Article
Plant Sciences
Juanzhen Yang, Yuxi Wei, Tong Zhao, Xiaoqian Li, Xuejian Zhao, Xingnan Ouyang, Lihua Zhou, Xiuqin Zhan, Minyi Qian, Jiaying Wang, Xu Shen
Summary: The study found that magnolol (MG) can improve neurological dysfunctions in diabetic peripheral neuropathy (DPN) mice, promote neurite outgrowth, protect nerve structure, and regulate inflammation and apoptosis processes through multiple pathways. These results reveal the potential of MG as a treatment for DPN and provide further understanding of its mechanism of action.
Article
Biochemistry & Molecular Biology
Mohamad-Reza Aghanoori, Prasoon Agarwal, Evan Gauvin, Raghu S. Nagalingam, Raiza Bonomo, Vinith Yathindranath, Darrell R. Smith, Yan Hai, Samantha Lee, Corinne G. Jolivalt, Nigel A. Calcutt, Meaghan J. Jones, Michael P. Czubryt, Donald W. Miller, Vernon W. Dolinsky, Virginie Mansuy-Aubert, Paul Fernyhough
Summary: Aberrant insulin-like growth factor 1 (IGF-1) signaling may be associated with the development of neurodegenerative disorders, and the role of endogenous IGF-1 in neuroprotection is not well established. In this study, high expression of IGF-1 was found in non-peptidergic neurons and satellite glial cells of dorsal root ganglia, and bidirectional transport of IGF-1 along sensory nerves was observed. However, IGF-1 gene expression was reduced in diabetic rats and mice, and this suppression could contribute to neuropathy. CEBP beta overexpression promoted neurite outgrowth and mitochondrial respiration, both of which were affected by IGF-1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Takashi Maeda, Fumiko Sekiguchi, Kenji Mitani, Ryosuke Yamagata, Maho Tsubota, Shigeru Yoshida, Atsufumi Kawabata
Summary: Irregular axon regeneration or remodeling may contribute to neuropathic pain after peripheral nerve trauma. PGE2, in combination with IBMX, promotes neuritogenesis and neurite outgrowth in mouse DRG neurons, involving the EP4 receptor/PKA/Cav3.2 pathway. Morphine, an MOR agonist, suppresses PGE2-induced neuritogenesis and/or neurite outgrowth, suggesting its potential in preventing neuropathic pain.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Vuong M. Pham, Prashanth Komirishetty, Aparna Areti, Trevor Poitras, Nitish Thakor, Douglas W. Zochodne
Summary: This study suggests that insulin signaling may have additive impacts on neuropathy independent of glycemia and PTEN knockdown. The findings show that insulin can promote survival of neurons and proliferation of Schwann cells. In a chronic mouse model of diabetic polyneuropathy, local PTEN inhibition and insulin injections had synergistic effects on correcting key features of the disease. Overall, this suggests that local PTEN inhibition and insulin can provide beneficial trophic support for sensory neurons and Schwann cells in the treatment of diabetic polyneuropathy without requiring metabolic correction.
Article
Endocrinology & Metabolism
Marc Leal-Julia, Jorge J. Vilches, Andrea Onieva, Sergi Verdes, Angela Sanchez, Miguel Chillon, Xavier Navarro, Assumpcio Bosch
Summary: This study characterized the proteome of neural tissues in a type 2 diabetes mouse model and identified differential protein expression profiles related to reduced glycolytic and TCA cycle metabolism, increased lipid catabolism, dysregulation of muscle-like proteins, altered cytoskeleton-related proteins, activation of inflammatory responses, and changes in glutathione metabolism and oxidative stress. These findings suggest that energy deficiency may play a key role in the neurodegeneration observed in diabetic neuropathy.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Qianqian Chen, Yang Miao, Zhipeng Xu, Ruirui Zhang, Sheng Yi
Summary: Schwann cells play a crucial role in nerve regeneration and are commonly used in tissue engineering. Identifying Schwann cells with enhanced migration ability is important for improving recovery effects. This study compared Schwann cells from different anatomical locations and found that dorsal root ganglia (DRG) Schwann cells have faster migration speed than sciatic nerve (SN) Schwann cells.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Neurosciences
Stephanie A. Eid, Amy E. Rumora, Bogdan Beirowski, David L. Bennett, Junguk Hur, Masha G. Savelieff, Eva L. Feldman
Summary: The prevalence of diabetes is increasing due to the aging population, with type 2 diabetes being the most common type. Diabetic peripheral neuropathy is a complication that damages peripheral nerves and is influenced by metabolic and bioenergetic dysfunction. Recent evidence suggests that obesity and dyslipidemia also contribute to this condition.
