Article
Cell Biology
Takuya Hikima, Christian R. Lee, Paul Witkovsky, Julia Chesler, Konstantin Ichtchenko, Margaret E. Rice
Summary: Research suggests that somatodendritic dopamine release in the substantia nigra pars compacta autoinhibits the neuron that releases it.
Article
Neurosciences
Takuya Hikima, Paul Witkovsky, Latika Khatri, Moses Chao, Margaret E. Rice
Summary: This study reveals the critical role of high-affinity Ca2+ sensor synaptotagmin 7 (Syt7) in somatodendritic dopamine (DA) release. Both Syt7 and Syt1 are involved in the release of DA.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Suthinee Attachaipanich, Takaaki Ozawa, Tom Macpherson, Takatoshi Hikidap
Summary: The nucleus accumbens (NAc) is a crucial part of the limbic basal ganglia circuit and is associated with decision-making and reward processing. This study investigated the effects of optogenetic manipulation of the NAc D1-MSN-SNr pathway on reward learning and locomotor behavior in male mice. The results showed that stimulation of this pathway induced a preference for a laser-paired location, self-stimulation, and enhanced instrumental responding for a liquid reward. Furthermore, stimulation increased locomotor behavior when delivered bilaterally and induced contralateral turning behavior when delivered unilaterally. However, inhibition of this pathway had no effect on reward-related behaviors or locomotion.
Article
Neurosciences
Muxin Lin, Ying Wang, Yi Wang, Fujun Chen
Summary: This study investigated the mutual electrophysiological relationship among the subthalamic nucleus (STN), substantia nigra pars reticulata (SNr), and pedunculopontine tegmental nucleus (PPTg), revealing complex interactions and providing insights into the information transmission mechanisms underlying these circuits.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Cell Biology
Joseph J. Lebowitz, Aditi Banerjee, Claire Qiao, James R. Bunzow, John T. Williams, Pascal S. Kaeser
Summary: In this study, mouse genetics and whole-cell electrophysiology were used to demonstrate that the fast calcium sensor Synaptotagmin-1 (Syt-1) plays a crucial role in somatodendritic dopamine release. Ablation of Syt-1 from dopamine neurons significantly reduced stimulus-evoked D2 receptor-mediated inhibitory postsynaptic currents (D2-IPSCs), while D2-IPSCs evoked by paired stimuli exhibited less depression and high-frequency trains restored dopamine release.
Article
Clinical Neurology
Yong Hu, Thong C. Ma, Stephanie L. Alberico, Yunmin Ding, Lingjing Jin, Un Jung Kang
Summary: This study aimed to determine whether direct modulation of SNr GABAergic neurons and SNr projections to the PPN can regulate PD symptoms and levodopa-induced dyskinesia (LID). The results showed that suppressing SNr neuron activity improved akinesia, while increasing SNr neuronal activity significantly reduced LID. The projections from SNr to PPN likely mediate the antidyskinetic effect of increasing SNr neuronal activity.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Nicole E. Chambers, Michael Coyle, Jordan Sergio, Kathryn Lanza, Carolyn Saito, Brent Topping, Stewart D. Clark, Christopher Bishop
Summary: This study found that cholinergic neurons in the pedunculopontine nucleus (PPN) affect gait parameters related to postural stability, potentially serving as a target for reducing intractable postural instability in patients with Parkinson's disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Rubens Gisbert Cury, Nicola Pavese, Joachim K. Krauss, Elena Moro
Summary: Gait issues in Parkinson's disease are common and disabling, and current therapies have limitations. There is increasing interest in alternative neuromodulation targets and techniques, but challenges remain.
NPJ PARKINSONS DISEASE
(2022)
Article
Chemistry, Analytical
Jordan Holmes, Thorsten Lau, Rachel Saylor, Nadine Fernandez-Novel, Melinda Hersey, Deanna Keen, Lena Hampel, Sandra Horschitz, Julia Ladewig, Brenna Parke, Michael C. Reed, H. Frederik Nijhout, Janet Best, Philipp Koch, Parastoo Hashemi
Summary: Depression is a pressing public health crisis, and better diagnostics and therapeutics are urgently needed. Researchers have developed a chemical model using human-derived stem cells to investigate serotonin neurotransmission, which has the potential to be a translational tool for neuropsychopharmacology.
ANALYTICAL CHEMISTRY
(2022)
Article
Neurosciences
Olga Skiteva, Ning Yao, Ioannis Mantas, Xiaoqun Zhang, Thomas Perlmann, Per Svenningsson, Karima Chergui
Summary: In Parkinson's disease (PD), degeneration of dopaminergic (DA) neurons occurs in the substantia nigra pars compacta (SNc). This study investigated the function of voltage-gated calcium channels (VGCCs) in two different mouse models of PD. The findings revealed opposite changes in the contribution of T-type and L-type VGCCs in DA neuron somata, potentially linked to oxidative stress.
