Article
Ophthalmology
Jeremias G. Galletti, Kaitlin K. Scholand, Claudia M. Trujillo-Vargas, Wolfgang Haap, Tiago Santos-Ferreira, Christoph Ullmer, Zhiyuan Yu, Cintia S. de Paiva
Summary: This study investigated the effects of cathepsin S inhibition on age-related dry eye disease. The results showed that inhibiting cathepsin S or lacking the cathepsin S gene improved conjunctival goblet cell density and cornea mechanosensitivity in aged mice. Further studies are needed to investigate the role of cathepsin S during aging.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Jing-Yi Zhu, Xi Zhang, Xiao Zheng, Lin-Lin Luo, Cheng-Yi Mao, Sen Lin, Jian Ye
Summary: This study provides evidence that HSV-1 infection can induce DES in irf3-deficient mice in the HGs and LGs, potentially introducing a novel target for DES treatment.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Swati Singh, Swapna S. Shanbhag, Sayan Basu
Summary: The study aimed to investigate the morphological features of the palpebral lobe of the main lacrimal gland in normal and dry eyes, specifically in patients with cicatrising conjunctivitis (CC), evaporative dry eyes (EDE), and Sjogren's syndrome (SS). Results showed that while the palpebral lobes in normal and EDE group were similar, those in CC and SS groups exhibited significant distortions in size, shape, and presence of scarring and conjunctival vessels.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, Research & Experimental
Chae Eun Kim, Young Jin Kim, Moon Won Hwang, Young-Joon Park, Jaewook Yang
Summary: This study showed that CVM was as effective as commercial drugs in improving tear production, corneal condition, and epithelial cell density in a murine dry eye model, indicating its potential as a treatment option for dry eye syndrome.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Ophthalmology
Pasquale Aragona, Giuseppe Giannaccare, Rita Mencucci, Pierangela Rubino, Emilia Cantera, Maurizio Rolando
Summary: Dry eye disease is a growing public health concern with significant socio-economic impact, characterized by tear film instability and ocular surface inflammation. Treatment should focus on restoring ocular surface homeostasis while considering factors such as epithelial damage and nerve damage.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Cara Sullivan, Jun Lee, William Bushey, Danielle Demers, Samantha Dinsdale, Katy Lowe, Jessica Olmeda, Ian D. Meng
Summary: This study investigated corneal innervation, ongoing pain, and alterations in corneal afferent phenotypes in a mouse model of severe aqueous tear deficiency. The results showed that dry eye-induced damage to corneal afferents led to corneal epithelial damage and ongoing ocular irritation. The corneal neurons underwent a regenerative process after injury, which was more significant in male animals. Additionally, dry eye also caused alterations in IB4-positive neurons, which may enhance neuroprotective mechanisms.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Neal E. Mecum, Rachel Russell, Jun Lee, Cara Sullivan, Ian D. Meng
Summary: The study investigated the role of Nav1.8 expressing corneal afferent neurons in ongoing pain in dry eye induced by lacrimal gland excision. Results showed that inhibition of these neurons could be a potential strategy for treating ongoing dry eye-induced pain.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tatsuma Kishimoto, Waka Ishida, Isana Nakajima, Ken Fukuda, Kenji Yamashiro
Summary: Dry eye disease (DED) and allergic conjunctivitis have interactions and can exacerbate each other in mice, leading to ocular surface epithelial damage and aggravated allergic signs and symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Ophthalmology
Ying Bai, Kaier Zhang, Xin Cao, Peng Chen
Summary: Dry eye is closely related to aging, leading to changes in the structure and function of the lacrimal gland and reduced tear secretion. Aquaporins have been identified as important factors in the lacrimal gland, potentially involved in exocrine fluid production and transport.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Ophthalmology
Koji Kitazawa, Takenori Inotmata, Kendric Shih, Jun-Wei B. Hughes, Niha Bozza, Yasufumi Tomioka, Kohsaku Numa, Norihiko Yokoi, Judith Campisi, Reza Dana, Chie Sotozono
Summary: The study found that with aging, changes in the ocular surface microenvironment can lead to the development of DED. The prevalence of DED is relatively higher in the elderly, with aging potentially having negative effects on the ocular surface epithelium, lacrimal gland, and meibomian gland.
