Article
Urology & Nephrology
Hae-Ryong Yun, Young Su Joo, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Nak-Hoon Son, Tae-Hyun Yoo, Shin-Wook Kang, Suah Sung, Kyu-Beck Lee, Joongyub Lee, Kook-Hwan Oh, Seung Hyeok Han
Summary: An elevated coronary artery calcification score (CACS) is associated with increased cardiovascular disease risk in patients with CKD. The study found that higher CACS is also associated with a significantly increased risk of adverse kidney outcomes and CKD progression.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Tadatoshi Sato, Christian D. Castro Andrade, Sung-Hee Yoon, Yingshe Zhao, William J. Greenlee, Patricia C. Weber, Usha Viswanathan, John Kulp, Daniel J. Brooks, Marie B. Demay, Mary L. Bouxsein, Bruce Mitlak, Beate Lanske, Marc N. Wein
Summary: This study identifies SIK2/SIK3 as potential drug targets for treating osteoporosis and successfully develops an orally available SIK2/SIK3 inhibitor. The inhibitor stimulates bone formation and increases bone density without apparent toxicity. These findings provide a new approach for the pharmacological treatment of osteoporosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Urology & Nephrology
Neil Roy, Sylvia Eleni Rosas
Summary: Erectile dysfunction is common in individuals on hemodialysis and significantly associated with increased coronary artery calcification, but not associated with increased mortality in incident dialysis patients with no history of coronary artery disease.
JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Kazuhiro Shiizaki, Asako Tsubouchi, Yutaka Miura, Kinya Seo, Takahiro Kuchimaru, Hirosaka Hayashi, Yoshitaka Iwazu, Marina Miura, Batpurev Battulga, Nobuhiko Ohno, Toru Hara, Rina Kunishige, Mamiko Masutani, Keita Negishi, Kazuomi Kario, Kazuhiko Kotani, Toshiyuki Yamada, Daisuke Nagata, Issei Komuro, Hiroshi Itoh, Hiroshi Kurosu, Masayuki Murata, Makoto Kuro-O
Summary: The Western pattern diet is rich not only in fat and calories, but also in phosphate, which can lead to kidney damage. Excessive phosphate intake triggers an increase in circulating FGF23 levels, promoting phosphate excretion and damaging renal structures. The study identifies renal tubular fluid calcium phosphate particles as an effective therapeutic target to slow down nephron loss during aging and CKD progression.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Haitao Zhang, Guisen Li, Xueqing Yu, Junwei Yang, Aili Jiang, Hong Cheng, Junzhou Fu, Xinling Liang, Jun Liu, Jizhuang Lou, Mei Wang, Changying Xing, Aihua Zhang, Miao Zhang, Xiangcheng Xiao, Chen Yu, Rong Wang, Li Wang, Yuqing Chen, Tianjun Guan, Ai Peng, Nan Chen, Chuanming Hao, Bicheng Liu, Suxia Wang, Dan Shen, Zhenhua Jia, Zhihong Liu
Summary: Baseline findings from the China Dialysis Calcification Study revealed a high prevalence of vascular calcification among patients with end-stage kidney disease, but data on calcification progression were limited. This study aimed to understand the progression of calcification at different anatomical sites, identify risk factors, and assess the association with cardiovascular events and death. The results may have implications for improving the management of chronic kidney disease-mineral and bone disorder among dialysis patients.
Article
Hematology
Yifei Ge, Buyun Wu, Xiangbao Yu, Ningning Wang, Xueqiang Xu, Ming Zeng, Bo Zhang, Huijuan Mao, Changying Xing
Summary: Sclerostin is significantly elevated in dialysis patients with CAC. Patients with CAC are older, have lower Kt/V, and higher levels of serum sclerostin. However, in the survival group, patients are younger with lower levels of sclerostin and CAC scores.
