Journal
EXPERIMENTAL EYE RESEARCH
Volume 88, Issue 2, Pages 314-322Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2008.07.014
Keywords
Na+/K+ ATPase alpha1; newt; retina; lens; regeneration
Categories
Funding
- Department of Zoology at Miami University
- Undergraduate Research Award
- NIH [EY10540]
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Adult newts are able to regenerate their retina and lens after injury or complete removal through transdifferentiation of the pigmented epithelial tissues of the eye. This process needs to be tightly controlled, and several different mechanisms are likely to be recruited for this function. The Na+/K+ ATPase is a transmembrane protein that establishes electrochemical gradients through the transport of Na+ and K+ and has been implicated in the modulation of key cellular processes such as cell division, migration and adhesion. Even though it is expressed in all cells, its isoform composition varies with cell type and is tightly controlled during development and regeneration. In the present study we characterize the expression pattern of Na+/K+ ATPase alpha 1 in the adult newt eye and during the process of lens and retina regeneration. We show that this isoform is up-regulated in undifferentiated cells during transdifferentiation. Such change in composition could be one of the mechanisms that newt cells utilize to modulate this process. (C) 2008 Elsevier Ltd. All rights reserved.
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