Preliminary evidence of neuronal regeneration in the anoxia tolerant vertebrate brain

Postnatal neurogenesis in response to stroke or ischemia is currently of great medical interest. In this study, we investigated the potential for neurogenesis in an anoxia tolerant vertebrate in response to global ischemia. The results suggest sustained neurogenesis in the turtle that increases after ischemic damage, thus revealing a potential physiological adaptation to repeated anoxia-reoxygenation events. This finding further emphasizes the common vertebrate phenomenon of postnatal neurogenesis, with the capacity for extensive regeneration of neurons apparent in some reptilian species. (c) 2008 Elsevier Inc. All rights reserved.