Article
Cardiac & Cardiovascular Systems
Kazutoshi Hirose, Koki Nakanishi, Masao Daimon, Naoko Sawada, Yuriko Yoshida, Kentaro Iwama, Yuko Yamamoto, Jumpei Ishiwata, Megumi Hirokawa, Katsuhiro Koyama, Tomoko Nakao, Hiroyuki Morita, Marco R. Di Tullio, Shunichi Homma, Issei Komuro
Summary: Insulin resistance is independently associated with subclinical left ventricular dysfunction in the general population, especially in individuals with normal weight. This association persists even after adjustment for waist circumference as a marker of abdominal adiposity.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Xi Chen, Enrique Maldonado, Ralph A. DeFronzo, Devjit Tripathy
Summary: The study revealed that there is a relationship between plasma glucagon levels and insulin sensitivity and insulin secretion in obese individuals. As glucose intolerance worsens, the insulin-mediated suppression of glucagon secretion is impaired, which corresponds to the severity of insulin resistance and beta-cell dysfunction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Xue Tian, Yingting Zuo, Shuohua Chen, Xia Meng, Pan Chen, Yongjun Wang, Shouling Wu, Yanxia Luo, Anxin Wang
Summary: This study identified five distinct trajectories of TyG index in normal-weight adults and found that these trajectories were differently associated with the risk of cardiovascular disease. The high-stable pattern showed the highest risk of CVD.
AMERICAN HEART JOURNAL
(2022)
Article
Endocrinology & Metabolism
Kai-Yue Han, Jianing Gu, Zhangsheng Wang, Jie Liu, Su Zou, Chen-Xi Yang, Dan Liu, Yingjia Xu
Summary: The study found a significant association between METS-IR levels and pre-hypertension or hypertension in normoglycemia individuals in Japan. For each 1 unit increase in METS-IR, there was a 7% increase in pre-hypertension prevalence and a 13% increase in hypertension prevalence. These findings suggest that METS-IR may be a useful monitoring indicator for developing primary prevention and management strategies for hypertension in the future.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Sport Sciences
Cristina-Ioana Pirscoveanu, Peter Dam, August Brandi, Malthe Bilgram, Anderson Souza Oliveira
Summary: The study found that fatigued runners had significantly greater peak impact sounds during normal running compared to silent running, without changes in force parameters. Furthermore, peak impact sounds, IPF, VILR, and VALR during normal running were greater than during silent running, regardless of fatigue status.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Khaoula Errafii, Said Boujraf, Mohamed Chikri
Summary: Understanding the role of white adipose tissue (WAT) in metabolic syndrome, including obesity and type 2 diabetes (T2D), is important. Insulin resistance plays a key role in the development of T2D. The comparison of WAT differences between obese diabetics and obese individuals with normal glucose tolerance and insulin resistance can provide insights into the molecular pathways underlying the development of obesity-related T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Christopher E. Shannon, Aurora Merovci, Marcel Fourcaudot, Devjit Tripathy, Muhammad Abdul-Ghani, Hu Wang, Xianlin Han, Luke Norton, Ralph A. DeFronzo
Summary: This study demonstrates that the major lipid pools in skeletal muscle are not affected by increased glucose availability, suggesting that glucotoxicity and lipotoxicity promote insulin resistance through distinct mechanistic pathways.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Huizhen Sun, Anyong Zhang, Yanchun Gong, Wei Sun, Baiyi Yan, Shuihong Lei, Li-Hua Yao
Summary: Cordycepin promotes insulin synthesis and secretion, possibly through increased expression of insulin-related genes and proteins, elevated ATP levels, and higher Ca2+ concentrations. In addition, Cordycepin protects pancreatic beta cells from oxidative damage, improving their viability and insulin synthesis/secretion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Myriam Beaudry, Simon Bissonnette, Valerie Lamantia, Marie Devaux, May Faraj
Summary: Sex-specific models incorporating anthropometric and lipoprotein-related parameters allowed better prediction of insulin secretion and sensitivity in subjects with overweight or obesity than current indices that rely on glucose and insulin alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Francesco Ferrara, Valentina Capone, Filippo Cademartiri, Olga Vriz, Rosangela Cocchia, Brigida Ranieri, Monica Franzese, Rossana Castaldo, Antonello D'Andrea, Rodolfo Citro, Salvatore Chianese, Roberto Annunziata, Flavio Marullo, Mario Siniscalchi, Marianna Conte, Chiara Sepe, Renato Maramaldi, Salvatore Rega, Giuseppe Russo, Massimo Majolo, Eliana Raiola, Andrea Salzano, Ciro Mauro, Bruno Trimarco, Raffaele Izzo, Eduardo Bossone
