Article
Biochemistry & Molecular Biology
Su Woong Jung, Su-Mi Kim, Arum Kim, Seon Hwa Park, Ju-Young Moon, Sang-Ho Lee
Summary: The midbody plays a crucial role in the transition of fibroblasts into myofibroblasts by mediating TGF-beta/Smad signaling. The pathway related to microtubules is implicated in kidney fibrosis, and blocking microtubule dynamics can improve kidney fibrosis.
Article
Pharmacology & Pharmacy
Hongchao Jiang, Yaxue Zhao, Huirong Tang, Shixin Duan, Mengkai Li, Xinyi Yang, Jingting Liu, Xinyi Lou, Yuanyuan Cai, Wenjuan Zhao, Lei Sun, Feng Qian
Summary: DSF inhibits pulmonary fibrosis by targeting TGF-beta/SMAD signaling pathway, making it a promising therapeutic candidate for idiopathic pulmonary fibrosis (IPF).
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Antonio Tejera-Munoz, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Sandra Rayego-Mateos, Macarena Orejudo, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Raul R. Rodrigues-Diez
Summary: CCN2 plays a role in both fibrotic responses and growth factor-induced oxidative and proinflammatory responses. Its coexistence with TGF-β is necessary for persistent fibrotic response, but the mechanisms involved are not fully understood. CCN2 increases T beta RII expression in VSMCs and maintains TGF-β pathway activation through an EGFR-SMAD dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Sarah S. McCarthy, Michele Karolak, Leif Oxburgh
Summary: Expansion of interstitial cells in adult kidney is a hallmark of chronic disease, while their proliferation during fetal development is necessary for organ formation. Inactivation of TGF beta/Smad response in mouse interstitial cell lineage leads to overproliferation of interstitial cells regionally in the kidney medulla. Smad4 loss primarily reduces TGF beta signaling in the interstitium, while increasing Wnt/beta-catenin signaling.
Article
Immunology
Renquan Zhang, Hui Liang, Gaoli Liu, Wanli Jiang, Zheng Tang, Qinglu Fan, Zhihao Nie, Haifeng Hu, Ganjun Kang, Songping Xie
Summary: This study found that Nesfatin-1 has significant protective effects against pulmonary fibrosis by blocking the TGF-beta 1/Smad pathway in an AMPKa-dependent manner.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jin-xing Zhu, Wang Ling, Chao Xue, Zhen Zhou, Yi-shuai Zhang, Chen Yan, Mei-ping Wu
Summary: The study aimed to investigate the impact of Higenamine (HG) on chronic cardiac remodeling, particularly cardiac fibrosis. The results showed that HG could alleviate chronic cardiac hypertrophy, fibrosis, and dysfunction by suppressing TGF-β1/Smad signaling and the activation of cardiac fibroblasts (CFs).
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Orthopedics
Nathalie G. M. Thielen, Arjan P. M. van Caam, Henk M. V. Beuningen, Elly L. Vitters, Martijn H. J. van den Bosch, Marije I. Koenders, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan
Summary: The study aimed to block TGF-beta-induced SMAD1/5/9 signaling in primary human OA chondrocytes while maintaining functional SMAD2/3 signaling. The results demonstrated that using a low dose of SB-505124 inhibited SMAD1/5/9 phosphorylation and the expression of ID1 and ID3, while maintaining SMAD2/3 phosphorylation and the induction of JUNB and SERPINE1. In addition, TGF-beta regulated hypertrophic and dedifferentiation markers in OA chondrocytes, and blocking only the SMAD1/5/9 pathway showed stronger inhibition on TGF-beta-induced RUNX2 compared to blocking both SMAD pathways.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Cell Biology
Lih-Fhung Hiew, Chi-Him Poon, Heng-Ze You, Lee-Wei Lim
Summary: Research on TGF-beta/Smad signaling has shown its significance in neurogenesis and its potential impact on neuropsychiatric disorders. The relationship between TGF-beta/Smad signaling and neurogenesis in response to stressors suggests a role in stress response regulation and behavioral outcomes of mood disorders. Modifications to these signaling pathways have been found to have diverse effects on neurogenesis, highlighting the complexity of the interactions involved.