Article
Medicine, General & Internal
Matias Soifer, Nadim S. Azar, Hazem M. Mousa, Victor L. Perez
Summary: Ocular surface inflammatory disorders (OSID) are inflammatory reactions in the ocular adnexal connective tissues caused by systemic disorders, resulting in inflammatory dry eye. The lack of available biomarkers for detecting and quantifying inflammation in the conjunctiva and lacrimal gland is a major limitation in managing these conditions. OSID and dry eye syndrome involve different immune cells and understanding the potential role of inflammation and immune phenotype in ocular tissues is crucial.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Yong Woo Ji, Hyun Goo Kang, Jong Suk Song, Ji Won Jun, Kyusun Han, Tae-im Kim, Kyoung Yul Seo, Hyung Keun Lee
Summary: The study found an upregulation of dopamine receptors DR1 and DR2 in the lacrimal glands of mice induced with dry eye, with the inhibition of DR2 exacerbating inflammatory conditions.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Induvahi Veernala, Jilu Jaffet, Jasmin Fried, Sonja Mertsch, Stefan Schrader, Sayan Basu, Geeta K. Vemuganti, Vivek Singh
Summary: This review discusses the therapeutic mechanisms and regenerative strategies for lacrimal gland tissue regeneration, focusing on aqueous deficiency dry eye disease (ADDE) caused by lacrimal gland dysfunction and future treatment strategies. Key findings from cell and tissue-based regenerative therapy are summarized, along with the limitations and possible clinical applications. The current issues and unmet needs of cell-based therapies for complete lacrimal gland tissue regeneration are also discussed.
Review
Food Science & Technology
Milosz Caban, Katarzyna Owczarek, Katarzyna Chojnacka, Urszula Lewandowska
Summary: Plant polyphenols and polyphenol-rich extracts have a wide range of properties, such as anti-cancer, anti-inflammatory, anti-oxidative, and pro-apoptotic effects, which can be used to treat dry eye disease. Long-term use of synthetic drugs and artificial tears may cause side effects.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Ophthalmology
Yu Chen, Jiheng Pu, Xinda Li, Lili Lian, Chaoxiang Ge, Zuimeng Liu, Weizhuo Wang, Ling Hou, Wei Chen, Jinyang Li
Summary: The deficiency of AIM2 can alleviate ocular surface damage and lacrimal gland inflammation in the pathogenesis of DED. AIM2 deficiency also suppresses macrophage infiltration and inflammatory cytokine production.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Hematology
Leah N. Cueni, Lu Chen, Hui Zhang, Daniela Marino, Reto Huggenberger, Annamari Alitalo, Roberta Bianchi, Michael Detmar
Article
Oncology
Austin T. Thiel, Peter Blessington, Tao Zou, Danielle Feather, Xinjiang Wu, Jizhou Yan, Hui Zhang, Zuguo Liu, Patricia Ernst, Gary A. Koretzky, Xianxin Hua
Letter
Cell Biology
Don Yuen, Xiufeng Wu, Alex C. Kwan, Jeffrey LeDue, Hui Zhang, Tatiana Ecoiffier, Bronislaw Pytowski, Lu Chen
Article
Biochemistry & Molecular Biology
J. Yan, Y. Yang, H. Zhang, C. King, H-M Kan, Y. Cai, C-X Yuan, G. S. Bloom, X. Hua
Article
Ophthalmology
Hui Zhang, Sammy Grimaldo, Don Yuen, Lu Chen
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2011)
Article
Medicine, General & Internal
Zhang Hui, Liu Zu-guo, Hua Xian-xin
CHINESE MEDICAL JOURNAL
(2011)
Article
Immunology
S. Grimaldo, M. Garcia, H. Zhang, L. Chen
Article
Ophthalmology
Shi-Qi Ling, Dao-Man Xiang, Shi-Yi Xiao, Hui Zhang
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2009)
Article
Ophthalmology
H Zhang, M Hara, K Seki, K Fukuda, J Nishida
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2005)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)