Summary: This study established normal non-invasive myocardial mechano-energetic efficiency (MEE) and indexed MEE reference values, which can improve the global assessment of left ventricular cardiac mechanics and serve as a reference to identify phenotypes at high risk of cardiovascular events.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Hematology
Jing-gang Xia, Bowen Li, Hao Zhang, Qin-xue Li, Sin Man Lam, Chun-lin Yin, He Tian, Guanghou Shui
Summary: This study used quantitative metabolomics to investigate the metabolic differences in acute myocardial infarction (AMI) patients with and without diabetes. The findings revealed that diabetes-AMI patients had more severe metabolic dysregulation, involving multiple pathways such as carbohydrate metabolism, lipid metabolism, glycolysis, tricarboxylic acid cycle, and amino acid metabolism. The key functional metabolites N-lactoyl-phenylalanine and lysophosphatidylcholines were identified, which were associated with mitochondrial dysfunction, glucose utilization, and inflammation, suggesting their potential as therapeutic targets for diabetes-AMI.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kenichi Tanaka, Yosuke Okada, Keiichi Torimoto, Kosuke Nishio, Manabu Narisawa, Yoshiya Tanaka
Summary: This study determined the effects of hypoglycemic stimulation on vascular endothelial function in non-diabetic patients using reactive hyperemia peripheral arterial tonometry (RH-PAT). The results showed that hypoglycemic stimulation altered vascular endothelial function, which correlated with increases in catecholamine levels during hypoglycemia.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yan Li, Fusheng Wang, Chenguang Huang, Jianting Ren, Donghong Wang, Jie Kong, Tao Liu, Laohu Long
Summary: In this paper, it is demonstrated that pulse current can effectively reduce delamination damage and residual deformation in 3D orthogonal woven composites, improving their mechanical properties and damage tolerance. A damage reduction strategy is proposed by combining structural and electromagnetic properties, and an experimental platform is developed to investigate the effects of pulse current and impact force on woven composites. Experimental results show that pulse current can effectively reduce delamination damage and residual deformation. A multi-field coupled damage model is developed to analyze the evolutions of temperature, current, and damage, providing insights into the mechanism of damage reduction and a potential approach for improving damage tolerance of these composites.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Soheir M. Kasem, Ghada Mohamed Saied, Abdel Nasser M. A. Hegazy, Mahmoud Abdelsabour
Summary: The study revealed that acute insulin resistance was prevalent in non-diabetic patients with STEMI and was independently associated with impaired myocardial blush, pulmonary edema, and impaired left ventricular systolic function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Camila Pires Mendes, Barbara Graziela Postal, Marisa Jadna Silva Frederico, Rui Goncalves Marques Elias, Veronica Aiceles de Medeiros Pinto, Cristiane da Fonte Ramos, Patricia Devantier Neuenfeldt, Ricardo Jose Nunes, Fatima Regina Mena Barreto Silva
Summary: A new library of hybrid compounds was developed to optimize the pharmacological activities of two drugs for the treatment of type 2 diabetes, potentially minimizing adverse effects. Among the screened compounds, PTEBS was identified to effectively regulate glucose and lipid homeostasis.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Kei Mizuno, Hiroaki Haga, Kazuo Okumoto, Kyoko Hoshikawa, Tomohiro Katsumi, Taketo Nishina, Takafumi Saito, Hideki Katagiri, Yoshiyuki Ueno
Summary: Autonomic nerve fibers in the liver play a crucial role in regulating blood flow, bile secretion, and hepatic metabolism to maintain systemic homeostasis. Chronic hepatitis, especially viral hepatitis, and advanced liver fibrosis were associated with significantly lower nerve fiber ratios in the liver. However, antiviral treatment for HCV showed recovery of nerve fiber ratios along with improvement of liver fibrosis.
