Article
Materials Science, Multidisciplinary
Qiaoyun Gong, Yue Zhao, Tianwei Qian, Haiyan Wang, Zuhao Li
Summary: Functionalized hydrogels show great potential in ophthalmic applications. This review summarizes the various functionalized hydrogels for different eye diseases and introduces advanced research progress in ophthalmic applications. Engineered hydrogels are expected to become powerful tools for the treatment of ocular diseases in the future.
MATERIALS & DESIGN
(2022)
Article
Multidisciplinary Sciences
D. Chan, G. J. Won, A. T. Read, C. R. Ethier, E. Thackaberry, S. R. Crowell, H. Booler, V Bantseev, J. M. Sivak
Summary: This study investigates the movement of particles in the eye during intravitreal drug delivery. Using an organotypic perfusion strategy and experiments in pig and human eyes, it is found that the aggregate particle size plays a crucial role in determining their movement within the eye.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Pharmacology & Pharmacy
Amir Sadeghi, Marika Ruponen, Jooseppi Puranen, Shoupeng Cao, Roxane Ridolfo, Shirin Tavakoli, Elisa Toropainen, Tatu Lajunen, Veli-Pekka Ranta, Jan van Hest, Arto Urtti
Summary: This study investigates the pharmacokinetics of nanomaterials in the eyes of rats and rabbits. The impact of particle size and shape on ocular distribution and elimination was examined using various imaging techniques. The results show that differently sized particles have different retention times and elimination rates, suggesting that factors other than size also play a role in their kinetics. The study also demonstrates the importance of synchronized particle retention and drug release rate for efficient drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Changzhao Jiang, Xiumei Jiang, Xiumin Wang, Jiaxu Shen, Mengjie Zhang, Leilei Jiang, Rui Ma, Tingting Gan, Yingbiao Gong, Jincui Ye, Wenyan Gao
Summary: This study successfully established a transdermal iontophoresis delivery system for terazosin hydrochloride and investigated the impact of factors such as current intensity, TEH concentration, and pH on its penetration rate. Results showed that IDDS-TEH had a higher blood concentration and antihypertensive effects compared to passive diffusion. Further clinical studies are needed to develop a therapeutically useful protocol based on these findings.
Article
Pharmacology & Pharmacy
Laura Gisela Gonzalez Iglesias, Siwar Messaoudi, Yogeshvar N. Kalia
Summary: This study demonstrated that transscleral iontophoresis can enhance the delivery of cytochrome c to the posterior segment of the eye. Factors such as cytochrome c concentration and current density were found to influence the iontophoretic delivery. The findings highlight the potential of transscleral iontophoresis as a delivery method for ocular drugs.
Article
Pharmacology & Pharmacy
Anna Balasso, Astrid Subrizi, Stefano Salmaso, Francesca Mastrotto, Mariangela Garofalo, Miao Tang, Mei Chen, Heping Xu, Arto Urtti, Paolo Caliceti
Summary: The treatment of posterior segment disorders of the eye requires strategies to achieve prolonged drug effects. Innovative colloidal delivery systems can deliver drugs to the retina and prolong their intravitreal permanence. Bioconjugates are taken up by retinal RPE cells and show promise for long-acting intravitreal injectable drugs.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
David Bussing, Yingyi Li, Leiming Guo, Ashwni Verma, Jack M. Sullivan, Dhaval K. Shah
Summary: Mice are rarely used in pharmacokinetic (PK) studies of ocular therapeutics due to the small size of their eyes and challenges in drug administration, tissue collection, and analysis of drug concentrations. Therefore, ocular PK of protein therapeutics in mouse eye following intravitreal (IVT) administration is not known. This study investigated the PK of 4 different size non-binding protein therapeutics in various ocular tissues of mice following IVT administration. The findings provide valuable insights for drug discovery and development studies of protein therapeutics for ophthalmic indications in mice.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Polymer Science
Dong Wei, Ning Pu, Si-Yu Li, Na Zhao, Zong-Ming Song, Ye Tao
Summary: This article mainly discusses the application of hydrogel iontophoresis in ophthalmologic practice. Hydrogels, with soft material and excellent properties, are used to deliver drugs into ocular tissue effectively. The direct contact between hydrogels and the eye during iontophoresis reduces mechanical damage to the ocular surface and enhances the efficiency of drug delivery.