BLOOD PURIFICATION
(2022)
Article
Urology & Nephrology
Neil Roy, Sylvia E. Rosas
Summary: The study found that higher IL-6 levels were associated with higher baseline CAC score and increased progression of CAC and mortality in incident dialysis patients. After adjusting for other factors, IL-6 levels were found to be positively correlated with mortality.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Xiaoling Zhou, Yidan Guo, Yang Luo
Summary: The study found an association between serum intact parathyroid hormone levels and mortality in hemodialysis patients, showing a U-shaped curve of this relationship. The optimal range of serum iPTH levels conferring the lowest risk of all-cause and cardiovascular mortality may range from 150 pg/mL to 450 pg/mL in this group of incident HD patients.
Article
Multidisciplinary Sciences
Hiroki Okabe, Yoshitaka Muraoka, Yutaro Naka, Koshi Setoyama, Konosuke Inoue, Toshiya Miura, Akiyoshi Shimizu, Reo Anai, Tetsu Miyamoto, Yuki Tsuda, Masaru Araki, Shinjo Sonoda, Masaharu Kataoka
Summary: Nutritional status has a significant effect on coronary atherosclerosis in hemodialysis patients, and malnutrition can lead to the progression of coronary artery disease. Optical coherence tomography can be used to evaluate the impact of nutritional status on coronary atherosclerosis in hemodialysis patients.
Article
Medicine, Research & Experimental
Hanna Taipaleenmaeki, Hiroaki Saito, Saskia Schroeder, Miki Maeda, Ramona Mettler, Matthias Ring, Ewa Rollmann, Andreas Gasser, Carl Haasper, Thorsten Gehrke, Alexander Weiss, Steffen K. Grimm, Eric Hesse
Summary: The study showed that PTH and Scl-Ab can decrease the expression of miR-19a/b in bones, while antagonizing miR-19a/b can increase bone mass. Furthermore, antagonizing miR-19a/b enhances bone mass gain and restores bone loss by supporting bone formation and decreasing bone resorption.
EMBO MOLECULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Connie M. Rhee, Matthew Budoff, Gregory Brent, Amy S. You, Peter Stenvinkel, Alejandra Novoa, Ferdinand Flores, Sajad Hamal, Christopher Dailing, April Kinninger, Tracy Nakata, Csaba P. Kovesdy, Danh V. Nguyen, Kamyar Kalantar-Zadeh
Summary: This study aimed to investigate the association between serum TSH levels and CAC risk in hemodialysis patients. The results showed that higher serum TSH levels were associated with elevated CAC VS and AS.
CARDIORENAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Joongyub Lee, Yun Kyu Oh, Ji Yong Jung, Kyu-Beck Lee, Kook-Hwan Oh, Seong Kwon Ma, Eun Hui Bae, Soo Wan Kim
Summary: High serum adiponectin level is associated with adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
In Young Choi, Yoosoo Chang, Yoosun Cho, Jeonggyu Kang, Hyun-Suk Jung, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
Summary: This study investigated the associations between prediabetes defined by different criteria and coronary artery calcification (CAC) and its progression. The results showed that individuals meeting both glucose and HbA1c criteria had the highest risk of CAC and CAC progression. All three types of prediabetes showed a significantly increased risk of CAC progression. It is important to manage atherosclerosis risk in individuals with prediabetes, especially those meeting both criteria.
DIABETES OBESITY & METABOLISM
(2022)
Review
Urology & Nephrology
Chong Huang, Zhibing Duan, Chengyun Xu, Yan Chen
Summary: This systematic review and meta-analysis examined the effects of sodium thiosulfate (STS) on coronary artery calcification (CAC) in dialysis patients. The study found that intravenous STS was associated with a significant reduction in CAC scores compared to usual care without STS in dialysis patients.
Review
Pharmacology & Pharmacy
Chenggui Zhang, Chunli Song
Summary: Combination therapy for osteoporosis can have different outcomes, with the combination of teriparatide and denosumab showing the most significant benefits. Further research is needed to determine optimal treatment strategies and methods.
FRONTIERS IN PHARMACOLOGY
(2021)