Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Zhuo Xie, Zongshan Shen, Peimeng Zhan, Jiayu Yang, Qiting Huang, Shuheng Huang, Lingling Chen, Zhengmei Lin
Summary: Treatment of pulpal and periapical diseases faces challenges, but significant progress has been made in achieving true pulp tissue regeneration through technologies such as stem cells, biomaterials, and growth factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Xu-Dong Wang, Wei-Jia Yu, Jia-Hui Liu, Jie Du, Kang-Nan Chen, Qin-Qin Hu, Wen-Long Sun, Guo-Qing Ying
Summary: This study investigated a long-acting strategy for modifying rhG-CSF with C15-MAL, which significantly increased its serum half-life and showed potential as a novel drug candidate. The modified C15-rhG-CSF retained its bioactivity and demonstrated improved efficacy compared to other existing treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Aleksandar Jakovljevic, Jelena Jacimovic, Anita Aminoshariae, Helena Fransson
Summary: This systematic review found no significant differences in effectiveness between compared vital pulp treatments in managing nontraumatic pulpitis associated with no or nonspontaneous pain. However, the existing evidence is limited, and further high-quality randomized controlled trials are needed to investigate the effectiveness of direct pulp capping or pulpotomy (partial/full) compared to selective or stepwise caries removal.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Dua Abuarqoub, Rand Zaza, Nazneen Aslam, Hanan Jafar, Suzan Zalloum, Renata Atoom, Abdalla Awidi
Summary: This study investigates the effect of Biodentine(TM) on odonto/osteogenic differentiation potential of hDPSCs in vitro. The results show that treatment with BD significantly increases the expression of odonto/osteogenic markers, upregulates genes related to the odonto/osteogenesis pathway, and enhances calcium deposits, suggesting BD as a promising candidate for regenerative medicine in dental tissue regeneration.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Angelo Borsarelli Carvalho de Brito, Rachel P. Riechelmann, Victor Hugo Fonseca de Jesus
Summary: This study examined the impact of primary prophylaxis (PP) with granulocyte colony-stimulating factor (G-CSF) on the frequency of neutropenia and survival outcomes in patients with metastatic pancreatic adenocarcinoma (MPA) treated with FOLFIRINOX. The results showed that although the frequency of grade 3/4 neutropenia decreased, the risk of febrile neutropenia (FN) was low in the FOLFIRINOX treatment group without G-CSF, and it was not justified for routine use. However, further studies are needed to assess the potential role of G-CSF in improving survival in MPA patients treated with FOLFIRINOX.
Article
Biotechnology & Applied Microbiology
Rui Chen, Yujie Li, Yangyang Zhuang, Yiming Zhang, Hailong Wu, Tao Lin, Shixuan Chen
Summary: This study combines GM-CSF and 3D nanofiber scaffolds to promote tissue regeneration. Through subcutaneous implantation in humanized mice, it was found that GM-CSF could accelerate cell migration and cytokine release, and ultimately enhance tissue regeneration. Therefore, GM-CSF loaded 3D nanofiber scaffolds have potential applications in tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Raul Rosales-Ibanez, Nieves Cubo-Mateo, Amairany Rodriguez-Navarrete, Arely M. Gonzalez-Gonzalez, Tomas E. Villamar-Duque, Leticia O. Flores-Sanchez, Luis M. Rodriguez-Lorenzo
Summary: The study aimed to test the potential of dental pulp stem cells to attach, proliferate, mineralize and differentiate on 3D printed polycaprolactone (PCL) scaffolds. The results of cell viability tests, von Kossa and Alizarin red staining demonstrate the printed scaffolds' ability to support DPSCs attachment, proliferation, differentiation and mineralization. The selected material-processing technique-cell line (PCL-3D printing-DPSCs) triplet can be used for further modeling and preclinical experiments in bone engineering studies.
Review
Cell Biology
Ashraf Al Madhoun, Sardar Sindhu, Dania Haddad, Maher Atari, Rasheed Ahmad, Fahd Al-Mulla
Summary: Dental pulp stem cells have promising characteristics, but genotypic and phenotypic heterogeneities may impact their therapeutic potentials. Studies suggest that their heterogeneity arises from an interplay between intrinsic and extrinsic factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Eva-Maria Klein, Sandra Sauer, Sabrina Klein, Diana Tichy, Axel Benner, Uta Bertsch, Juliane Brandt, Christoph Kimmich, Hartmut Goldschmidt, Carsten Muller-Tidow, Karin Jordan, Nicola Giesen
Summary: This study compared antibiotic prophylaxis with G-CSF support as anti-infective strategies in patients with multiple myeloma undergoing HDT/ASCT, showing that G-CSF support is associated with a shorter duration of hospitalization and a lower rate of emerging multidrug resistant bacteria.
Article
Biochemistry & Molecular Biology
Manuel Mata, Santiago Peydro, Jose Javier Martin de Llano, Maria Sancho-Tello, Carmen Carda
Summary: Periodontitis is an inflammatory disease that can lead to tooth loss. This study examined the role of surface microtopography in the differentiation of human dental pulp stem cells into cementoid-like secreting cells. The results showed that the cells cultured on dentin surfaces exhibited an odontoblastic phenotype, while cells cultured on cementum surfaces generated a well-organized tissue consisting of secretory cells and dense fibrous connective tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Wenxue Dou, Jiaye Xie, Jianan Chen, Jiajun Zhou, Zunyue Xu, Zheng Wang, Qiang Zhu
Summary: This study demonstrated that overexpression of adrenomedullin (ADM) can promote the proliferation of human dental pulp stem cells (DPSCs) and inhibit cellular senescence. By inhibiting miR-152 and promoting CCNA2 expression, ADM-overexpressing DPSCs can promote cell cycle progression and resist aging.
Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Cell & Tissue Engineering
Jie Chen, Huaxing Xu, Kun Xia, Shuhua Cheng, Qi Zhang
Summary: In this study, it was found that RvE1 promotes pulp inflammation resolution and dentin regeneration, and positively influences the proliferation, chemotaxis, and differentiation of LPS-stimulated hDPSCs. The effects of RvE1 on DPSCs were mediated at least partially through AKT, ERK, and rS6-associated signaling in the inflammatory microenvironment. RvE1 shows promising application potential in regenerative endodontics.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Clinical Neurology
Mahsa Vafaei Mastanabad, Aref Nooraei, Mahgol Sadat Hassan Zadeh Tabatabaei, Amir Akbari Fakhrabadi, Faria Jafarzadeh
Summary: This article introduces the basics of amyotrophic lateral sclerosis (ALS) and G-CSF, and comprehensively reviews the applications of G-CSF in clinical and pre-clinical studies, emphasizing the significant efficacy in pre-clinical studies and the failure to replicate the results in clinical studies.
ACTA NEUROLOGICA BELGICA
(2023)
