Article
Pharmacology & Pharmacy
Guangyi Cui, Han Wang, Chongting Yang, Xiaoxiao Zhou, Junyi Wang, Tong Wang, Tonghui Ma
Summary: In this study, it was found that Berberine has potent inhibitory effects on EV71 replication and can significantly reduce mortality in a mouse model of EV71 infection. Berberine achieves these effects by regulating the Keap-Nrf2 axis and reducing ROS generation. This study provides a potential antiviral treatment for severe EV71 infection associated with neurological complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Safa Kinaneh, Walaa Hijaze, Lana Mansour-Wattad, Rawan Hammoud, Hisam Zaidani, Aviva Kabala, Shadi Hamoud
Summary: Heparanase inhibition significantly attenuates the development of liver steatosis by decreasing tissue lipid content and affecting the mRNA expression of key lipid metabolism regulators.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Fernanda M. C. Sodre, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aisha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Summary: In this study, systemic inhibition of peptidylarginine deiminases (PADs) through BB-Cl-amidine treatment prevented diabetes development in NOD mice by reducing citrullination levels in the pancreas, decreasing circulating autoantibody titers, and reducing neutrophil extracellular trap formation. Additionally, the treatment induced a shift in cytokine production and increased regulatory T cell frequency. This highlights the potential of PAD inhibition for treating autoimmune diseases like type 1 diabetes.
Article
Immunology
Nuha Milad Ashtiwi, Demba Sarr, Tamas Nagy, Z. Beau Reneer, Ralph A. Tripp, Balazs Rada
Summary: The combination treatment of OSCN- and AMT shows potential in curing lethal influenza virus infection. Monotherapy with OSCN- or AMT alone does not substantially improve survival outcomes, but the combination treatment significantly inhibits viral replication.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Xiangying Liu, Wenjing Song, Ying Yu, Jianhua Su, Xiaoyan Shi, Xin Yang, Honghui Wang, Peng Liu, Libo Zou
Summary: This study confirmed the impact of NLRP1-dependent pyroptosis on hyperphosphorylation of tau protein and indicated that inhibition of NLRP1-dependent neuronal pyroptosis could improve spatial memory in rats.
NEUROTOXICITY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kirsty Hamilton, Kate Morrow, Ermione Markantoni, Jenni Harvey
Summary: The accumulation of amyloid-beta (A beta) and hyper-phosphorylated tau in the brain is associated with hippocampal synaptic dysfunction and cognitive deficits in Alzheimer's disease (AD). Recent research has found that A beta can lead to mis-localisation of tau in synapses, resulting in impaired synaptic function. However, leptin, a hormone involved in regulating appetite, has been shown to protect against A beta-induced toxicity in AD models. This study demonstrates that leptin can also prevent tau-related synaptic dysfunction, providing further evidence for the neuroprotective properties of leptin in the early stages of AD.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Oncology
Roland Houben, Sonja Hesbacher, Bhavishya Sarma, Carolin Schulte, Eva-Maria Sarosi, Sabine Popp, Christian Adam, Thibault Kervarrec, David Schrama
Summary: GSK3 inhibitors, such as CHIR99021, have been identified as potential therapeutics for Merkel cell carcinoma (MCC) by repressing TA expression in MCC cells, demonstrating in vivo antitumor activity in a MCC xenograft mouse model. This study provides a promising approach for future treatment of MCC by targeting virus-encoded T antigens.
