Review
Health Care Sciences & Services
Miguel A. Ortega, Cielo Garcia-Montero, Oscar Fraile-Martinez, Paolo Colet, Ardak Baizhaxynova, Kymbat Mukhtarova, Melchor Alvarez-Mon, Kaznagul Kanatova, Angel Asunsolo, Antonio Sarria-Santamera
Summary: This article reviews the latest variants of SARS-CoV-2 and their impact on the global situation. Understanding the mechanisms behind the emergence of these variants is crucial for better management of this pandemic.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Chemistry, Physical
Mandeep Singh, Dario Zappa, Elisabetta Comini
Summary: Fuel cells are becoming increasingly popular as a highly efficient, clean, and sustainable energy conversion source with different types having their own pros and cons. Solid oxide fuel cells (SOFC) are gaining attention for their high efficiency and versatility in utilizing various fuels apart from hydrogen. Recent advancements mainly focus on two types of SOFC stack designs and their implications for medium and large power requirements.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Biology
Alexander J. Tarashansky, Jacob M. Musser, Margarita Khariton, Pengyang Li, Detlev Arendt, Stephen R. Quake, Bo Wang
Summary: SAMap is a new method that can map cell atlas manifolds across species within phyla, identifying homologous cell types with shared expression programs, even in complex examples where homologous tissues emerge from distinct germ layers.
Review
Engineering, Biomedical
Chandralekha Chatterjee, Peter Schertl, Miriam Frommer, Anita Ludwig-Husemann, Anna Mohra, Nadine Dilger, Toufik Naolou, Sophia Meermeyer, Timna Claire Bergmann, Alejandro Alonso Calleja, Cornelia Lee-Thedieck
Summary: Artificial niches play a crucial role in regenerative medicine research, providing insights into the biophysical and biochemical processes of hematopoietic stem cells, as well as facilitating HSCs expansion and targeted differentiation. Due to the lack of natural microenvironment, biomaterials are essential in recreating niche environments, offering promising applications in various fields.
ACTA BIOMATERIALIA
(2021)
Article
Multidisciplinary Sciences
Prakash Kulkarni, Ravi Salgia, Govindan Rangarajan
Summary: Phenotypic plasticity refers to the ability of individual genotypes to produce different phenotypes in response to environmental changes. Previous research has proposed that conformational noise derived from the conformational dynamics of intrinsically disordered proteins (IDPs) can contribute to phenotypic switching by altering the cellular protein interaction network. This review article discusses the progress in understanding this hypothesis, presents empirical evidence supporting it, and identifies key areas for future research.
Review
Nanoscience & Nanotechnology
Jaroslaw Mysliwiec, Alina Szukalska, Adam Szukalski, Lech Sznitko
Summary: The demonstration of the first ruby laser in 1960 sparked a revolution in science and technology, leading to new insights and approaches in various scientific areas. Progress in developing liquid crystalline micro and nano-lasers over the last decade has shown promising applications and future prospects.
Article
Oncology
Laura Crowley, Michael M. Shen
Summary: The recent advancement in single-cell RNA-sequencing technology has provided new insights into the heterogeneity of prostate epithelium. Studies have shown extensive heterogeneity among luminal epithelial cells in different regions of the prostate, with varying progenitor potentials and plasticity in context-dependent environments.
Article
Medicine, Research & Experimental
Ziyang Cui, Hope Wei, Colin Goding, Rutao Cui
Summary: Stem cell pools are homogeneous cell populations that possess self-renewal and differentiation potential. While they exhibit limited heterogeneity during homeostasis, their plasticity becomes apparent under stress, leading to changes in phenotype, constitution, metabolism, and function. Manipulating these factors offers better control of stem cell behavior and has the potential to revolutionize regenerative medicine.