Article
Gastroenterology & Hepatology
Hitoshi Yoshiji, Yoshiyuki Ueno, Masayuki Kurosaki, Takuji Torimura, Etsuro Hatano, Hiroshi Yatsuhashi, Koichiro Yamakado
Summary: Thrombocytopenia is common in patients with chronic liver disease, who often require invasive procedures with a risk of bleeding. Platelet transfusion and thrombopoietin receptor agonists (TPORAs) are two options to increase platelet counts in these patients. Treatment algorithms in different countries vary, with the choice of treatment mainly dependent on the physician's judgment and experience. A more guidance-oriented treatment algorithm is needed for optimal decision making in selecting TPORA therapy or platelet transfusion based on the latest evidence and clinical practice.
HEPATOLOGY RESEARCH
(2021)
Article
Peripheral Vascular Disease
Kai Huang, Taro Narumi, Yixuan Zhang, Qiang Li, Priya Murugesan, Yusi Wu, Norika Mengchia Liu, Hua Cai
Summary: Our study reveals a critical role of microRNA-192-5p in mediating NOX-dependent DHFR deficiency and AAA formation, and inhibition of which effectively attenuates the development of AAA. Since the sequences of mouse and human microRNA-192-5p are identical, microRNA-192-5p inhibitors may offer a potential therapeutic option for AAA treatment.
Article
Endocrinology & Metabolism
Makoto Saegusa, Yumi Matsuda, Tsuneo Konta, Takafumi Saitoh, Kaori Sakurada, Midori Furuse, Chisaki Uno, Takamasa Kayama, Yoshiyuki Ueno
Summary: This study found that serum cholinesterase (ChE) levels are independent predictors of all-cause mortality in a community-based population, while serum albumin (Alb) levels do not have this effect.
ANNALS OF NUTRITION AND METABOLISM
(2022)
Review
Gastroenterology & Hepatology
Tomohiro Katsumi, Yoshiyuki Ueno
Summary: Autoimmune hepatitis (AIH) is a chronic liver disease that mainly affects hepatocytes. Recent epidemiological studies in Asia have revealed regional characteristics of AIH, with type 1 being predominant in East Asia and type 2 being as frequent as in Europe and the USA in South Asia. The prevalence of AIH is increasing worldwide, and early diagnosis and treatment can improve the situation in Asia.
LIVER INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Tetsuya Ishizawa, Naohiko Makino, Yasuharu Kakizaki, Akiko Matsuda, Yoshihide Toyokawa, Shun Ooyama, Masaru Tanaka, Yoshiyuki Ueno
Summary: This study demonstrated the biosafety of PMEA-CSEMS in normal porcine bile ducts, showing no significant inflammatory response and resistance to sludge. Additionally, no abnormalities were observed in serological and histological analyses.
Editorial Material
Cardiac & Cardiovascular Systems
Taro Narumi, Yoshihisa Naruse, Takeru Isogaki, Yuichiro Maekawa
Article
Multidisciplinary Sciences
Takenori Ikoma, Yoshihisa Naruse, Yutaro Kaneko, Tomoaki Sakakibara, Taro Narumi, Makoto Sano, Satoshi Mogi, Kenichiro Suwa, Hayato Ohtani, Masao Saotome, Tsuyoshi Urushida, Yuichiro Maekawa
Summary: Age, female sex, dilated cardiomyopathy, hypertrophic cardiomyopathy, persistent AF and larger LA volume may predict the presence of low-voltage zones.
