Article
Biochemistry & Molecular Biology
Zachary D. Crees, Michael P. Rettig, Reyka G. Jayasinghe, Keith Stockerl-Goldstein, Sarah M. Larson, Illes Arpad, Giulio A. Milone, Massimo Martino, Patrick Stiff, Douglas Sborov, Denise Pereira, Ivana Micallef, Gemma Moreno-Jimenez, Gabor Mikala, Maria Liz Paciello Coronel, Udo Holtick, John Hiemenz, Muzaffar H. Qazilbash, Nancy Hardy, Tahir Latif, Irene Garcia-Cadenas, Abi Vainstein-Haras, Ella Sorani, Irit Gliko-Kabir, Inbal Goldstein, Debby Ickowicz, Liron Shemesh-Darvish, Shaul Kadosh, Feng Gao, Mark A. Schroeder, Ravi Vij, John F. DiPersio
Summary: Autologous hematopoietic stem cell transplantation (ASCT) improves survival in multiple myeloma (MM). Motixafortide combined with G-CSF significantly improves the collection of CD34(+) hematopoietic stem cells compared to G-CSF alone. Motixafortide + G-CSF demonstrates superior efficacy in ASCT.
Article
Chemistry, Medicinal
Iris Cadima-Couto, Alexandra Tauzin, Joao M. Freire, Tiago N. Figueira, Ruben D. M. Silva, Clara Perez-Peinado, Catarina Cunha-Santos, Ines Bartolo, Nuno Taveira, Lurdes Gano, Joao D. G. Correia, Joao Goncalves, Fabrizio Mammano, David Andreu, Miguel A. R. B. Castanho, Ana Salome Veiga
Summary: The anti-HIV-1 peptide pepRF1, derived from the Dengue virus capsid protein, shows promising inhibitory effects with a potential therapeutic window higher than 53,000. It specifically targets CXCR4-tropic strains, preventing viral entry into target cells by acting as an antagonist of the viral coreceptor CXCR4. Compared to T20, a peptide-based HIV-1 entry inhibitor, pepRF1 is more effective and can potentially be used alone or in combination with other anti-HIV drugs, as well as a novel therapeutic strategy for other CXCR4-related diseases.
ACS INFECTIOUS DISEASES
(2021)
Article
Oncology
Lisa Marie Kaiser, Mirja Harms, Daniel Sauter, Vijay P. S. Rawat, Mirco Glitscher, Eberhard Hildt, Daniel Tews, Zachary Hunter, Jan Muench, Christian Buske
Summary: Waldenstrom's Macroglobulinemia is a B-cell lymphoma with aggressive disease in patients with CXCR4 mutations. A natural peptide called EPIX4 and its derivatives have shown to impair lymphoma cell growth, indicating potential novel therapies in Waldenstrom's Macroglobulinemia.
Article
Biochemistry & Molecular Biology
Mastaneh Safarnejad Shad, Sandra Claes, Eline Goffin, Tom Van Loy, Dominique Schols, Steven De Jonghe, Wim Dehaen
Summary: The expansion of the structure-activity relationship study of CXCR4 antagonists led to the synthesis of a series of isoquinolines with excellent activity, among which compound 24c showed consistently low nanomolar activity in various assays and was deemed the most promising.
Article
Chemistry, Multidisciplinary
Dipankar Chaudhuri, Tiangong Lu, Binu Jacob, Sojan Abraham, Premlata Shankar, Michael A. Poss, Nouri Neamati, Julio A. Camarero
Summary: The CXCR4 chemokine is a crucial regulator of leukocyte functions, embryonic development, and cancer progression. CXCR4 antagonists show promise as therapeutic agents for cancer and HIV. This study shows that lipidation can improve the half-life of a bioactive cyclotide antagonist, but the choice of lipid may affect its biological activity.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Hematology
Stephania Libreros, Robert Nshimiyimana, Brendon Lee, Charles N. Serhan
Summary: Neutrophils in the bone marrow are regulated by resolvins, which are signaling molecules produced during infections. These resolvins control the production and release of neutrophils, as well as their infiltration to sites of infection. They also regulate the population of reparative monocytes and granulocytes in the bone marrow.
Article
Microbiology
Rostyslav Bilyy, Quentin Pagneux, Nathan Francois, Galyna Bila, Roman Grytsko, Yuri Lebedin, Alexandre Barras, Jean Dubuisson, Sandrine Belouzard, Karin Seron, Rabah Boukherroub, Sabine Szunerits
Summary: This study introduces a method of antigen conjugation using nanodiamond-based adjuvants to induce immune response through neutrophil-driven self-limiting inflammation. Experimental results demonstrate that the adjuvant is safe and effective, capable of inducing persistent high-level antibodies in animal models.
