Review
Biochemistry & Molecular Biology
Ivona Maria Tudorancea, Mitica Ciorpac, Gabriela Dumitrita Stanciu, Catalin Caratasu, Alina Sacarescu, Bogdan Ignat, Alexandra Burlui, Elena Rezus, Ioana Creanga, Teodora Alexa-Stratulat, Ionut Tudorancea, Bogdan Ionel Tamba
Summary: The endocannabinoid system (ECS) plays a significant role in regulating various aspects of mammalian physiology and has potential therapeutic effects in age-related diseases. This comprehensive review explores the complex interaction between the cannabinoid system (CS) and neurodegenerative, oncological, skeletal, and cardiovascular disorders, highlighting the potential of cannabinoids to ameliorate these conditions. The role of the ECS in improving aging-associated immune system dysregulation is also discussed.
Review
Pharmacology & Pharmacy
Haofuzi Zhang, Xin Li, Dan Liao, Peng Luo, Xiaofan Jiang
Summary: ABHD6 is a transmembrane serine hydrolase that plays important roles in neurotransmission, inflammation, and other biological processes. It has potential therapeutic implications for neurological diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Clinical Neurology
Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Miriam Francavilla, Roberto De Icco, Lara Ahmad, Cristina Tassorelli
Summary: Endocannabinoids and related lipids may reduce trigeminal nociception by interacting with pathways associated with migraine, suggesting a potential synergistic or similar effect. Modulation of the metabolic pathways of the endocannabinoid system (ECS) may serve as the basis for new migraine treatments. There is a need for further research in this area, given the various options and abundance of data already obtained in animal models. Several molecules related to the ECS or allosteric modulation of CB1 receptors have emerged as potential therapeutic targets for migraine-related pain. Accurate biochemical and pharmacological characterization is necessary for any new compounds undergoing testing and development.
Review
Neurosciences
Shuangtao Li, Yuanbing Huang, Lijun Yu, Xiaoyu Ji, Jie Wu
Summary: Cannabinoids, isolated from cannabis and present in animal nervous and immune systems, have shown promising clinical medicinal value, particularly in the field of neurodegenerative diseases such as Alzheimer's disease. This review explores the therapeutic potential of cannabinoids in treating Alzheimer's disease, highlighting their interactions with different endocannabinoid receptor subtypes and the role of the endocannabinoid system in this disease. The underlying mechanisms and potential usefulness of cannabinoids in clinical treatment are also discussed.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Integrative & Complementary Medicine
Shan -Shan Zhang, Niu-Niu Zhang, Lee-Yan Sheen, Nai-Sheng Bai, Tian-Tian Guo, Chi-Tang Ho
Summary: This article provides an overview of natural cannabinoids (phyto-cannabinoids and endocannabinoids) and their pharmacological activities on central nervous system (CNS) diseases. The endocannabinoid system and microglia were found to play a crucial role in the treatment of CNS diseases. Future studies are expected to explore other types of cannabinoids and their mechanisms of pharmacological activities.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Antonietta Santoro, Elena Mele, Marianna Marino, Andrea Viggiano, Stefania Lucia Nori, Rosaria Meccariello
Summary: The article discusses the interaction between the endocannabinoid system and estrogen system at both central and peripheral levels, with a focus on the central nervous system, reproduction, and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Catherine R. Healy, Georgina Gethin, Abhay Pandit, David P. Finn
Summary: Chronic wounds impose a significant burden on individuals and the healthcare system, with pain being the most challenging aspect of living with these wounds. The cutaneous endocannabinoid system shows potential in addressing wound-related pain and inflammation, as well as promoting wound healing. However, more research, including preclinical studies and randomized control trials, is needed to fully explore the therapeutic applications of the endocannabinoid system in chronic wound management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Ruhan Deniz Topuz, Mehmet Zahid Cetinkaya, Dilsat Erumit, Kubra Duvan Aydemir, Ozgur Gunduz, Cetin Hakan Karadag, Ahmet Ulugol
Summary: Dipyrone exhibited antidepressant and anxiolytic effects in mice exposed to chronic unpredictable mild stress, with its anxiolytic effect possibly mediated through CB1 receptors and its antidepressant action possibly mediated through TRPV1 receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daniela Matei, Dan Trofin, Daniel Andrei Iordan, Ilie Onu, Iustina Condurache, Catalin Ionite, Ioana Buculei
Summary: The endocannabinoid system (ECS) plays a role in various physiological processes and can be activated by physical exercise. Endocannabinoids generated during exercise contribute to the phenomenon of a runner's high, which is associated with pain relief, sedation, heightened euphoria, and reduced anxiety levels. This review provides an overview of the current understanding of the relationship between endocannabinoids and physical effort, summarizing relevant studies in the literature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Beth M. Wiese, Angelica Alvarez Reyes, Todd W. Vanderah, Tally M. Largent-Milnes