Article
Oncology
Justin Joseph, Capucine R. Magaut, Simon Storevik, Luiz H. Geraldo, Thomas Mathivet, Md Abdul Latif, Justine Rudewicz, Joris Guyon, Matteo Gambaretti, Frida Haukas, Amalie Trones, Lars A. Romo Ystaas, Jubayer A. Hossain, Sandra Ninzima, Sylvain Cuvellier, Wenjing Zhou, Tushar Tomar, Barbara Klink, Lalit Rane, Bronwyn K. Irving, Joanne Marrison, Peter O'Toole, Heiko Wurdak, Jian Wang, Zhang Di, Even Birkeland, Frode S. Berven, Frank Winkler, Frank A. E. Kruyt, Andreas Bikfalvi, Rolf Bjerkvig, Thomas Daubon, Hrvoje Miletic
Summary: Analysis of TCGA data revealed a high activation of the TGF-beta pathway in GBMs compared to oligodendroglial tumors. Stimulation of GBM cell lines with TGF-beta 1 enhanced MT formation and communication via calcium signaling, while inhibition of the TGF-beta pathway significantly reduced MT formation and invasion. Downstream of TGF-beta, thrombospondin 1 (TSP1) was identified as a potential mediator of MT formation in GBM, which was upregulated upon TGF-beta stimulation and inhibited MT formation when knocked down in vitro and in vivo.
Article
Medicine, Research & Experimental
Alex Boye
Summary: Early detection of cancer is crucial for cancer management and limited survival. Understanding cancer biology and key factors in cancer progression plays a significant role in cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Naohiro Nakamura, Katsunori Yoshida, Rinako Tsuda, Miki Murata, Takashi Yamaguchi, Kanehiko Suwa, Mayuko Ichimura, Koichi Tsuneyama, Koichi Matsuzaki, Toshiaki Nakano, Junko Hirohara, Toshihito Seki, Kazuichi Okazaki, M. Eric Gershwin, Makoto Naganuma
Summary: Patients with primary biliary cholangitis (PBC) are at higher risk for developing hepatocellular carcinoma (HCC), especially in the presence of comorbidities like excessive alcohol consumption. This study found that the balance of Smad signals may serve as a biomarker to predict the likelihood of HCC occurrence in PBC patients. Shifting favorably Smad phospho-isoforms through therapies could potentially reduce the risk of PBC-related HCC development.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Cardiac & Cardiovascular Systems
Bijun Chen, Ruoshui Li, Silvia C. Hernandez, Anis Hanna, Kai Su, Arti V. Shinde, Nikolaos G. Frangogiannis
Summary: TGF-beta signaling through Smad2/3 regulates macrophage responses in myocardial infarction. Smad3 plays a crucial role in mediating the anti-inflammatory and phagocytic effects of TGF-beta, while the activation of Smad2 does not affect these processes. Smad3, but not Smad2, is the main mediator of transcriptional effects of TGF-beta on macrophages.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Kang Rong, Tian Wen, Cao Wei, Sun Yang, Zhang Hui-Nan, Feng Ying-Da, Li Chen, Li Ze-Zhi, Li Xiao-Qiang
Summary: LF delays liver fibrosis formation, decreases AST, ALT activities, and increases Alb activity in serum. It reduces oxidative damage, suppresses the TGF-beta/Smad signaling pathway, and plays a role in attenuating CCl4-induced liver fibrosis.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Review
Medicine, General & Internal
Piotr K. Zakrzewski
Summary: Endometrial cancer is a major gynecological cancer among women in their menopausal and postmenopausal age, and the canonical TGF beta pathway plays a crucial role in its development and progression. The TGF beta cascade can act as both a tumor suppressor and tumor promoter, with its effects on endometrial cancer cells depending on the cancer disease stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Shuai Yuan, Dong Guo, Xinzhi Liang, Luhui Zhang, Qun Zhang, Denghui Xie
Summary: This review confirms the protective effect of Relaxin (RLX) in fibrotic ligament diseases (FLDs) and summarizes its mechanisms, including the involvement of cells, key cytokines, and signaling pathways. The potential therapeutic role of RLX in FLDs is outlined, and the application of RLX in the clinical treatment is discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Polymer Science