Review
Immunology
Andrea Rubio-Ponce, Andres Hidalgo, Ivan Ballesteros
Summary: This review explores the emerging notion of heterogeneity within the neutrophil pool and evolving concepts in the field, focusing on neutrophil differentiation in the bone marrow and plasticity in tissues. It discusses limitations in exploring neutrophil heterogeneity using single-cell analyses and suggests state-of-the-art alternatives to improve their characterization, proposing strategies for therapeutic benefit.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ae Ri Kim, Eun-Jung Bak, Yun-Jung Yoo
Summary: This study investigated the involvement of CXCR4 in the distribution of neutrophils and monocytes/macrophages, suggesting that CXCR4 plays a role in the circulation of these cells in the blood during inflammatory conditions such as periodontitis. The results indicate that while the CXCR4 antagonist increased neutrophil and monocyte/macrophage populations in the blood, it did not alter their levels in the inflamed peripheral tissues.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Si-wei Wang, Qing Zhang, Dan Lu, You-chen Fang, Xiao-ci Yan, Jing Chen, Zhi-kan Xia, Qian-ting Yuan, Lin-hai Chen, Yang-ming Zhang, Fa-jun Nan, Xin Xie
Summary: Acute lung injury (ALI) is a severe condition that can lead to acute respiratory distress syndrome (ARDS) with high mortality rate. Inflammation, particularly involving neutrophils, is believed to be a major factor in the development of ALI. The discovery of the role of GPR84, a medium chain fatty acid receptor, in regulating neutrophil functions in ALI provides new insights and potential drug targets for treatment.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell Biology
Jiachi Ma, Wanqing Liang, Yaosheng Qiang, Lei Li, Jun Du, Chengwu Pan, Bangling Chen, Chensong Zhang, Yuzhong Chen, Qingkang Wang
Summary: The study investigated the cooperative role of CXCR4/CXCL12 axis and IL-1Ra in the metastasis of colorectal cancer cells. It was found that IL-1 alpha and rIL-1 alpha promoted CXCL12 expression, while IL-1Ra inhibited this effect. Additionally, CXCL12 enhanced migration and proliferation of endothelial cells, and IL-1Ra inhibited migration, proliferation, and angiogenesis of colorectal cancer cells.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Immunology
Zeyu Sun, Wenhua Huang, Yuling Zheng, Peng Liu, Wenbo Yang, Zinan Guo, Decong Kong, Qingyu Lv, Xinyu Zhou, Zongmin Du, Hua Jiang, Yongqiang Jiang
Summary: The research discovered that mice without the Fpr2 receptor were highly susceptible to GBS infections, showing decreased chemotaxis of neutrophils, decreased bactericidal ability of neutrophils, and high mortality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Naveed Akbar, Adam T. Braithwaite, Emma M. Corr, Graeme J. Koelwyn, Coen van Solingen, Clement Cochain, Antoine-Emmanuel Saliba, Alastair Corbin, Daniela Pezzolla, Malene Moller Jorgensen, Rikke Baek, Laurienne Edgar, Carla De Villiers, Mala Gunadasa-Rohling, Abhirup Banerjee, Daan Paget, Charlotte Lee, Eleanor Hogg, Adam Costin, Raman Dhaliwal, Errin Johnson, Thomas Krausgruber, Joey Riepsaame, Genevieve E. Melling, Mayooran Shanmuganathan, Christoph Bock, David R. F. Carter, Keith M. Channon, Paul R. Riley, Irina A. Udalova, Kathryn J. Moore, Daniel Anthony, Robin P. Choudhury
Summary: Acute myocardial infarction leads to a rapid increase in blood neutrophils. While chemokine elevation has been considered their source, this study shows that endothelial cell activation can release extracellular vesicles (EVs) that promote mobilization of neutrophils from the spleen to peripheral blood. These EVs carry VCAM-1 and miRNA-126, and their accumulation in the spleen induces inflammatory gene expression and mobilizes splenic neutrophils.
CARDIOVASCULAR RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Jin Yan, Yang Wang, Xiao Li, Dongnan Guo, Zhengjun Zhou, Ge Bai, Jianhui Li, Na Huang, Jiajie Diao, Yong Li, Wangxiao He, Wenjia Liu, Kaishan Tao
Summary: Self-assembling peptide hydrogels present a promising approach for treating liver bleeding, with a nano-band-aid (NBA) developed through a three-stage self-assembly process of two functionalized peptides demonstrating rapid and effective control of bleeding in animal experiments.
Article
Immunology
Xinying Guo, Negar Khosraviani, Sneha Raju, Joshya Singh, Nikki Zamani Farahani, Madlene Abramian, Victor J. Torres, Kathryn L. Howe, Jason E. Fish, Andras Kapus, Warren L. Lee
Summary: English Summary: ACKR1 is a cell surface protein expressed on erythrocytes and endothelial cells, and is involved in regulating innate immunity. Exposure to whole blood induces ACKR1 mRNA and protein expression in primary human lung microvascular endothelial cells, which requires contact with neutrophils. ACKR1 expression is regulated by NF-kappa B, and the protein is rapidly secreted by extracellular vesicles upon removal of blood. Endogenous ACKR1 does not signal upon stimulation with IL-8 or CXCL1. These findings provide a simple method for inducing endogenous endothelial ACKR1 protein and facilitate further functional studies.
FRONTIERS IN IMMUNOLOGY
(2023)