Review
Biotechnology & Applied Microbiology
Zibin Liu, Fang Zeng, Yao Zhang, Yongqing Liu, Zhuo Li, Xiao Liu
Summary: With the aging population growing, the number of patients with retinal degeneration causing vision loss is also increasing. Stem cell therapies offer hope for regeneration and repair of damaged retinal tissue, while exosomes derived from stem cells could be a novel cell-free therapeutic strategy in regenerative medicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Marius Lange, Volker Bergen, Michal Klein, Manu Setty, Bernhard Reuter, Mostafa Bakhti, Heiko Lickert, Meshal Ansari, Janine Schniering, Herbert B. Schiller, Dana Pe'er, Fabian J. Theis
Summary: Computational trajectory inference is a method to reconstruct cell state dynamics from single-cell RNA sequencing experiments, but it requires prior knowledge of the direction of biological processes. CellRank is a new approach that allows single-cell fate mapping in scenarios where the direction is unknown, such as regeneration, reprogramming, and disease.
Article
Multidisciplinary Sciences
Hanbing Song, Hannah N. W. Weinstein, Paul Allegakoen, Marc H. Wadsworth, Jamie Xie, Heiko Yang, Ethan A. Castro, Kevin L. Lu, Bradley A. Stohr, Felix Y. Feng, Peter R. Carroll, Bruce Wang, Matthew R. Cooperberg, Alex K. Shalek, Franklin W. Huang
Summary: The study characterized the microenvironment response to prostate cancer using single-cell RNA-seq and organoids, identifying tumor-associated epithelial cell states and club cells.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Landon J. J. Rohowetz, Peter Koulen
Summary: The eyes are immune privileged organs, making them ideal for stem cell therapy. Differentiation protocols for retinal pigment epithelium (RPE) from embryonic and induced pluripotent stem cells have been developed, allowing diseases affecting RPE to be treated with stem cell therapy. Recent advancements in diagnostic technologies have enhanced disease monitoring and response to stem cell therapy. Previous clinical trials have shown promising results, and ongoing trials aim to improve our understanding of the most effective methods of RPE-based stem cell therapy for retinal diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ricardo F. H. Giehl, Paulina Flis, Jorg Fuchs, Yiqun Gao, David E. Salt, Nicolaus von Wiren
Summary: In this study, a method combining fluorescence-activated cell sorting (FACS) with inductively coupled plasma mass spectrometry (ICP-MS) was developed to assess the ionome of different cell populations within Arabidopsis thaliana roots. The results showed that most elements exhibited a radial concentration gradient increasing from the rhizodermis to inner cell layers, and previously unknown ionomic changes were detected due to perturbed xylem loading processes. Additionally, a strong accumulation of manganese in trichoblasts of iron-deficient roots was identified. These findings indicate the existence of cell type-specific constraints for efficient metal sequestration in roots.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Emily M. Holloway, Michael Czerwinski, Yu-Hwai Tsai, Joshua H. Wu, Angeline Wu, Charlie J. Childs, Katherine D. Walton, Caden W. Sweet, Qianhui Yu, Ian Glass, Barbara Treutlein, J. Gray Camp, Jason R. Spence
Summary: Through studying human intestinal development, it was found that smooth muscle cells of the muscularis mucosa release WNT and RSPONDIN ligands near proliferative crypts, while a mesenchymal population with high expression of PDGFRA(HI)/F3(HI)/DLL1(HI) serves as a source of NEUREGULIN1 (NRG1). NRG1 promotes increased cellular diversity through differentiation of secretory lineages.
Article
Geosciences, Multidisciplinary
Xuejiao Hou, Lian Feng, Yanhui Dai, Chuanmin Hu, Luke Gibson, Jing Tang, Zhongping Lee, Ying Wang, Xiaobin Cai, Junguo Liu, Yi Zheng, Chunmiao Zheng
Summary: Algal blooms, an emerging threat to global inland water quality, are occurring more frequently, especially in developing countries in Asia and Africa where agricultural fertilizer is heavily used. The establishment of a global bloom database is crucial for future risk assessments and mitigation efforts.