NPJ PARKINSONS DISEASE
(2023)
Article
Multidisciplinary Sciences
Wen-Liang Zhou, Kristen Kim, Farhan Ali, Steven T. Pittenger, Cali A. Calarco, Yann S. Mineur, Charu Ramakrishnan, Karl Deisseroth, Alex C. Kwan, Marina R. Picciotto
Summary: Dopamine signaling from the ventral tegmental area (VTA) is important for reward-related behaviors. This study reveals that neighboring VTA GABAergic neurons project to the ventral pallidum (VP) and their activity correlates with reward size and palatability. Stimulation of this GABA projection enhances the activity of VP neurons involved in seeking reward and improves performance in a cue-reward task.
Article
Behavioral Sciences
Daniel J. Foster, Zoey K. Bryant, P. Jeffrey Conn
Summary: Targeting specific muscarinic acetylcholine receptor subtypes may provide more comprehensive symptomatic relief for schizophrenia patients. Studies show that M1, M4, and M5 receptor subtypes modulate brain circuits and physiology underlying positive, negative, and cognitive symptoms of schizophrenia.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Article
Neurosciences
Christopher W. Tschumi, Harris E. Blankenship, Ramaswamy Sharma, William B. Lynch, Michael J. Beckstead
Summary: In this study, it was discovered that the release of neurotensin by dopamine neurons drives signaling between dopamine neurons. This feedforward mechanism may increase the excitability of dopamine neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Lauren E. McElvain, Yuncong Chen, Jeffrey D. Moore, G. Stefano Brigidi, Brenda L. Bloodgood, Byung Kook Lim, Rui M. Costa, David Kleinfeld
Summary: This study investigates the organization and physiology of projection populations in the substantia nigra pars reticulata (SNr) in mice, revealing subpopulations within SNr that project to functionally distinct brain stem regions. These subpopulations are electrophysiologically specialized and send parallel outputs to specific brain stem targets. Additionally, they also collateralize extensively to common diencephalon targets, demonstrating the complexity of SNr signaling organization.
Article
Clinical Neurology
Ilias Thomas, Moudud Alam, Filip Bergquist, Dongni Johansson, Mevludin Memedi, Dag Nyholm, Jerker Westin
JOURNAL OF NEUROLOGY
(2019)
Article
Clinical Neurology
Dongni Johansson, Ilias Thomas, Anders Ericsson, Anders Johansson, Alexander Medvedev, Mevludin Memedi, Dag Nyholm, Fredrik Ohlsson, Marina Senek, Jack Spira, Jerker Westin, Filip Bergquist
PARKINSONISM & RELATED DISORDERS
(2019)
Article
Endocrinology & Metabolism
Jesper Vestlund, Filip Bergquist, Daniel Eckernas, Valentina Licheri, Louise Adermark, Elisabet Jerlhag
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Neurosciences
Ghazaleh Samoudi, Andrea Nilsson, Thomas Carlsson, Filip Bergquist
Article
Computer Science, Information Systems
Somayeh Aghanavesi, Filip Bergquist, Dag Nyholm, Marina Senek, Mevludin Memedi
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2020)
Article
Multidisciplinary Sciences
Sara Hestehave, Klas S. P. Abelson, Tina Bronnum Pedersen, David P. Finn, Daniel R. Andersson, Gordon Munro
SCIENTIFIC REPORTS
(2020)
Proceedings Paper
Computer Science, Artificial Intelligence
Teodora Matic, Somayeh Aghanavesi, Mevludin Memedi, Dag Nyholm, Filip Bergquist, Vida Groznik, Jure Zabkar, Aleksander Sadikov
ARTIFICIAL INTELLIGENCE IN MEDICINE, AIME 2019
(2019)
Meeting Abstract
Clinical Neurology
P. Svenningsson, P. Odin, N. Dizdar, F. Bergquist, A. Johansson, D. Nyholm, K. Wictorin, J. Tedroff
MOVEMENT DISORDERS
(2019)
Meeting Abstract
Clinical Neurology
F. Bergquist, A. Cvejtkovic, A. C. Sjostrom, S. Wallerstedt
MOVEMENT DISORDERS
(2019)
Meeting Abstract
Clinical Neurology
Peter Lynch, Rajesh Pahwa, Filip Bergquist, Malcolm Horne
Meeting Abstract
Clinical Neurology
Peter Lynch, Rajesh Pahwa, Filip Bergquist, Malcolm Horne
Meeting Abstract
Clinical Neurology
S. Aghanavesi, M. Memedi, M. Senek, D. Nyholm, F. Bergquist
MOVEMENT DISORDERS
(2018)
Meeting Abstract
Clinical Neurology
F. Bergquist, A. Ax, A. Sjostrom, S. Wallerstedt
MOVEMENT DISORDERS
(2018)
Meeting Abstract
Clinical Neurology
P. Lynch, R. Pahwa, F. Bergquist, M. Horne
MOVEMENT DISORDERS
(2018)
Meeting Abstract
Clinical Neurology
M. Memedi, S. Aghanavesi, D. Nyholm, F. Bergquist, M. Senek
MOVEMENT DISORDERS
(2018)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