Article
Biology
Jinbin Zhai, Hyukmin Kim, Seung Baek Han, Meredith Manire, Rachel Yoo, Shuhuan Pang, George M. Smith, Young-Jin Son
Summary: In mice, eliminating myelin inhibitors and CSPGs together only slightly increased regeneration of conditioned-lesioned DR axons across the DREZ, while their absence significantly enhanced regeneration of GDNF-stimulated axons, emphasizing the importance of elevating intrinsic growth capacity. This suggests that myelin inhibitors and CSPGs are not the primary mechanisms stopping axons at the DREZ.
Article
Cell Biology
Bo Pang, Ling Qiao, Shaoxin Wang, Xin Guo, Yun Xie, Liping Han
Summary: MiR-214-3p alleviated diabetes-induced nerve injury, pathological lesions, cell apoptosis, and inflammation in DRG through regulating Nav1.3 and TLR4 in STZ-induced rats. These findings suggest novel therapeutic targets for clinical treatment of diabetic neuropathy.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Immunology
James M. Nichols, Caitlin Crelli, Lu Liu, Hoang Vu Pham, Jelena M. Janjic, Andrew J. Shepherd
Summary: This study introduces a novel fluorescently labeled perfluorocarbon nanoemulsion for monitoring phagocytic macrophages in diabetic neuropathy. In vitro experiments showed high stability and uptake of the nanoemulsion by macrophages. In vivo tracking revealed distribution to macrophages in tissues, with reduced distribution in Lepr(db/db) mice.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Chemistry, Multidisciplinary
Jia-wen Xu, Xu Xu, Yun Ling, Yan-chun Wang, Yu-jie Huang, Juan-zhen Yang, Jia-ying Wang, Xu Shen
Summary: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes without cure. In this study, the therapeutic potential of vincamine (Vin), a GPR40 agonist, in ameliorating DPN-like pathology was evaluated in diabetic mice. The results showed that Vin administration improved neurological dysfunctions, blood flow velocities, blood perfusion areas, myelin sheath injury, and intraepidermal nerve fiber density impairment in DPN mice, suggesting that pharmacological activation of GPR40 could be a promising therapeutic strategy for DPN.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Onur Avci, Ercan Ozdemir, Ahmet Sevki Taskiran, Zeynep Deniz Sahin Inan, Sinan Gursoy
Summary: The study found that metformin can alleviate the tolerance to morphine in diabetic rats and exhibit anti-apoptotic activity in DRG neurons.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Neurosciences
Maricris Bautista, George S. Katselis, Bari Chowdhury, Paulos Chumala, Ruhi Mahendra, Priyansh Desai, Justi Hall, Subha Kalyaanamoorthy, Anand Krishnan
Summary: Injuries to peripheral nerves are common, but there are no effective drug therapies available for nerve repair. The slow growth rate of axons and limited access to growth factors hinder natural nerve repair. Understanding the molecules that can promote axon growth may lead to therapeutic opportunities.
Article
Biochemistry & Molecular Biology
Pengfei Yuan, Fuhu Song, Pian Zhu, Keke Fan, Qinming Liao, Lijin Huang, Zhongjie Liu
Summary: This study reveals the regulatory role of PARP1 in the progression of painful diabetic neuropathy (PDN) through impairment of mitophagy. Inhibition of PARP1 and restoration of mitophagy function are potential therapeutic targets for PDN.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Anesthesiology
Dale George, Sandra Hackelberg, Nirupa Jayaraj, Dongjun Ren, Seby Edaserry, Craig Rathwell, Rachel Miller, Jeffery Savas, Richard Miller, Daniela Maria Menichella, Anne-Marie Malfait
Summary: This research identified elevated mitochondrial fission proteins and increased calcium signaling in dorsal root ganglion (DRG) neurons in a mouse model of painful diabetic neuropathy (PDN). By selectively deleting the mitochondrial calcium uniporter, the study demonstrated the restoration of normal mitochondrial morphology, prevention of axonal degeneration, and reversal of mechanical allodynia in the PDN mouse model. These findings indicate the potential of targeting calcium entry into nociceptor mitochondria as an effective therapeutic approach for PDN.
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