Summary: Recent changes in cannabis accessibility have led to the need for understanding the interaction between cannabinoids and the endocannabinoid system with other physiological structures. The endocannabinoid system plays a critical role in respiratory homeostasis and pulmonary functionality. This review focuses on the influence of the endocannabinoid system on the central and peripheral respiratory functionality, and discusses the potential therapeutic applications and safety profile expansion of opioids in respiratory diseases.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazare, Sergio Oddi, Mauro Maccarrone
Summary: Chronic exposure to beta-amyloid peptides (A beta) may modify the endocannabinoid signaling in microglial cells, leading to a pro-AD phenotype. A beta-exposed microglia produced more 2-arachidonoylglycerol (2-AG) and showed altered expression of enzymes and receptors involved in 2-AG synthesis and signaling. Enhanced 2-AG signaling may contribute to the pro-AD phenotype of microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Guy Shapira, Ifat Israel-Elgali, Meitar Grad, Eden Avnat, Lital Rachmany, Yosef Sarne, Noam Shomron
Summary: A microdose of THC can improve cognitive function and cause changes in brain morphology and biochemistry in old mice, possibly by affecting gene expression related to neurogenesis and brain development.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Tristyn L. Clarke, Rachael L. Johnson, Jonathan J. Simone, Robert L. Carlone
Summary: This review provides a comprehensive summary of the endocannabinoid system, with a focus on the current advances in the contributions of the endocannabinoid system to invertebrate neurodevelopment and regeneration. It emphasizes the promising results of research investigating the role of cannabinoids in regeneration and neurodevelopment in vertebrate models, while highlighting the importance of invertebrate species as models for regeneration research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Saki Sultana, Geraint Berger, Christian Lehmann
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition with unknown etiology and limited treatment options. Modulating the endogenous cannabinoid system (ECS) has shown benefits in alleviating pain and inflammation associated with IC/BPS.
Article
Biochemistry & Molecular Biology
Prakash Nidadavolu, Andras Bilkei-Gorzo, Felix Effah, Este Leidmaa, Britta Schuermann, Moritz Berger, Laura Bindila, Matthias Schmid, Beat Lutz, Andreas Zimmer, Alexis Bailey
Summary: The study on the eCB system in the mouse brain revealed that middle age is the period when the eCB system is most affected. During this period, substances such as 2-AG and AEA had significantly decreased concentrations in specific brain regions, which may affect the process of cognitive aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Clinical Neurology
A. Del Pozo Sanz, M. Villa, C. Vargas, M. Martinez, L. Silva, A. Gutierrez-Rodriguez, J. Martinez-Orgado
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Pediatrics
Maria Jose Rodriguez, Araceli Corredera, Jose Martinez-Orgado, Luis Arruza
EUROPEAN JOURNAL OF PEDIATRICS
(2020)
Article
Hematology
Cheng Yin Yuan, Vivian Zhou, Garrett Sauber, Todd Stollenwerk, Richard Komorowski, Alicia Lopez, Rosa Maria Tolon, Julian Romero, Cecilia J. Hillard, William R. Drobyski
Summary: The type 2 cannabinoid receptor CB2R plays a critical role in GVHD regulation, with effective therapeutic targeting depending on agonist signaling characteristics and receptor selectivity in conjunction with the composition of pathogenic immune effector cells.
Article
Chemistry, Multidisciplinary
Roman C. Sarott, Matthias Westphal, Patrick Pfaff, Claudia Korn, David A. Sykes, Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Marie Weise, Yelena Mostinski, Pattarin Hompluem, Eline Koers, Tamara Miljus, Nicolas J. Roth, Hermon Asmelash, Man C. Vong, Jacopo Piovesan, Wolfgang Guba, Arne C. Rufer, Eric A. Kusznir, Sylwia Huber, Catarina Raposo, Elisabeth A. Zirwes, Anja Osterwald, Anto Pavlovic, Svenja Moes, Jennifer Beck, Irene Benito-Cuesta, Teresa Grande, Samuel Ruiz de Martin Esteban, Alexei Yeliseev, Faye Drawnel, Gabriella Widmer, Daniela Holzer, Tom van der Wel, Harpreet Mandhair, Cheng-Yin Yuan, William R. Drobyski, Yurii Saroz, Natasha Grimsey, Michael Honer, Juergen Fingerle, Klaus Gawrisch, Julian Romero, Cecilia J. Hillard, Zoltan V. Varga, Mario van der Stelt, Pal Pacher, Juerg Gertsch, Peter J. McCormick, Christoph Ullmer, Sergio Oddi, Mauro Maccarrone, Dmitry B. Veprintsev, Marc Nazare, Uwe Grether, Erick M. Carreira
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Nutrition & Dietetics
Andrea Gila-Diaz, Gloria Herranz Carrillo, Silvia Canas, Miguel Saenz de Pipaon, Jose Antonio Martinez-Orgado, Pilar Rodriguez-Rodriguez, Angel Luis Lopez de Pablo, Maria A. Martin-Cabrejas, David Ramiro-Cortijo, Silvia M. Arribas
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Isabel Miras, Eva Vierge, Macarena Garcia, Luis Arruza, Enrique Criado, Jose Tomas Ramos, Jose Martinez-Orgado
Summary: Congenital cutaneous candidiasis is a rare invasive fungal infection that typically occurs in the first days of life, with classic presentation of extensive erythematous rash. Extremely low birth weight infants are most commonly affected. Early and prolonged treatment has been associated with decreased mortality.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Clinical Neurology
Carmen Rodriguez-Cueto, Marta Gomez-Almeria, Laura Garcia Toscano, Julian Romero, Cecilia J. Hillard, Eva de Lago, Javier Fernandez-Ruiz
Summary: The activation of the cannabinoid receptor type-2 (CB2) has neuroprotective effects in ALS models, while the inactivation of CB2 receptor leads to accelerated deterioration and premature mortality in TDP-43 transgenic mice. Pharmacological inactivation of CB2 receptor also showed subtle trends towards worsening ALS symptoms. These findings suggest the potential of CB2 receptor agonists as a neuroprotective therapy for ALS.
