Article
Cell Biology
Mounica Bandela, Eleftheria Letsiou, Viswanathan Natarajan, Lorraine B. Ware, Joe G. N. Garcia, Sunit Singla, Steven M. Dudek
Summary: The study suggests that cigarette smoke or e-cigarette vapor-induced apoptosis in lung endothelial cells is related to the protein Cortactin (CTTN), with reduced levels of CTTN potentially increasing the risk of vascular damage and exacerbating the development of COPD.
Article
Ophthalmology
Muhammad Ali, Shahid Y. Khan, Yura Jang, Chan Hyun Na, C. Conover Talbot, John D. Gottsch, James T. Handa, S. Amer Riazuddin
Summary: This study found that exposure to chronic cigarette smoke led to a decrease in corneal endothelial cell density in mice, accompanied by reduced levels of multiple collagen and extracellular matrix proteins associated with Descemet's membrane.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Integrative & Complementary Medicine
Kenta Murata, Nina Fujita, Ryuji Takahashi
Summary: This study found that NYT can alleviate cigarette smoke-induced cell injury and inflammation by inhibiting the JNK signaling pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Multidisciplinary Sciences
Ryan H. Nguyen, Laura B. Vater, Lava R. Timsina, Gregory A. Durm, Katelin Rupp, Keylee Wright, Miranda H. Spitznagle, Brandy Paul, Shadia Jalal, Lisa Carter-Harris, Karen S. Hudmon, Nasser H. Hanna, Patrick J. Loehrer, DuyKhanh P. Ceppa
Summary: The study found that counties with stronger smoke-free air ordinances had lower smoking rates and fewer new lung cancer cases per year. Therefore, strengthening smoke-free air ordinances is crucial for reducing lung cancer incidence.
Article
Medicine, Research & Experimental
Tingting Wu, Keye Xu, Chaobo Liu, Yan Li, Mingcai Li
Summary: This study aimed to investigate the effect of interleukin-37 (IL-37) on cigarette smoke-induced lung inflammation. By administering IL-37-expressing lentivirus to mice, it was found that IL-37 can alleviate weight loss and pulmonary inflammation induced by cigarette smoke. IL-37 also significantly inhibited inflammatory cell recruitment, reduced inflammatory cell increase, and suppressed the production of pro-inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Physiology
Marta Schiliro, Elizabeth R. Vogel, Lucia Paolini, Christina M. Pabelick
Summary: The detrimental effects of tobacco exposure on children's health are well known, and the prevalence of secondhand or direct cigarette smoke exposure in the pediatric population has not significantly decreased over time. Additionally, the rapid increase in e-cigarette use among adolescents has raised public health concerns.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Tiantian Cen, Yifeng Mai, Jie Jin, Minxuan Huang, Mingcai Li, Shanshan Wang, Hongying Ma
Summary: Our study aimed to investigate the ability of IL-41 to protect against CS-induced lung inflammation in vivo. The results showed that IL-41 pre-treatment alleviated pulmonary inflammatory infiltration and lung tissue lesions, limited CS-induced weight loss, and promoted the polarization of M2 macrophages. IL-41 also increased the levels of IL-10 and reduced the production of TNF-α, IL-6, and IL-1β.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Respiratory System
Tina Bormann, Regina Maus, Jennifer Stolper, Meritxell Tort Tarres, Christina Brandenberger, Dirk Wedekind, Danny Jonigk, Tobias Welte, Jack Gauldie, Martin Kolb, Ulrich A. Maus
Summary: This study investigates the roles of MMP-2 and MMP-9 in experimental lung fibrosis in mice. Results show that MMP-2 and MMP-9 levels are increased in IPF lung tissue and in mice exposed to adenoviral TGF-beta 1. However, the deletion of MMP-2 or MMP-9, or both, does not have any effect on experimental lung fibrosis.
RESPIRATORY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Kurt Brassington, Stanley M. H. Chan, Huei Jiunn Seow, Aleksandar Dobric, Steven Bozinovski, Stavros Selemidis, Ross Vlahos
Summary: Cigarette smoke exposure impairs vascular function and exacerbates lung inflammation in mice, but these effects can be alleviated by the antioxidant compound ebselen. By reducing oxidative stress and preserving eNOS expression, ebselen effectively reverses aortic endothelial dysfunction caused by CS exposure in mice.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Siddhi Jain, Sneha Durugkar, Pritam Saha, Sharad B. Gokhale, V. G. M. Naidu, Pawan Sharma
Summary: This study examined the efficacy of azithromycin alone and in combination with dexamethasone in treating cigarette smoke-induced acute lung inflammation. The results showed that azithromycin inhibited airway fibrosis, inflammation, and cell toxicity caused by cigarette smoke, and improved lung function. Further research is needed to validate the therapeutic efficacy of azithromycin as a treatment for COPD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carmen A. Ochoa, Claire G. Nissen, Deanna D. Mosley, Christopher D. Bauer, Destiny L. Jordan, Kristina L. Bailey, Todd A. Wyatt
Summary: Most individuals with alcohol use disorders also smoke cigarettes. Exposure to cigarette smoke and alcohol can cause lung injury, but aldehyde-trapping compounds like ADX-102 may offer protection against this damage.
Article
Medicine, Research & Experimental
Jun Liu, Szu-Jung Chen, Ssu-Wei Hsu, Jun Zhang, Ji-Min Li, David C. Yang, Shenwen Gu, Kent E. Pinkerton, Ching-Hsien Chen
Summary: The study found that MARCKS was activated in response to cigarette smoke in human lung cancer cells, specimens, and non-human primate airway epithelium. By investigating its interaction with NF-kappa B-activating protein (NKAP), it revealed MARCKS as a novel NF-kappa B activator in smoke-mediated lung cancer progression.