Article
Biochemistry & Molecular Biology
Sophie I. Hamstra, Jessica L. Braun, Stephen P. Chelko, Val A. Fajardo
Summary: Arrhythmogenic cardiomyopathy is a disease characterized by cardiac arrhythmias, myocardial remodeling, and premature death induced by exercise. Recent research has identified the roles of increased GSK3 activity, calcium overload, and mitochondrial dysfunction in the pathogenesis of this disease. These factors ultimately lead to apoptosis and remodeling of myocardial cells. Inhibiting GSK3 activity can improve cardiac function.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Multidisciplinary Sciences
Swati Ghosh, Michael W. W. Devereaux, David J. J. Orlicky, Ronald J. J. Sokol
Summary: Prolonged parenteral nutrition (PN) can lead to PN associated cholestasis (PNAC) due to the activation of NF kappa B. In this study, researchers investigated the inhibition of HNF4 alpha as a potential treatment for PNAC. They found that HNF4 alpha antagonist BI6015 prevented liver damage and inflammation while promoting the expression of bile and sterol transporters. This suggests that HNF4 alpha antagonism could be a therapeutic target for PNAC.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Xiaowen Bi, Baolin Jiang, Jinyi Zhou, Xirui Fan, Xintong Yan, Juanjuan Liang, Lan Luo, Zhimin Yin
Summary: Inhibition of CBP bromodomain effectively blocks HMGB1-mediated inflammatory responses and reduces its pro-inflammatory activity. SGC-CBP30 down-regulates the activation of relevant signaling pathways to decrease the inflammatory effects of HMGB1.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Wenwen Wei, Shujuan Huang, Qing Ling, Shihui Mao, Yu Qian, Wenle Ye, Fenglin Li, Jiajia Pan, Xiangjie Lin, Jiansong Huang, Xin Huang, Yifan Zhai, Jie Sun, Jie Jin
Summary: The combination of APG-2575 and HHT showed synergistic inhibition of AML cell growth and engraftment, providing a potential AML treatment strategy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Xiumei Wu, Mengyun Xu, Zhenghong Liu, Zhidan Zhang, Yujie Liu, Sihui Luo, Xueying Zheng, Peter J. Little, Suowen Xu, Jianping Weng
Summary: This study found that dual inhibition of IRAK1 and IRAK4 can effectively attenuate endothelial inflammation, lower LDL-C levels, and reduce atherosclerosis lesions. The findings support the importance of anti-inflammatory therapies in the treatment of cardiovascular diseases.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Oncology
Ana Casado-Garcia, Marta Isidro-Hernandez, Ninad Oak, Andrea Mayado, Christine Mann-Ran, Javier Raboso-Gallego, Silvia Aleman-Arteaga, Alexandra Buhles, Dario Sterker, Elena G. Sanchez, Jorge Martinez-Cano, Oscar Blanco, Alberto Orfao, Diego Alonso-Lopez, Javier De Las Rivas, Susana Riesco, Pablo Prieto-Matos, Africa Gonzalez-Murillo, Francisco Javier Garcia Criado, Maria Begona Garcia Cenador, Thomas Radimerski, Manuel Ramirez-Orellana, Cesar Cobaleda, Jun J. Yang, Carolina Vicente-Duenas, Andreas Weiss, Kim E. Nichols, Isidro Sanchez-Garcia
Summary: This study demonstrates that early-life administration of the JAK1/2 inhibitor ruxolitinib significantly reduces the risk of B-ALL in mice. This finding presents a potential strategy for preventing the development of B-ALL.
Article
Microbiology
Andrea Arena, Maria Anele Romeo, Agnese Po, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Aurelia Gaeta, Enrico De Smaele, Mara Cirone
Summary: This study demonstrates that inhibition of IRE1 alpha endoribonuclease by 4 mu 8C can prevent EBV-driven lymphomagenesis and B-cell immortalization, suggesting its potential as a therapeutic approach for reducing the risk of PTLD onset in immune-deficient patients. These findings support the hypothesis that 4 mu 8C could be effective even when malignancies have already started to arise. Overall, this study highlights the promising role of IRE1 alpha endoribonuclease inhibition in PTLD treatment.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, Research & Experimental
Changshun He, Bo Jiang, Mo Wang, Pengwei Ren, Sae-Il Murtada, Alexander W. Caulk, Guangxin Li, Lingfeng Qin, Roland Assi, Constantinos J. Lovoulos, Martin A. Schwartz, Jay D. Humphrey, George Tellides
Summary: This study investigates the role of mTOR signaling in aortic disease. The activation of mTOR in vascular wall cells determines whether aortic tears progress to dissection or rupture. Inhibition of mTOR signaling prevents aortic rupture but promotes dissection. Thus, caution should be exercised when exploring mTOR inhibition for aortic disease.