Article
Chemistry, Multidisciplinary
Razina Z. Seeni, Mengjia Zheng, Daniel Chin Shiuan Lio, Christian Wiraja, Mohammad Firdaus Bin Mohd Yusoff, William Teck Yeow Koh, Yuchun Liu, Bee Tin Goh, Chenjie Xu
Summary: Microneedles have emerged as a minimally invasive alternative for local anesthesia delivery in dental procedures, reducing pain and anxiety associated with traditional needle injections. The development of a conductive microneedle array in combination with iontophoresis technique has shown to effectively penetrate oral mucosa and underlying bone tissue, providing a dual-role of creating micro-conduits and reducing tissue resistance for drug delivery.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Vijayabhaskarreddy Junnuthula, Amir Sadeghi Boroujeni, Shoupeng Cao, Shirin Tavakoli, Roxane Ridolfo, Elisa Toropainen, Marika Ruponen, Jan C. M. van Hest, Arto Urtti
Summary: This study synthesized and characterized block copolymers that self-assembled into polymersomes and polymeric micelles, which showed stability and diffusibility in the vitreous and no cellular toxicity. Pharmacokinetic evaluation in rabbits showed prolonged half-lives and retention of these nanocarriers in the vitreous, making them promising for controlled and site-specific drug delivery in the posterior eye segment.
Article
Pharmacology & Pharmacy
Christian J. F. Bertens, Marlies Gijs, Aylvin A. J. Dias, Frank J. H. M. van den Biggelaar, Arkasubhra Ghosh, Swaminathan Sethu, Rudy M. M. A. Nuijts
Summary: The study showed that the ketorolac-loaded ocular coil provided sustained drug release in the eye, and demonstrated a similar therapeutic benefit in suppressing post-operative inflammation as compared to eye drops.
Article
Pharmacology & Pharmacy
Dong Wei, Ning Pu, Si-Yu Li, Yan-Ge Wang, Ye Tao
Summary: Delivery of drugs to specific locations of ocular lesions is a challenging task in ophthalmic practice. Iontophoresis, a noninvasive technology, has been developed to enhance drug penetration using a small electric current. This technique has shown promising results in delivering various drugs to treat different eye diseases.
Review
Pharmacology & Pharmacy
Dmitriy Berillo, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, Arman Saparov
Summary: Despite the conventional use of oral and intravenous routes for drug administration, they face limitations such as reduced bioavailability and invasiveness. Therefore, alternative delivery routes and modifications to drug formulations using stimuli-responsive polymers can improve drug release and bioavailability.
Article
Materials Science, Multidisciplinary
Goeen Jeong, Hyung-Seop Han, Hojeong Jeon, Yu-Chan Kim, Ho Won Jang, Myoung-Ryul Ok
Summary: Although metallic microneedles (MNs) and iontophoresis have been extensively studied, the use of biodegradable metals for transdermal drug delivery has not received much attention. In this study, Mg was employed as a promising candidate for an MN electrode due to its metallic properties and the hydrogen gas generated during Mg corrosion. The Mg MN electrode was fabricated using a nanosecond laser, and the hydrogen gas produced during iontophoresis was measured at various applied potentials. The results demonstrate an optimal potential range for iontophoresis based on the combined effect of enhanced drug diffusion and impediment from hydrogen generation.
METALS AND MATERIALS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Kamchai Saepang, S. Kevin Li, Doungdaw Chantasart
Summary: The study explored the potential of skin microchannels created by polymer microneedle patches for enhancing transdermal drug delivery of pramipexole dihydrochloride. Results showed that drug-loaded dissolving microneedle (DMN) patches greatly improved PXCl transdermal delivery compared to conventional methods, while hydrogel-forming microneedle (HGMN) patches provided more sustained drug delivery. Electromigration was identified as the main mechanism for iontophoresis of PXCl through microchannels, with HGMN patches showing greater flux enhancement than DMN patches. The study indicates the potential application of microneedle patches, either alone or in combination with iontophoresis, as an alternative method for PXCl administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Terri D. LaCount, Qian Zhang, Jinsong Hao, Priyanka Ghosh, Sam G. Raney, Arjang Talattof, Gerald B. Kasting, S. Kevin Li
Article
Ophthalmology
Sarah Molokhia, Kongnara Papangkorn, Charlotte Butler, John W. Higuchi, Balbir Brar, Balamurali Ambati, S. Kevin Li, William Higuchi
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Pharmacology & Pharmacy
Terri D. La Count, Qian Zhang, Michael Murawsky, Jinsong Hao, Priyanka Ghosh, Kaushalkumar Dave, Sam G. Raney, Arjang Talattof, Gerald B. Kasting, S. Kevin Li
Article
Chemistry, Medicinal
Qian Zhang, Michael Murawsky, Terri D. LaCount, Jinsong Hao, Priyanka Ghosh, Sam G. Raney, Gerald B. Kasting, S. Kevin Li
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Kamchai Saepang, S. Kevin Li, Doungdaw Chantasart
Summary: This study evaluated the effect of decreasing the formulation pH to increase the positive charges of pramipexole dihydrochloride (PXCl) on its iontophoretic transport across skin. The results showed that the decrease in PXCl delivery at higher valence at pH 3 was mainly due to pH-dependent selectivity of PX ion permeation across the skin and not electroosmosis. Skin permselectivity is a significant factor for iontophoretic transport of PXCl, and reducing formulation pH to increase the positive charges on PX ions did not enhance PXCl delivery.
PHARMACEUTICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kamchai Saepang, S. Kevin Li, Doungdaw Chantasart
Summary: The study explored the potential of skin microchannels created by polymer microneedle patches for enhancing transdermal drug delivery of pramipexole dihydrochloride. Results showed that drug-loaded dissolving microneedle (DMN) patches greatly improved PXCl transdermal delivery compared to conventional methods, while hydrogel-forming microneedle (HGMN) patches provided more sustained drug delivery. Electromigration was identified as the main mechanism for iontophoresis of PXCl through microchannels, with HGMN patches showing greater flux enhancement than DMN patches. The study indicates the potential application of microneedle patches, either alone or in combination with iontophoresis, as an alternative method for PXCl administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Kamchai Saepang, S. Kevin Li, Doungdaw Chantasart
Summary: This study examined the effect of PDC iontophoresis on transdermal delivery of PXCl and found that while PDC iontophoresis can modulate the permeation profile of PXCl, it does not enhance iontophoretic transport compared to continuous DC iontophoresis.
PHARMACEUTICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Apipa Wanasathop, Priya B. Patel, Hyojin A. Choi, S. Kevin Li
Summary: An in-depth review of permeability data of porcine buccal mucosa revealed significant variability, with correlations observed between permeability coefficients and factors such as octanol/water partition coefficients, molecular weight, and effective pore radius for the buccal membrane barrier.
Article
Pharmacology & Pharmacy
Apipa Wanasathop, Michael Murawsky, S. Kevin Li
Summary: This study evaluated a 3D-printed small volume flow-through dissolution chamber system, modified for biorelevant and dose-discriminating testing of periodontal drug products. The results showed that, except for Atridox, there were no significant differences in the drug release profiles in vitro and in vivo. The drug release data demonstrated dose-discriminating ability at specific time points.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Biomaterials
Thomas Waterkotte, Xingyu He, Apipa Wanasathop, S. Kevin Li, Yoonjee C. Park
Summary: The study suggests that monoclonal antibodies can be released from a porous PCL capsule without being affected by polymer degradation, potentially lasting for up to 6 months. Accelerated degradation can determine long-term release kinetics within 14 days.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Medicinal
Apipa Wanasathop, Cheng Zhong, Patcharawan Nimmansophon, Michael Murawsky, S. Kevin Li
Summary: Gingiva, or gum, is a protective barrier for the tooth, preventing mechanical and bacterial damage. It is a target for topical drugs and understanding its barrier properties is important for effective drug delivery. A study using porcine gingiva as a model determined the permeability coefficients and observed a correlation between the Log P and Log Dow.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Patcharawan Nimmansophon, Apipa Wanasathop, S. Kevin Li
Summary: Membrane lateral transport has been studied in diffusion cells under edge effect and membrane blocking conditions. The simulations showed that edge effect could increase the flux across the membrane, especially with a thick membrane and small cell opening. Lateral diffusion within the membrane can mitigate the impact of membrane blocking by an object.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Toxicology
Cheng Zhong, Apipa Wanasathop, Zhanquan Shi, Kavssery Ananthapadmanabhan, S. Kevin Li
Summary: In vitro models can be used as alternatives to the Draize eye irritation test, but most alternative models lack quantitation to assess the effects of chemicals on the corneal barrier. This study investigates tissue electrical resistance as a sensitive in vitro testing approach to evaluate tissue alteration caused by chemicals in pharmaceutical and cosmetic products. The results show that the tested models can provide quantitative assessments of eye-irritating chemicals.
TOXICOLOGY IN VITRO
(2022)
Article
Pharmacology & Pharmacy
Apipa Wanasathop, Hyojin Alex Choi, Patcharawan Nimmansophon, Michael Murawsky, Deepak G. Krishnan, S. Kevin Li
Summary: The permeability of human gingiva was evaluated and compared with that of porcine gingiva. Fresh human and porcine gingiva showed similarities in permeability coefficients and octanol-water distribution coefficients. Porcine gingiva had lower permeability than human gingiva and the permeability increased significantly after freezing. Frozen human cadaver tissue could not be used due to high permeability and sample-to-sample variabilities.
Article
Nanoscience & Nanotechnology
Xingyu He, Zheng Yuan, Samantha Gaeke, Winston W-Y Kao, S. Kevin Li, Daniel Miller, Basil Williams, Yoonjee C. Park
Summary: This study successfully developed a dosage-controllable drug delivery implant using light-activated liposomes and near-infrared laser. The drug release was controllable both in vitro and in vivo, with no abnormality observed in the eyes treated with the implant, suggesting the safety and potential efficacy of this system for long-term treatment of posterior eye diseases.
ACS APPLIED BIO MATERIALS
(2021)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)