Article
Immunology
Xiangming Liu, Yiming Ma, Lijuan Luo, Zihang Zeng, Dandan Zong, Yan Chen
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation and lung parenchymal cell apoptosis, with cigarette smoke being the major risk factor. In this study, taxifolin (TAX) was found to significantly alleviate cigarette smoke-induced inflammation and apoptosis in vivo and in vitro. TAX treatment suppressed the elevated levels of IL-1 beta, IL-6, and TNF-alpha, and decreased the ratios of p-i kappa B to i kappa B and p-p65 to p65. Additionally, TAX exhibited antiapoptotic effects by reversing the changes in Bax, CCP3, and Bcl-2 levels induced by cigarette smoke. These findings highlight the potential of TAX in improving COPD pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sneha Kumari, Rashmi Singh
Summary: Curcumin has protective effects on silica-induced airway inflammation and structural changes in the lungs, making it a potential alternative medication for silicosis.
Article
Biochemistry & Molecular Biology
Sneha Kumari, Rashmi Singh
Summary: The study demonstrated the protective effects of intranasal curcumin on silica-induced lung damage in a mouse model of silicosis, reducing airway inflammation, collagen deposition, and fibrosis markers. Curcumin showed better inhibitory effects compared to dexamethasone in protecting lung structure alterations. Additionally, abnormal mitochondria observed in silicosis were reduced in groups treated with curcumin and dexamethasone.
Review
Respiratory System
Edvardas Bagdonas, Jovile Raudoniute, Ieva Bruzauskaite, Ruta Aldonyte
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2015)
Article
Biotechnology & Applied Microbiology
Ieva Bruzauskaite, Jovile Raudoniute, Jaroslav Denkovskij, Edvardas Bagdonas, Sandra Meidute-Abaraviciene, Vaida Simonyte, Daiva Bironaite, Almantas Siaurys, Eiva Bernotiene, Ruta Aldonyte
Article
Respiratory System
Ruta Aldonyte, Edgar Tarun Hutchinson, Bilian Jin, Mark Brantly, Edward Block, Jawaharlal Patel, Jianliang Zhang
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2008)
Article
Environmental Sciences
Jovile Raudoniute, Inga Stasiulaitiene, Ieva Kulvinskiene, Edvardas Bagdonas, Andrius Garbaras, Edvinas Krugly, Dainius Martuzevicius, Daiva Bironaite, Ruta Aldonyte
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Akvile Jarmalaviciute, Virginijus Tunaitis, Egle Strainiene, Ruta Aldonyte, Arunas Ramanavicius, Algirdas Venalis, Karl-Eric Magnusson, Augustas Pivoriunas
JOURNAL OF MOLECULAR NEUROSCIENCE
(2013)
Article
Cell & Tissue Engineering
Virginijus Tunaitis, Veronika Borutinskaite, Ruta Navakauskiene, Grazina Treigyte, Ausra Unguryte, Ruta Aldonyte, Karl-Eric Magnusson, Augustas Pivoriunas
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2011)
Article
Cell & Tissue Engineering
Ruta Aldonyte, Virginijus Tunaitis, Andrejus Surovas, Kristina Suriakaite, Akvile Jarmalaviciute, Karl-Eric Magnusson, Augustas Pivoriunas
REGENERATIVE MEDICINE
(2010)
Article
Cell & Tissue Engineering
Augustas Pivoriunas, Andrejus Surovas, Veronika Borutinskaite, Dalius Matuzevicius, Grazina Treigyte, Jurate Savickiene, Virginijus Tunaitis, Ruta Aldonyte, Akvile Jarmalaviciute, Kristina Suriakaite, Evaldas Liutkevicius, Algirdas Venalis, Dalius Navakauskas, Ruta Navakauskiene, Karl-Eric Magnusson
STEM CELLS AND DEVELOPMENT
(2010)
Article
Pharmacology & Pharmacy
Ieva Kulvinskiene, Jovile Raudoniute, Edvardas Bagdonas, Darius Ciuzas, Karina Poliakovaite, Inga Stasiulaitiene, Danguole Zabulyte, Daiva Bironaite, Petras Rimantas Venskutonis, Dainius Martuzevicius, Ruta Aldonyte
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Rokas Miksiunas, Ruta Aldonyte, Agne Vailionyte, Tadas Jelinskas, Romuald Eimont, Gintare Stankeviciene, Vytautas Cepla, Ramunas Valiokas, Kestutis Rucinskas, Vilius Janusauskas, Siegfried Labeit, Daiva Bironaite
Summary: Dilated cardiomyopathy (DCM) is a common type of heart disease characterized by ventricular dilation and impaired contraction. Research has shown that human mesenchymal stem/stromal cells (hmMSCs) from DCM patients can be induced to differentiate towards cardiac muscle direction with the use of HDAC inhibitor SAHA, potentially offering therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Laurita Klimkaite, Tomas Liveikis, Greta Kaspute, Julija Armalyte, Ruta Aldonyte
Summary: The microbiome, consisting of bacteria, viruses and fungi, in the human body is crucial for human health. Air pollution affects the airway microbiome, leading to potential health issues. Improving air quality is important for promoting healthy microbiomes and general human health.
FUTURE MICROBIOLOGY
(2023)
Article
Cell Biology
R Aldonyte, L Jansson, O Ljungberg, S Larsson, S Janciauskiene
Article
Cell Biology
R Aldonyte, L Jansson, S Janciauskiene
Article
Respiratory System
R Aldonyte, L Jansson, E Piitulainen, S Janciauskiene
RESPIRATORY RESEARCH
(2003)