Article
Immunology
Shijie Li, Shijie Wang, Eric Fordjour, Yaoji Liang, Xuelian Wang, Yonghao Ye, Zhonghu Bai, Yankun Yang, Yongqi Chen
Summary: This study successfully developed a pharmaceutical antibody for inhalation drug delivery targeting eosinophilic asthma. The antibody can block the binding of interleukin-5 to its receptor, inhibiting the proliferation and activation of eosinophils.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Oliver William Massey, Cenk Suphioglu
Summary: IL-5 is a crucial cytokine in the development of asthma, and targeting it with therapeutics can provide effective treatment options. This review discusses the IL-5 pathway and the clinical trial history of IL-5 inhibitors, as well as novel therapeutic strategies involving monoclonal antibodies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Allison J. Burbank, Stephen A. Schworer, Amika Sood, Martha Almond, Kelly Chason, Nathan Bean, Haibo Zhou, Michelle L. Hernandez
Summary: This study found a positive association between airway IL-1 beta concentration and biomarkers of T2 inflammation in acute allergen-induced asthma exacerbation in humans. The results suggest that IL-1 beta plays a role in the pathophysiology of allergic asthma and further study on its role in human asthma is warranted.
RESPIRATORY RESEARCH
(2021)
Editorial Material
Immunology
Ursula Smole, Hamida Hammad
Summary: This study reveals the importance of type 2 immunity in driving the accumulation of ILC2 in inflamed tissues, allowing for balanced responses during inflammation.
Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Immunology
Magdalena Kowalewicz-Kulbat, Piotr Szpakowski, Krzysztof T. Krawczyk, Marek L. Kowalski, Slawomir Kosinski, Franck Biet, Wieslawa Rudnicka, Camille Locht
Summary: The Bacillus Calmette-Guerin (BCG) vaccine, along with recombinant BCG strains producing IL-18, have been shown to potentially protect against unrelated diseases like allergic asthma. Studies have demonstrated that these vaccines can induce the maturation of dendritic cells and decrease exaggerated Th2 responses in allergic asthma patients.
Article
Medicine, Research & Experimental
Hiroshi Handa, Hajime Tsuruoka, Kohei Kinoshita, Masamichi Mineshita
Summary: Recently, several biologics have been approved for the treatment of severe asthma. One of these biologics, dupilumab, is a monoclonal antibody targeting interleukin-4 and interleukin-13. In a specific case, dupilumab was found to be more effective compared to omalizumab and mepolizumab in a patient suspected of having inhaled corticosteroid-induced glucocorticoid hypersensitivity. Therefore, considering a switch to another suitable biologic agent is recommended when one proves ineffective.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hairong Shu, Yong Li, Hangyu Xu, Qing Yin, Jianxin Song, Minqiao Zheng, He Li
Summary: The study found that levels of IFN-related genes were higher in asthma patients, suggesting their potential as biomarkers for early diagnosis.
BIOSCIENCE REPORTS
(2021)
Article
Respiratory System
Laura Mattei, Carey M. Suehs, Khuder Alagha, Arnaud Bourdin, Christophe Brousse, Jeremy Charriot, Gilles Devouassoux, Stephanie Fry, Laurent Guilleminault, Marion Gouitaa, Camille Taille, Pascal Chanez, Laurie Pahus
Summary: This study achieved an expert consensus in defining failure criteria for anti-interleukin 5/R treatment in severe asthma patients. The study proposed objective criteria for treatment failure and provided guidelines for prescription, evaluation, and discontinuation decision-making. These criteria and guidelines can help physicians tailor treatment plans more effectively for severe asthma patients.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2021)
Article
Immunology
Ana Karen Penafiel Vicuna, Marco Yamazaki Nakashimada, Ximena Leon Lara, Elizabeth Mendieta Flores, Maria Enriqueta Nunez Nunez, Juan Carlos Lona-Reyes, Leticia Hernandez Nieto, Maria Guadalupe Ramirez Vazquez, Joel Barroso Santos, Alvaro Lopez Iniguez, Yolanda Gonzalez, Martha Torres, Jose Luis Lezana Fernandez, Carla M. Roman Montes, Edgar Alejandro Medina-Torres, Edith Gonzalez Serrano, Juan Carlos Bustamante Ogando, Saul Lugo Reyes, Oscar Zavaleta Martinez, Aide Tamara Staines Boone, Edna Venegas Montoya, Nancy Evelyn Aguilar Gomez, Camille Soudee, Emmanuelle Jouanguy, Anne Puel, Stephanie Boisson-Dupuis, Sigifredo Pedraza Sanchez, Jean-Laurent Casanova, Francisco Espinosa Rosales, Sara Espinosa Padilla, Jacinta Bustamante, Lizbeth Blancas Galicia
Summary: This study reviewed the clinical, immunological, and genetic characteristics of MSMD patients in Mexico and identified IL12RB1 gene defect as the main cause of MSMD in the cohort. BCG infection was found to be the primary cause of morbidity and mortality in these patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Mohamed Hamed Abdelaziz, Xiaoyun Ji, Jie Wan, Fatma A. Abouelnazar, Sayed F. Abdelwahab, Huaxi Xu
Summary: This article discusses the correlation between allergic asthma and natural infections, exploring effective methods for preventing allergic asthma through natural infections. The authors mentioned the impact of Mycobacterium tuberculosis and helminth infections on the development of allergic asthma, as well as possible pathways for preventing allergic asthma through vaccine design.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Paulina Krzysica, Loes Verhoog, Sonja de Vries, Coen Smits, Huub F. J. Savelkoul, Edwin Tijhaar
Summary: Cytokines are small proteins involved in immune cell communication. Detection of cytokines at the protein level is limited in poultry research. This study develops capture ELISAs for quantifying chicken cytokine proteins, with optimized protocols that show high sensitivity and reliability. These capture ELISAs have wide applicability in immunological research for poultry.
Article
Biochemistry & Molecular Biology
Daisuke Fuji, Takehiro Ando, Masashi Sato, Santhana Vedi, Yukio Takamori, Takumi Yokoyama, Mizuki Yamamoto, Takashi Kawakami
Summary: In this study, directed evolution was performed on human IL-5 using SELEX to discover novel IL-5-binding unnatural cyclic peptides. These peptides can be utilized in various research, therapeutic, and diagnostic applications involving IL-5 signaling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Physiology
Peter Kunc, Jaroslav Fabry, Marian Grendar, Peter Ferenc, Tomas Strachan, Katarina Istvankova, Tatiana Hurtova, Renata Pecova
Summary: This study investigated the association between selected inflammatory biomarkers and cough reflex sensitivity in children with mild and moderate well-controlled type 2 asthma. The results showed a significant association between cough reflex sensitivity and interleukin 113 serum concentrations in the asthmatic group. These findings suggest that interleukin 113 may serve as a potential inflammatory biomarker in clinical practice for children with asthma.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang, Jianxiong Liu
Summary: The study developed a new immunological method using IFN-gamma and IL-2 combinations to differentiate active TB from other pulmonary diseases, showing potential for accurate diagnosis. The sensitivity of series combination test was higher, while the specificity of parallel combination of IFN-gamma /IL-2 was increased. The diagnostic accuracy of series combination correlated with disease severity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)