Article
Cell Biology
Qiudong Yang, Wenhua Zhao, Yuyi Chen, Yue Chen, Jiali Shi, Ran Qin, Hua Wang, Ruixia Wang, Hua Yuan, Wen Sun
Summary: The study reveals that the RelA/miR-30a/NLRP3 signaling axis is involved in rheumatoid arthritis by regulating the NLRP3 inflammasome in macrophages.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Xueting Wang, Linlin Huang, Shan Jiang, Kang Cheng, Dan Wang, Qianqian Luo, Xiaomei Wu, Li Zhu
Summary: Testosterone deficiency is common in male COPD patients and may worsen the disease. Testosterone replacement therapy has been shown to slow COPD progression by inhibiting NRF1-derived NF-kappa B signaling and phosphorylation of p65 in pulmonary epithelial inflammation.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tingting Yuan, Honglin Tang, Xiaojie Xu, Jingjing Shao, Gaojun Wu, Young-Chang Cho, Yuan Ping, Guang Liang
Summary: This study developed an inflammation-inducible CRISPR-Cas9 system by grafting a sequence that binds with NF-KB to the CRISPR-Cas9 framework, named NBS-CRISPR. By targeting the MyD88 gene, a crucial player in the NF-KB signaling pathway, this system successfully reversed inflammatory conditions and achieved impressive therapeutic effects.
Article
Immunology
Xiaohe Li, Qing Liang, Shaoyan Gao, Qiuyan Jiang, Fangxia Zhang, Ruiqin Zhang, Hao Ruan, Shuangling Li, Jiaoyan Luan, Ruxia Deng, Honggang Zhou, Hui Huang, Cheng Yang
Summary: Lenalidomide has potential anti-fibrotic effects by suppressing inflammation-related signaling pathways, thereby reducing pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Respiratory System
Sven Schneider, Irmgard Merfort, Marco Idzko, Andreas Zech
Summary: Research has found that the P2X4 signaling pathway is upregulated in patients with chronic obstructive pulmonary disease (COPD) and mice exposed to cigarette smoke. Blocking P2X4 signaling can alleviate cigarette smoke-induced airway inflammation and lung parenchymal damage. Inhibiting P2X4 in human macrophages can reduce the release of proinflammatory cytokines in response to cigarette smoke extract stimulation.
RESPIRATORY RESEARCH
(2022)
Article
Oncology
Harald Krenzlin, Mykola Zdioruk, Michal O. Nowicki, Tomer Finkelberg, Naureen Keric, Niels Lemmermann, Magdalena Skubal, E. Antonio Chiocca, Charles H. Cook, Sean E. Lawler
Summary: The study suggests that the CMV-induced upregulation of c-MET may be a potential mechanism involved in the effects of CMV on GBM growth.
Article
Cell Biology
Anni Hu, Fan Xiao, Wenjing Wu, Huilin Xu, Jiansheng Su
Summary: This study investigates the effects of lincRNA-EPS on periodontal inflammation mediated by inflammasomes and reveals that lincRNA-EPS can alleviate periodontitis by suppressing the activation of the NF-kappa B signaling pathway through interacting with TDP43.
CELL PROLIFERATION
(2023)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Biochemistry & Molecular Biology
Matthias Kist, Laszlo G. Komuves, Tatiana Goncharov, Debra L. Dugger, Charles Yu, Merone Roose-Girma, Kim Newton, Joshua D. Webster, Domagoj Vucic
Summary: Mutating the ubiquitination site K376 of RIPK1 in mice activates cell death, leading to embryonic lethality, while mutation at K115 has minimal impact on cell death. Embryonic lethality can be prevented by loss of TNFR1 or simultaneous deletion of Caspase-8 and RIPK3 genes. Elimination of the K376 ubiquitination site in adult mice is tolerated but results in sensitivity to TNF-induced lethality.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Esha Singla, Gayatri Puri, Vivek Dharwal, Amarjit S. Naura
Summary: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease that can be effectively modulated by timely administration of Gallic acid (GA), which can reduce inflammation and restore redox balance in the lungs, thereby alleviating exacerbation manifestations of COPD.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Simin Rahighi, Mamta Iyer, Hamid Oveisi, Sammy Nasser, Vincent Duong
Summary: The NZF1 domain of the HOIP subunit of LUBAC binds to the NEMO substrate and recruits the catalytic domains, leading to site-specific ubiquitination of NEMO.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Ying Jin, Yao Liu, Lei Xu, Jie Xu, Yulian Xiong, Yazhi Peng, Ke Ding, Shuang Zheng, Nan Yang, Zemei Zhang, Lin Li, Liguo Tan, HongXian Song, Jian Fu
Summary: This study provides mechanistic insights into the assembly and activation of NLRP3 inflammasome and its role in atherosclerosis. It demonstrates the importance of NLRP3 inflammasome in regulating mitochondrial function and suggests that inhibiting the assembly and activation of NLRP3 inflammasome can effectively mitigate atherosclerosis.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Hisatake Matsumoto, Brendon P. Scicluna, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gurkan, Erik Malmstrom, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van 't Veer, Tom van der Poll
Summary: The study indicates that HIVEP1 acts as a negative regulator of NF-κB in monocytes, inhibiting the proinflammatory response induced by bacterial agonists. Dysregulation of HIVEP1 leads to significant changes in the monocyte transcriptome and modulation of NF-κB responsive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Fengen Liu, Binhui Xie, Rong Ye, Yuankang Xie, Baiyin Zhong, Jinrong Zhu, Yao Tang, Zelong Lin, Huiru Tang, Ziqing Wu, Heping Li
Summary: In this study, it was found that overexpression of TRIM47 is associated with tumor progression and poor prognosis in triple-negative breast cancer. The researchers demonstrated that TRIM47 directly interacts with BRCA1 and induces proteasome turnover of BRCA1, leading to a decrease in BRCA1 protein levels in TNBC. Additionally, TRIM47 overexpression confers sensitivity to the PARP inhibitor olaparib, while TRIM47 inhibition confers resistance to olaparib in TNBC. Overexpression of BRCA1 also increases resistance to olaparib in TRIM47-overexpression-induced PARP inhibition sensitivity. These findings suggest that targeting the TRIM47/BRCA1 axis may be a promising prognostic factor and therapeutic target for TNBC.
Article
Respiratory System
Ratoe Suraya, Tatsuya Nagano, Gusty Rizky Teguh Ryanto, Wiwin Is Effendi, Daisuke Hazama, Naoko Katsurada, Masatsugu Yamamoto, Motoko Tachihara, Noriaki Emoto, Yoshihiro Nishimura, Kazuyuki Kobayashi
Summary: This study investigated the effects of BGF triple therapy on COPD and COPD-PH using a mouse model. The results demonstrated that BGF treatment could reduce inflammation, improve emphysematous lung structure and hypoxemia, and prevent the development of COPD-PH.
RESPIRATORY RESEARCH
(2022)