Article
Medicine, General & Internal
Hideto Kawaratani, Yasuteru Kondo, Ryoji Tatsumi, Naoto Kawabe, Norikazu Tanabe, Akira Sakamaki, Kazuo Okumoto, Yoshihito Uchida, Kei Endo, Takumi Kawaguchi, Tsunekazu Oikawa, Yoji Ishizu, Shuhei Hige, Taro Takami, Shuji Terai, Yoshiyuki Ueno, Satoshi Mochida, Yasuhiro Takikawa, Takuji Torimura, Tomokazu Matsuura, Masatoshi Ishigami, Kazuhiko Koike, Hitoshi Yoshiji
Summary: This study found that long-term treatment with rifaximin is effective and safe for patients with hepatic encephalopathy. Ammonia levels significantly improved after 3 months of treatment and remained improved until 12 months. There were no serious adverse events reported, and the incidence of overt hepatic encephalopathy was low.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Taro Narumi, Yoshihisa Naruse, Yutaro Kaneko, Tomoaki Sakakibara, Makoto Sano, Satoshi Mogi, Kenichiro Suwa, Hayato Ohtani, Tsuyoshi Urushida, Masao Saotome, Yuichiro Maekawa
Summary: This study investigates the possibility of obtaining individualised left anterior oblique (LAO) angle using preprocedural electrocardiographic parameters and its impact on the success rate of right ventricular (RV) lead implantation into the interventricular septum. The results show that the individualised LAO angle derived from the preoperative ECG ORS axis is a new useful and simple method for RV lead implantation into the interventricular septum, significantly improving the success rate.
Letter
Gastroenterology & Hepatology
Y. Sasaki, Y. Abe, S. Nishise, Y. Ueno
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Kaori Sakurada, Tsuneo Konta, Narumi Murakami, Naoko Kosugi, Takafumi Saito, Masafumi Watanabe, Kenichi Ishizawa, Yoshiyuki Ueno, Takamasa Kayama
Summary: This study found that lack of sexual interest may be a risk factor for all-cause mortality in Japanese males over 40 years old.
Review
Medicine, General & Internal
Yu Sasaki, Yasuhiko Abe, Naoko Mizumoto, Eiki Nomura, Yoshiyuki Ueno
Summary: Eosinophilic gastroenteritis (EoGE) is a rare digestive disorder characterized by eosinophilic infiltration in the stomach and intestines. The endoscopic findings of EoGE in the small intestine are not well understood, but this literature review identified common findings such as redness, villous atrophy, erosion, ulceration, edema, and stenosis. These findings contribute to the development of EoGE practice.
Review
Medicine, General & Internal
Yasuhiko Abe, Yu Sasaki, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Matsuki Umehara, Yoshiyuki Ueno
Summary: Eosinophilic esophagitis is a chronic immune-mediated inflammatory disease characterized by esophageal dysfunction and intense eosinophil infiltration. The recognition of characteristic endoscopic features and subsequent biopsy are crucial for early diagnosis and treatment, but the diagnostic consistency among endoscopists is still inadequate. Image-enhanced endoscopy holds promise for improving diagnostic efficiency.
Article
Biochemistry & Molecular Biology
Shinpei Sugahara, Hiroaki Haga, Chisaki Ikeda, Naohiko Makino, Akiko Matsuda, Yasuharu Kakizaki, Kyoko Hoshikawa, Tomohiro Katsumi, Tetsuya Ishizawa, Toshikazu Kobayashi, Keita Maki, Fumiya Suzuki, Ryoko Murakami, Hidenori Sato, Yoshiyuki Ueno
Summary: Despite extensive study on liver regeneration, the impact of bile-derived extracellular vesicles (bile EVs) on hepatocytes remains unclear. Using a rat model of partial hepatectomy (PH), this study found that bile EVs released 12 hours after PH significantly promoted hepatocyte proliferation. Transcriptome analysis revealed an upregulation of genes promoting cell cycle progression in hepatocytes treated with PH24-EVs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
