Article
Immunology
Jun-peng Zhou, Chang-hai Liu, Bo-wen Liu, You-juan Wang, Mohammed Benghezal, Barry James Marshall, Hong Tang, Hong Li
Summary: This study aimed to investigate the impact of H. pylori infection on serum levels of pepsinogens and gastrin-17. The study found that H. pylori-positive subjects had higher levels of pepsinogens and gastrin-17, while the pepsinogen-I/II ratio was lower. Compared to H. pylori-negative subjects, H. pylori-positive subjects were less likely to have gastric atrophy but had a greater risk of severe gastritis or peptic ulcers.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Maidina Abuduwaili, Hidehiko Takigawa, Ryo Yuge, Hajime Teshima, Takahiro Kotachi, Yuji Urabe, Masanori Ito, Kazuhiro Sentani, Naohide Oue, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka
Summary: This study aimed to investigate the relationship between NHPH infection and gastritis and gastric cancer development. The results showed no significant difference in NHPH infection rates based on different Hp infection statuses, and the NHPH infection rates in gastric cancer patients were similar to those in patients with gastritis-related diseases reported in previous studies. A comparison between NHPH-positive and negative patients showed no significant differences in atrophic gastritis status, serum gastritis markers, or clinicopathological characteristics of gastric cancer.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Orsolya Anna Simon, Aniko Gorbe, Peter Hegyi, Lajos Szako, Eduard Ostarijas, Fanni Dembrovszky, Szabolcs Kiss, Laszlo Czopf, Balint Eross, Imre Szabo
Summary: This study found an association between H. pylori infection and increased carotid intima-media thickness through a systematic review and meta-analysis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Yuexi Li, Xiaoqin Liu, Yuhan Luo, Qiaoli Wang
Summary: This study quantitatively elucidated the association between pepsinogen ratio (PGR) and brachial-ankle pulse wave velocity (baPWV), revealing a nonlinear relationship between PGR and baPWV. Lower levels of PGR were linearly and inversely correlated with baPWV, while higher levels showed no significant linear relationship.
BMC CARDIOVASCULAR DISORDERS
(2023)
Review
Medicine, General & Internal
Xianghong Wang, Qian He, Donghua Jin, Baohua Ma, Kecheng Yao, Xiulan Zou
Summary: This meta-analysis confirmed a significant association between H. pylori infection and subclinical atherosclerosis, indicating a strong correlation with clinical significance. Sensitivity analyses showed robust results, and no significant publication bias was detected.
Article
Gastroenterology & Hepatology
Xue-Chun Yu, Qiao-Qiao Shao, Jing Ma, Miao Yu, Chen Zhang, Lei Lei, Yang Zhou, Wen-Chao Chen, Wei Zhang, Xin-Hui Fang, Yuan-Zeng Zhu, Gang Wu, Xue-Mei Wang, Shuang-Yin Han, Pei-Chun Sun, Song-Ze Ding
Summary: This study investigated the family-based infection status, related factors, and transmission patterns of Helicobacter pylori in central China. The results showed that the infection rate was 54.27%, with at least one infected individual in 87.23% of healthy households. Furthermore, in 27.24% of these infected households, all members were infected. Individuals with a higher education level had lower infection rates.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Peripheral Vascular Disease
Danmei He, Lan Gao, Ying Yang, Jia Jia, Yimeng Jiang, Pengfei Sun, Bo Liu, Jianping Li, Fangfang Fan, Yan Zhang, Yong Huo
Summary: This study found that both cfPWV and baPWV are associated with increased cIMT in a Chinese community-based population. Furthermore, cfPWV is more strongly correlated with increased cIMT compared to baPWV.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Maria del Mar Vila, Laura Igual, Beatriz Remeseiro, Roberto Elosua, Rafel Ramos, Jose M. Valdivielso, Ruth Marti-Lluch, Jaume Marrugat, Maria Grau
Summary: This study assessed the correlation between biomarkers of lower limb atherosclerosis and carotid atherosclerosis. The results showed a linear trend between ankle-brachial index and common carotid intima-media thickness in men, and women with peripheral artery disease had a higher risk of atherosclerotic plaque in the carotid artery.
Review
Gastroenterology & Hepatology
Francesco Di Mario, Pellegrino Crafa, Alberto Barchi, Lorella Franzoni, Marilisa Franceschi, Michele Russo, Ludovica Bricca, Lorenzo Brozzi, Kryssia Rodriguez Castro, Massimo Rugge
Summary: PgII serology has clinical value in assessing gastric inflammation and as a marker of H. pylori infection status, but its reliability is lower in distinguishing between successfully eradicated and persistently infected patients.
Article
Biochemistry & Molecular Biology
Meiping Xiao, Zhiying Zhang, Guanghong Liao, Min Liu, Xuehong Chen
Summary: This study aimed to explore the value of the Helicobacter pylori test combined with plasma pepsinogen (PG) and gastrin 17 in screening the precancerous status and gastric cancer in healthy individuals. The results showed that Hp-positive infection was significantly higher in the gastric cancer group compared to the precancerous disease group, precancerous lesion group, and control group. The CagA positive rates and G-17 levels were also higher in the gastric cancer group, and the PGI/II ratio was lower. As the disease progressed, G-17 levels increased while the PGI/II ratio decreased.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Xin-Yu Fu, Xin-Li Mao, Hao-Wen Wu, Jia-Ying Lin, Zong-Qing Ma, Zhi-Cheng Liu, Yue Cai, Ling-Ling Yan, Yi Sun, Li-Ping Ye, Shao-Wei Li
Summary: Gastric cancer is a major health concern in China. However, large-scale endoscopic screening is not feasible and a more appropriate approach would be to initially screen high-risk groups. In a study of asymptomatic participants, a predictive model for gastric cancer risk was developed using various assessments. The study shows that excluding H. pylori IgG from the prediction model does not significantly affect its performance, which has important implications for optimizing screening indicators and reducing expenditures.
PREVENTIVE MEDICINE
(2023)
Article
Ophthalmology
Lovro Bojic, Veljko Rogosic, Domagoj Markovic, Lucija Vanjaka Rogosic, Duska Glavas
Summary: This study assessed ultrasound measurements of brachial artery flow-mediated dilation (FMD) and carotid artery intima-media thickness (IMT) and their relationship in glaucoma patients. The results showed that glaucoma patients had significantly lower brachial FMD values compared to controls, while carotid IMT values did not differ significantly. The study also found a negative correlation between brachial FMD values and both carotid IMT and brachial artery diameter at rest.
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Peripheral Vascular Disease
Bo Liu, Lan Gao, Bo Zheng, Ying Yang, Jia Jia, Pengfei Sun, Yimeng Jiang, Kaiyin Li, Jiahui Liu, Chuyun Chen, Jianping Li, Fangfang Fan, Yan Zhang, Yong Huo
Summary: This study evaluated and compared the relationships between pulse wave velocity (PWV) and carotid plaque, finding that both carotid-femoral PWV (cfPWV) and brachial-ankle PWV (baPWV) were independently associated with carotid plaque. Furthermore, cfPWV was more strongly correlated with carotid plaque than baPWV in participants with baseline baPWV >= 16.85 m/s.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Medicine, General & Internal
Hideki Mori, Hidekazu Suzuki, Juntaro Matsuzaki, Kaori Kameyama, Koji Igarashi, Tatsuhiro Masaoka, Takanori Kanai
Summary: The present study investigated the usefulness of plasma ghrelin levels as a marker for gastric mucosal atrophy and as a risk stratification marker for gastric cancer, even after H. pylori eradication.
ANNALS OF MEDICINE
(2022)