puyou, Ruy Perez-Montfort, Beatriz Garat, Alicia Merlino, Mercedes Gonzalez, Hugo Cerecetto
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2014)
Article
Chemistry, Medicinal
Guzman Alvarez, Javier Varela, Pablo Marquez, Martin Gabay, Carmen Elena Arias Rivas, Karina Cuchilla, Gustavo A. Echeverria, Oscar E. Piro, Marlus Chorilli, Sandra M. Leal, Patricia Escobar, Elva Serna, Susana Torres, Gloria Yaluff, Ninfa I. Vera de Bilbao, Mercedes Gonzalez, Hugo Cerecetto
JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Marcos Couto, Mauricio Cabrera, Gustavo A. Echeverria, Oscar E. Piro, Mercedes Gonzalez, Hugo Cerecetto
MOLECULAR DIVERSITY
(2014)
Article
Biochemistry & Molecular Biology
Javier Varela, Elva Serna, Susana Torres, Gloria Yaluff, Ninfa I. Vera de Bilbao, Patricio Mino, Ximena Chiriboga, Hugo Cerecetto, Mercedes Gonzalez
Article
Multidisciplinary Sciences
Nahir Dib, Luciana Fernandez, Marisa Santo, Luis Otero, Fabrisio Alustiza, Ana Cecilia Liaudat, Pablo Bosch, M. Laura Lavaggi, Hugo Cerecetto, Mercedes Gonzalez
Article
Chemistry, Multidisciplinary
Nahir Dib, Luciana Fernandez, Mercedes Gonzalez, Hugo Cerecetto, Edgardo Durantini, Luis Otero, Marisa Santo
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2014)
Article
Chemistry, Medicinal
Angela Guerra, Pedro Gonzalez-Naranjo, Nuria E. Campillo, Hugo Cerecetto, Mercedes Gonzalez, Juan A. Paez
CURRENT COMPUTER-AIDED DRUG DESIGN
(2013)
