Article
Biotechnology & Applied Microbiology
Amanda Marchini, Maria Gessica Ciulla, Barbara Antonioli, Alessandro Agnoli, Umberto Bovio, Virginia Visnoviz, Federico Bertuzzi, Fabrizio Gelain
Summary: Human pancreatic islets transplantation is an experimental treatment for Type I Diabetes, but limited lifespan in culture remains a challenge. This study proposes the use of self-assembling peptides to recreate a pancreatic extracellular matrix and provide mechanical and biological support to human pancreatic islets in vitro. The results show that the three-dimensional support provided by the HYDROSAP scaffold maintains islet functionality and morphology for up to 4 weeks, similar to freshly-isolated islets. Preliminary data suggests that pre-cultured islets in HYDROSAP hydrogels can restore normoglycemia in diabetic mice when transplanted.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Perry Elliott, Brian M. Drachman, Stephen S. Gottlieb, James E. Hoffman, Scott L. Hummel, Daniel J. Lenihan, Ben Ebede, Balarama Gundapaneni, Benjamin Li, Marla B. Sultan, Sanjiv J. Shah
Summary: This study demonstrates the long-term efficacy of Tafamidis in the treatment of transthyretin amyloid cardiomyopathy, showing that patients who were initially treated with Tafamidis had significantly better survival rates than those who received placebo initially.
CIRCULATION-HEART FAILURE
(2022)
Article
Medicine, General & Internal
Giosafat Spitaleri, Elisabet Zamora, German Cediel, Pau Codina, Evelyn Santiago-Vacas, Mar Domingo, Josep Lupon, Javier Santesmases, Crisanto Diez-Quevedo, Maria Isabel Troya, Maria Boldo, Salvador Altimir, Nuria Alonso, Beatriz Gonzalez, Antoni Bayes-Genis
Summary: Differences in long-term all-cause and cardiovascular mortality in heart failure outpatients were assessed based on the etiology of heart failure. Dilated cardiomyopathy had the lowest risk of all-cause death, while drug-induced cardiomyopathy had the highest risk. However, almost all etiologies had a lower risk of cardiovascular death than ischemic heart disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Joao Pedro Werneck-de-Castro, Flavia Leticia Martins Pecanha, Diego Henrique Silvestre, Ernesto Bernal-Mizrachi
Summary: mTORC1 deficiency or hyperactivation in pancreatic beta-cells can lead to diabetes. LARP1, the most abundant LARP in mouse islets and human beta-cells, is upregulated in diabetic subjects. However, genetically disrupting the Larp1 gene does not seem to have a major impact on glucose homeostasis, suggesting that LARP1 may not play a significant role in beta-cells.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Annamaria Lia, Gabriele Sansevero, Angela Chiavegato, Miriana Sbrissa, Diana Pendin, Letizia Mariotti, Tullio Pozzan, Nicoletta Berardi, Giorgio Carmignoto, Cristina Fasolato, Micaela Zonta
Summary: This study reveals that decreased calcium activity in astrocytes is associated with memory loss in a mouse model of Alzheimer's disease. Overexpression of STIM1 can restore calcium signaling and synaptic plasticity in astrocytes.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Ki-Do Eum, Trenton James Honda, Bingyu Wang, Fatemeh Kazemiparkouhi, Justin Manjourides, Vivian C. Pun, Virgil Pavlu, Helen Suh
Summary: This study examined the impact of long-term NO2 exposure on cause-specific mortality among older adults in the U.S. The results showed that increased NO2 exposure was associated with elevated mortality rates for various causes of death, raising concerns about the effectiveness of the current NAAQS for NO2.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cell Biology
Ahmed K. Elsayed, Nehad M. Alajez, Essam M. Abdelalim
Summary: Our study reveals the association between FOXA2 loss and altered lncRNA expression profile, providing novel insights into the regulatory role of lncRNA and mRNA networks in pancreatic islet development.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Raffaelle Girlanda, Jedson R. Liggett, Meth Jayatilake, Alexander Kroemer, Juan Francisco Guerra, Jason Solomon Hawksworth, Pejman Radkani, Cal S. Matsumoto, Michael Zasloff, Thomas M. Fishbein
Summary: By analyzing fecal samples from intestinal transplant recipients, we found that the microbial composition of stable intestinal transplants is similar to that of the general population, while refractory rejection patients show significant differences. Metabolomic analysis also revealed distinct metabolite clusters in rejecting recipients.