Article
Hematology
Alla Dolnikov, Sylvie Shen, Guy Klamer, Swapna Joshi, Ning Xu, Lu Yang, Kenneth Micklethwaite, Tracey A. O'Brien
EXPERIMENTAL HEMATOLOGY
(2015)
Article
Cell & Tissue Engineering
Sylvie Shen, Ning Xu, Guy Klamer, Kap-Hyoun Ko, Melissa Khoo, David Ma, John Moore, Tracey A. O'Brien, Alla Dolnikov
STEM CELLS AND DEVELOPMENT
(2015)
Letter
Biophysics
M. E. Christensen, L. J. Sinfield, H. Cullup, N. J. Waterhouse, K. Atkinson, A. M. Rice
BONE MARROW TRANSPLANTATION
(2012)
Editorial Material
Oncology
Deborah L. White, Anna L. Brown, Richard J. D'Andrea, Alison M. Rice
Article
Hematology
Sylvie Shen, Guy Klamer, Ning Xu, Tracey A. O'Brien, Alla Dolnikov
EXPERIMENTAL HEMATOLOGY
(2013)
Article
Immunology
Lisa M. Freeman, Alfred Lam, Eugene Petcu, Robert Smith, Ali Salajegheh, Peter Diamond, Andrew Zannettino, Andreas Evdokiou, John Luff, Pooi-Fong Wong, Dalia Khalil, Nigel Waterhouse, Frank Vari, Alison M. Rice, Laurence Catley, Derek N. J. Hart, Slavica Vuckovic
JOURNAL OF IMMUNOLOGY
(2011)
Article
Oncology
Hannah Cullup, Andy K. W. Hsu, Andrew J. Kassianos, Kylie McDonald, Kristen J. Radford, Alison M. Rice
JOURNAL OF IMMUNOTHERAPY
(2011)
Correction
Cell & Tissue Engineering
Rebecca A. Petekanos, Joan Li, Milena Gongora, Vashe Chandrakanthan, Janelle Scown, Norseha Suhaimi, Gary Brooke, Melinda E. Christensen, Tram Doan, Alison M. Rice, Geoffrey W. Osborne, Sean M. Grimmond, Richard P. Harvey, Kerry Atkinson, Melissa H. Little
STEM CELL RESEARCH
(2012)
Article
Cell & Tissue Engineering
Rebecca A. Pelekanos, Joan Li, Milena Gongora, Vashe Chandrakanthan, Janelle Scown, Norseha Suhaimi, Gary Brooke, Melinda E. Christensen, Tram Doan, Alison M. Rice, Geoffrey W. Osborne, Sean M. Grimmond, Richard P. Harvey, Kerry Atkinson, Melissa H. Little
STEM CELL RESEARCH
(2012)
Article
Cell & Tissue Engineering
Matthew M. Cook, Kathryn Futrega, Michael Osiecki, Mahboubeh Kabiri, Betul Kul, Alison Rice, Kerry Atkinson, Gary Brooke, Michael Doran
TISSUE ENGINEERING PART C-METHODS
(2012)
Article
Cell & Tissue Engineering
Guy Klamer, Jessica Sue, Annette Trickett, Kap-Hyoun Ko, Phillip Johnson, Ngaire J. Elwood
Summary: The analysis of the network of public cord blood banks in Australia reveals that stored cord blood units have unique tissue types and HLA alleles associated with specific ethnicities. This suggests that the continuous addition of cord blood units can increase the diversity of HLA and strategic collection sites can facilitate the collection of rare HLA associated with ethnic minority groups. These findings are significant for the field of cell and gene therapy.
Meeting Abstract
Biophysics
H. Cullup, Z. Al-Mansour, D. Chan, H. Niland-Rowe, D. Munster, A. Rice
BONE MARROW TRANSPLANTATION
(2011)
Meeting Abstract
Biophysics
H. Cullup, D. Chan, H. Niland-Rowe, T. Seldon, A. Palkova, M. Christensen, B. Xu, D. Hart, D. Munster, A. Rice
BONE MARROW TRANSPLANTATION
(2011)