Hiroyuki Kamata, Satoko Ashikari-Hada, Yusuke Mori, Akihiko Azuma, Ken-ichiro Hata
MACROMOLECULAR RAPID COMMUNICATIONS
(2019)
Article
Medicine, General & Internal
Miwako Omori, Yoshinobu Saito, Yukiko Miura, Toru Tanaka, Takeru Kashiwada, Kenichiro Atsumi, Hiroki Hayashi, Yuji Minegishi, Kazue Fujita, Arata Azuma, Masahiro Seike, Akihiko Gemma
JOURNAL OF NIPPON MEDICAL SCHOOL
(2019)
Article
Genetics & Heredity
Naoto Keicho, Minako Hijikata, Kozo Morimoto, Sakae Homma, Yoshio Taguchi, Arata Azuma, Shoji Kudoh
MOLECULAR GENETICS & GENOMIC MEDICINE
(2020)
Article
Critical Care Medicine
Yasuhiro Kondoh, Arata Azuma, Yoshikazu Inoue, Takashi Ogura, Susumu Sakamoto, Kenji Tsushima, Takeshi Johkoh, Kiminori Fujimoto, Kazuya Ichikado, Yasuo Matsuzawa, Takefumi Saito, Kazuma Kishi, Keisuke Tomii, Noriho Sakamoto, Masahiro Aoshima, Jun Araya, Shinyu Izumi, Machiko Arita, Mitsuhiro Abe, Hiroyoshi Yamauchi, Joe Shindoh, Takafumi Suda, Masaki Okamoto, Masahito Ebina, Yoshihito Yamada, Yuji Tohda, Tetsuji Kawamura, Yoshio Taguchi, Hiroshi Ishii, Naozumi Hashimoto, Shinji Abe, Hiroyuki Taniguchi, Jun Tagawa, Koji Bessho, Natsuki Yamamori, Sakae Homma
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Review
Rheumatology
Masataka Kuwana, Arata Azuma
MODERN RHEUMATOLOGY
(2020)
Letter
Critical Care Medicine
Yasuhiro Kondoh, Arata Azuma, Jun Tagawa, Sakae Homma
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Letter
Critical Care Medicine
Yasuhiro Kondoh, Arata Azuma, Jun Tagawa, Natsuki Yamamori, Sakae Homma
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Letter
Critical Care Medicine
Nadera J. Sweiss, Peter Korsten, Huzaefah J. Syed, Aamer Syed, Robert P. Baughman, Arthur M. F. Yee, Daniel A. Culver, Teresa Sosenko, Arata Azuma, Francesco Bonella, Ulrich Costabel, Wonder P. Drake, Marjolein Drent, Elyse E. Lower, Dominique Israel-Biet, Remy L. M. Mostard, Hilario Nunes, Paola Rottoli, Paolo Spagnolo, Athol U. Wells, Wim A. Wuyts, Marc A. Judson
Article
Cardiac & Cardiovascular Systems
Kenji Yodogawa, Yoshimitsu Fukushima, Takahiro Ando, Yu-ki Iwasaki, Kazuyoshi Akiyama, Shin-ichiro Kumita, Arata Azuma, Yoshihiko Seino, Wataru Shimizu
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Rheumatology
Masataka Kuwana, Takashi Ogura, Shigeki Makino, Sakae Homma, Yasuhiro Kondoh, Aiko Saito, Hiroyuki Ugai, Martina Gahlemann, Kazuhiko Takehara, Arata Azuma
Summary: Nintedanib demonstrated efficacy in Japanese patients with SSc-ILD, showing a slower decline in FVC compared to placebo over 52 weeks. There was no heterogeneity detected in treatment effect between Japanese and non-Japanese patients, and the safety profile of nintedanib in Japanese patients was similar to that in patients with idiopathic pulmonary fibrosis.
MODERN RHEUMATOLOGY
(2021)
Editorial Material
Respiratory System
Yasuo Morimoto, Hena Khatun, Kwok Sang Wilson Yee, Agus Dwi Susanto, Jun-Pyo Myong, Joven Jeremius Tanchuco, Chau-Chyun Sheu, Ngo Quy Chau, Arata Azuma
Article
Rheumatology
James R. Seibold, Toby M. Maher, Kristin B. Highland, Shervin Assassi, Arata Azuma, Laura Kathleen Hummers, Ulrich Costabel, Ute von Wangenheim, Veronika Kohlbrenner, Martina Gahlemann, Margarida Alves, Oliver Distler
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Medicine, General & Internal
Naoyuki Kuse, Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Minoru Inomata, Jiro Usuki, Akemi Morinaga, Toru Tanaka, Takeru Kashiwada, Kenichiro Atsumi, Hiroki Hayashi, Yoshinobu Saito, Masahiro Seike, Akihiko Gemma
JOURNAL OF NIPPON MEDICAL SCHOOL
(2020)
Review
Respiratory System
Arata Azuma, Luca Richeldi
TUBERCULOSIS AND RESPIRATORY DISEASES
(2020)
Article
Respiratory System
Yuji Minegishi, Akihiko Gemma, Sakae Homma, Kazuma Kishi, Arata Azuma, Takashi Ogura, Naoki Hamada, Hiroyuki Taniguchi, Noboru Hattori, Yasuhiko Nishioka, Kiminobu Tanizawa, Takeshi Johkoh, Takuma Yokoyama, Kazutaka Mori, Yoshio Taguchi, Masahito Ebina, Naohiko Inase, Koichi Hagiwara, Hiroshi Ohnishi, Hiroshi Mukae, Yoshikazu Inoue, Kazuyoshi Kuwano, Hirofumi Chiba, Ken Ohta, Yoshinori Tanino, Fumikazu Sakai, Yukihiko Sugiyama