Article
Medicine, Research & Experimental
Eunbi Cho, Se Jin Jeon, Jieun Jeon, Jee Hyun Yi, Huiyoung Kwon, Hyun-Ji Kwon, Kyoung Ja Kwon, Minho Moon, Chan Young Shin, Dong Hyun Kim
Summary: Phyllodulcin, a component of hydrangea, can inhibit the aggregation of A beta and improve memory impairments in AD mice, suggesting it may be a potential treatment for AD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Ted D. Adams, Huong Meeks, Alison Fraser, Lance E. Davidson, John Holmen, Michael Newman, Anna R. Ibele, Nathan Richards, Steven C. Hunt, Jaewhan Kim
Summary: This retrospective study examined the long-term mortality outcomes of different bariatric surgery procedures and age groups. The study found that all-cause mortality was lower in the surgery group compared to the non-surgery group, with significant reductions in mortality from cardiovascular disease, cancer, and diabetes. However, the rate of death from suicide was higher in the surgery group, particularly in the youngest age group.
Article
Cardiac & Cardiovascular Systems
Christoph Ahlgrim, Florian Seiler, Philipp Birkner, Simon Schoechlin, Sebastian Grundmann, Christoph Bode, Torben Pottgiesser
Summary: This study found that PV expansion is a relevant predictor of long-term all-cause mortality in compensated CHF patients. PV expansion can be identified through hematocrit values, and it is unclear whether it can be targeted with diuretic therapy.
CLINICAL CARDIOLOGY
(2022)
Article
Oncology
Filippo Pelizzaro, Alessandro Vitale, Anna Sartori, Andrea Vieno, Barbara Penzo, Francesco Paolo Russo, Anna Chiara Frigo, Edoardo G. Giannini, Manuela Piccinnu, Gian Ludovico Rapaccini, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Rodolfo Sacco, Ciro Celsa, Fabio Marra, Andrea Mega, Maria Guarino, Antonio Gasbarrini, Gianluca Svegliati-Baroni, Francesco Giuseppe Foschi, Andrea Olivani, Alberto Masotto, Pietro Coccoli, Giovanni Raimondo, Francesco Azzaroli, Gianpaolo Vidili, Maurizia Rossana Brunetto, Franco Trevisani, Fabio Farinati
Summary: Surveillance significantly impacts long-term survival in HCC patients, leading to earlier diagnosis and increased potential for curative treatments. Implementing widespread surveillance programs is crucial for improving the prognosis of HCC patients.
Article
Gastroenterology & Hepatology
Satish Munigala, Sami Almaskeen, Divya S. Subramaniam, Sriya Bandi, Benjamin Bowe, Hong Xian, Sunil G. Sheth, Thomas E. Burroughs, Banke Agarwal
Summary: In this study, the researchers investigated the long-term risk of pancreatic ductal adenocarcinoma (PDAC) after acute pancreatitis (AP) and its association with the etiology of AP, recurrence frequency, and progression to chronic pancreatitis (CP). Their findings indicate a higher PDAC risk 3-10 years after AP, independent of the etiology, and this risk increases with the number of AP episodes and is additive to the risk associated with CP.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Environmental Sciences
Edward Tipping, Jessica A. C. Davies, Peter A. Henrys, Susan G. Jarvis, Simon M. Smart
Summary: The study model shows that plant species richness in British semi-natural ecosystems has undergone significant changes over the past centuries, mainly influenced by the deposition of N-dep and S-dep, as well as soil pH and net primary productivity. Over the past two centuries, the average species loss reached 39%, but in recent years, there has been an increase in plant species richness due to reductions in S-dep and increases in soil pH, although there are also indications of recent slight recovery from the eutrophying effects of N-dep.