Article
Immunology
Gonzalo Ruiz-Perez, Samuel Ruiz de Martin Esteban, Sharai Marques, Noelia Aparicio, M. Teresa Grande, Irene Benito-Cuesta, Ana M. Martinez-Relimpio, M. Andrea Arnanz, Rosa M. Tolon, Maria Posada-Ayala, Benjamin F. Cravatt, Jose A. Esteban, Julian Romero, Rocio Palenzuela
Summary: The study investigates the cellular and molecular mechanisms associated with improving neurodegeneration in 5xFAD mouse model by modulating the endocannabinoid system. The results demonstrate that increasing endocannabinoid tone rescues hippocampal synaptic plasticity and triggers augmented microglial activation and amyloid beta phagocytosis, leading to reversal of the neuronal phenotype associated with Alzheimer's disease.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Maria Alvarez-Garcia, Isabel Cuellar-Flores, Purificacion Sierra-Garcia, Jose Martinez-Orgado
Summary: In this study, children survivors of NHIE were found to have an increased risk of developing mood disturbances. They scored lower in developmental and socio-emotional status compared to healthy children. This finding highlights the need for further research on the long-term consequences of NHIE in children.
Article
Biochemistry & Molecular Biology
Jaume Lillo, Iu Raich, Laura Silva, David A. Zafra, Alejandro Lillo, Carlos Ferreiro-Vera, Veronica Sanchez de Medina, Jose Martinez-Orgado, Rafael Franco, Gemma Navarro
Summary: The study found that CBD acts on CB2-5HT(1A)-Hets and reduces the abnormal expression of the receptor-receptor complex under hypoxic and ischemic conditions, thereby exerting a therapeutic effect on neonatal hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Aaron Del Pozo, Laura Silva, Angela Romero, Maria De Hoz-Rivera, Maria Villa, Maria Martinez-Vega, Maria Eugenia Prados, Eduardo Munoz, Jose Martinez-Orgado
Summary: In immature rats, betulinic acid hydroxamate (BAH) reduces IVH-induced brain damage and prevents its long-term functional consequences by modulating inflammation, excitotoxicity, and oxidative stress.
Article
Biochemistry & Molecular Biology
Maria Villa, Maria Martinez-Vega, Aaron del Pozo, Itziar Muneta-Arrate, Ana Gomez-Soria, Carolina Muguruza, Maria de Hoz-Rivera, Angela Romero, Laura Silva, Luis F. Callado, Maria Jose Casarejos, Jose Martinez-Orgado
Summary: Newborn rats with neonatal stroke showed depressive-like symptoms and hyperactive behavior in the medium and long term, respectively, which were associated with alterations in the dopamine (DA) system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jose Martinez-Orgado, Maria Martinez-Vega, Laura Silva, Angela Romero, Maria de Hoz-Rivera, Maria Villa, Aaron del Pozo
Summary: Oxidative stress is a critical factor in brain damage, especially in the immature brain. Protein carbonylation, a harmful consequence of oxidative stress, has significant implications for neonatal brain injury. The administration of potent antioxidants, like cannabidiol, can reduce cerebral damage and protect neuronal cells.
Meeting Abstract
Clinical Neurology
I. Gomez Estevez, J. Diaz-Diaz, R. Ginestal Lopez, E. Lopez Valdes, A. Marcos Dolado, N. Perez Perez, J. A. Martinez Orgado, C. Oreja-Guevara
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
