Article
Physiology
Tiffany J. Glass, Joanie E. Figueroa, John A. Russell, Brittany N. Krekeler, Nadine P. Connor
Summary: The study showed that aging has a significant impact on the contractile properties and MyHC profiles of retrusive tongue muscles, but tongue exercise does not alter these effects.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Oncology
Margarita Artemenko, Sophia S. W. Zhong, Sally K. Y. To, Alice S. T. Wong
Summary: p70(S6K) plays a critical role in protein synthesis, cell growth, and cancer progression, and its activation is associated with poor prognosis in certain cancer types. In addition to mTOR-targeted drugs, there are emerging p70(S6K)-selective drugs under development.
Article
Geriatrics & Gerontology
Kohei Yamaguchi, Koji Hara, Kazuharu Nakagawa, Kanako Yoshimi, Chantaramanee Ariya, Ayako Nakane, Junichi Furuya, Haruka Tohara
Summary: Age is significantly associated with muscle deterioration, with older adults experiencing changes in tongue and suprahyoid muscles related to swallowing function. Tailored interventions are necessary for specific muscles to prevent dysphagia associated with aging.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Kristina A. Sharlo, Irina D. Lvova, Sergey A. Tyganov, Ksenia V. Sergeeva, Vitaly Y. Kalashnikov, Ekaterina P. Kalashnikova, Timur M. Mirzoev, Grigoriy R. Kalamkarov, Tatiana F. Shevchenko, Boris S. Shenkman
Summary: Skeletal muscle disuse leads to pathological muscle activity and slow-to-fast fiber-type transformation. Prochlorperazine blocks this transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ting-Ting Zhang, Qing-Qing Lei, Jie He, Xin Guan, Xin Zhang, Ying Huang, Zi-Yue Zhou, Rui-Xin Fan, Ting Wang, Chen-Xi Li, Jin-Yan Shang, Zhuo-Miao Lin, Wan-Li Peng, Li-Kai Xia, Yu-Ling He, Chuan-Ying Hong, Jing-Song Ou, Rui-Ping Pang, Xiao-Ping Fan, Hui Huang, Jia-Guo Zhou
Summary: This study reveals that Best3 mutation, which mainly acts in blood vessels, leads to aortic dissection by regulating the degradation of MEKK2/3, controlling smooth muscle cell phenotypic switch, and maintaining the structural integrity of the aorta. This provides a new therapeutic target for the treatment of aortic dissection.
Article
Geriatrics & Gerontology
T. Mori, Hidetaka Wakabayashi, N. Ogawa, I. Fujishima, F. Oshima, M. Itoda, K. Kunieda, T. Shigematsu, S. Nishioka, H. Tohara, M. Yamada, S. Ogawa
Summary: The study found that geniohyoid muscle mass is an independent explanatory factor for maximum tongue pressure and tongue muscle mass.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Clinical Neurology
Xuesong Luo, Hilda Victoria Gutierrez Pulido, Seward Brian Rutkove, Benjamin Sanchez
Summary: A novel technology was used to assess the volume conduction properties (VCPs) of the tongue in healthy individuals, revealing higher conductivities in the longitudinal direction compared to the transverse direction at different frequencies. These findings suggest that VCPs could serve as valuable data for diagnostic purposes and treatment monitoring.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Renata R. Bruno, Fernanda C. Rosa, Paula C. Nahas, Flavia M. S. de Branco, Erick P. de Oliveira
Summary: Aging is associated with decreased muscle strength and increased reactive oxygen species. This cross-sectional study found that serum levels of alpha-carotene were positively associated with muscle strength in older adults, while other antioxidants were not. This suggests that alpha-carotene may have a beneficial effect on muscle strength in aging individuals.
Article
Geriatrics & Gerontology
William Evans, Mahalakshmi Shankaran, Edna Nyangau, Tyler Field, Hussein Mohammed, Robert Wolfe, Scott Schutzler, Marc Hellerstein
Summary: This study examined the effects of Fortetropin supplementation on muscle protein FSR in older individuals, finding that Fortetropin increased FSR compared to a placebo group. The difference in FSR between Fortetropin and placebo was 18% and affected multiple gene ontologies, suggesting that Fortetropin supplementation may be effective for promoting muscle protein synthesis in older populations.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Physiology
Matthew J. Fogarty, Gary C. Sieck
Summary: The study focused on the mechanical and fatigue properties of tongue muscles in 6-month-old Fischer 344 rats, finding that different tongue muscles exhibit variations in strength and fatigue, with the genioglossus muscle being more fatigue resistant. This research provides insights into the force, fatigue, and fiber type-specific properties of individual tongue musculature, offering a useful muscular readout for conditions involving motor control dysfunction or tongue weakness.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Correction
Biochemistry & Molecular Biology
R. J. Sullivan, K. Flaherty
Summary: A correction to the paper has been published.
Article
Geriatrics & Gerontology
Sebastiaan Dalle, Jolan Dupont, Lenore Dedeyne, Sabine Verschueren, Jos Tournoy, Evelien Gielen, Katrien Koppo
Summary: This study compared the protein expression profiles between older adults with preserved and low muscle strength, and found differences in catabolic, mitochondrial, stress-related, and myogenic pathways. The increased stress factors in the low muscle strength group may reflect the deterioration of tissue homeostasis, while the upregulation of myogenic markers in this group may be an attempt to compensate for the gradual loss in muscle quantity and quality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Mathematical & Computational Biology
Eryk Kropiwnicki, John E. Evangelista, Daniel J. Stein, Daniel J. B. Clarke, Alexander Lachmann, Maxim Kuleshov, Minji Jeon, Kathleen M. Jagodnik, Avi Ma'ayan
Summary: By analyzing the molecular and structural similarities of drugs and small molecules, machine learning techniques can help identify drug repurposing opportunities and predict potential side effects. Databases and search engines provide rich knowledge in the field of pharmacology, supporting applications in systems pharmacology.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2021)
Article
Biochemical Research Methods
Qiong Wu, Tianzhou Ma, Qingzhi Liu, Donald K. Milton, Yuan Zhang, Shuo Chen
Summary: The study introduces a new computational package for extracting interconnected communities from gene co-expression networks, providing a more flexible approach to understanding gene regulatory mechanisms. By developing efficient algorithms and leveraging advanced graph norm shrinkage, the method demonstrates significant advantages in simulation studies. The approach is validated by applying it to RNA-seq data from a cancer study, identifying key biological pathways related to tumor cells' immune evasion mechanisms.
Article
Biochemistry & Molecular Biology
Sandra Magalhaes, Idalia Almeida, Filipa Martins, Fatima Camoes, Ana R. Soares, Brian J. Goodfellow, Sandra Rebelo, Alexandra Nunes
Summary: The use of FTIR spectroscopy in studying age-related changes in mouse muscle tissues revealed significant alterations in protein secondary structures with aging, including decreased oligomeric structures and increased intermolecular beta-sheet structures in cardiac muscle. Despite the inability to identify specific proteins responsible for these changes, the study sheds light on the potential of FTIR in monitoring the aging process and discovering age-specific spectroscopic signatures.