ENVIRONMENTAL POLLUTION
(2021)
Article
Neurosciences
Sabrina Chierzi, J. Benjamin Kacerovsky, Albert H. K. Fok, Sylvie Lahaie, Arielle Shibi Rosen, W. Todd Farmer, Keith K. Murai
Summary: Immature cortical astrocytes can integrate, mature, and survive following transplantation and retain their astrocytic properties. This study provides insights into the development and diversity mechanisms of astrocytes and the optimal timing for astrocyte transplantation in regenerative medicine.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Pathology
Marie E. Oskarsson, Johan F. Paulsson, Sebastian W. Schultz, Martin Ingelsson, Per Westermark, Gunilla T. Westermark
AMERICAN JOURNAL OF PATHOLOGY
(2015)
Article
Pharmacology & Pharmacy
Bo Xu, Silvana Vasile, Soren Ostergaard, Johan F. Paulsson, Jasna Pruner, Johan Aqvist, Birgitte S. Wulff, Hugo Gutierrez-de-Teran, Dan Larhammar
MOLECULAR PHARMACOLOGY
(2018)
Article
Endocrinology & Metabolism
Simona I. Chisalita, Torbjorn Lindstrom, Par Eson Jennersjo, Johan F. Paulsson, Gunilla T. Westermark, Anders G. Olsson, Hans J. Arnqvist
ACTA DIABETOLOGICA
(2009)
Article
Biochemistry & Molecular Biology
Johan F. Paulsson, Marie-Odile Benoit-Biancamano, Lauge Schaffer, Kirsten Dahl
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2011)
Article
Biochemistry & Molecular Biology
Ehud Cohen, Johan F. Paulsson, Pablo Blinder, Tal Burstyn-Cohen, Deguo Du, Gabriela Estepa, Anthony Adame, Hang M. Pham, Martin Holzenberger, Jeffery W. Kelly, Eliezer Masliah, Andrew Dillin
Article
Chemistry, Medicinal
Louise Albertsen, Soren Ostergaard, Johan F. Paulsson, Jens Chr. Norrild, Kristian Stromgaard
Article
Endocrinology & Metabolism
Johan F. Paulsson, SebastianW. Schultz, Martin Kohler, Ingo Leibiger, Per-Olof Berggren, Gunilla T. Westermark
EXPERIMENTAL DIABETES RESEARCH
(2008)
Article
Neurosciences
Andrew O. Koob, Kiren Ubhi, Johan F. Paulsson, Jeffery Kelly, Edward Rockenstein, Michael Mante, Anthony Adame, Eliezer Masliah
EXPERIMENTAL NEUROLOGY
(2010)
Article
Biochemistry & Molecular Biology
Soren L. Pedersen, Vikram K. Bhatia, Simon Jurt, Johan F. Paulsson, Maria H. Pedersen, Rasmus Jorgensen, Birgitte Holst, Dimitrios Stamou, Niels Vrang, Oliver Zerbe, Knud J. Jensen
JOURNAL OF PEPTIDE SCIENCE
(2012)
Article
Multidisciplinary Sciences
Johan F. Paulsson, Johnny Ludvigsson, Annelie Carlsson, Rosaura Casas, Gun Forsander, Sten A. Ivarsson, Ingrid Kockum, Ake Lernmark, Claude Marcus, Bengt Lindblad, Gunilla T. Westermark
Article
Multidisciplinary Sciences
Kenji Usui, John D. Hulleman, Johan F. Paulsson, Sarah J. Siegel, Evan T. Powers, Jeffery W. Kelly
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Multidisciplinary Sciences
Kayalvizhi Madhivanan, Erin R. Greiner, Miguel Alves-Ferreira, David Soriano-Castell, Nirvan Rouzbeh, Carlos A. Aguirre, Johan F. Paulsson, Justin Chapman, Xin Jiang, Felicia K. Ooi, Carolina Lemos, Andrew Dillin, Veena Prahlad, Jeffery W. Kelly, Sandra E. Encalada
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Virology
Andrew M. Lee, Johan F. Paulsson, Justin Cruite, Abegail A. Andaya, Matthew J. Trifilo, Michael B. A. Oldstone
Article
Chemistry, Medicinal
Louise Albertsen, Julie J. Andersen, Johan F. Paulsson, Jens K. Thomsen, Jens C. Norrild, Kristian Stromgaard
ACS MEDICINAL CHEMISTRY LETTERS
(2013)