Editorial Material
Cell Biology
Renzhi Hou, Aliaksandr A. Astrowski, Maksim V. Plikus
Summary: The heightened ability of spiny mice to regenerate after injury is attributed to molecular changes in the Hippo-YAP pathway that protect wound fibroblasts from a persistent contractile state, as revealed in this issue of Developmental Cell.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Rakan Naboulsi, Jakub Cieslak, Denis Headon, Ahmad Jouni, Juan J. Negro, Goran Andersson, Gabriella Lindgren
Summary: Gene expression differences can help understand important genetic mechanisms between phenotypic traits. Choosing an appropriate sample collection method can enhance the specificity of results. In this study, RNA-seq was performed on plucked-hair and skin biopsy samples, and cell-type enrichment was compared between the two methods using cell-specific marker genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jinmei Wang, Xiaoxiao Wang, Jundong Xie, Bin Yao, Miaohua Mo, Danjun Ma, Chen Huang, Renhe Xu, Xiaobing Fu, Edward E. Tredget, Yaojiong Wu
Summary: SKPs can serve as the hair-inductive cells in engineered skin substitutes, providing them with the potential for hair follicle regeneration.
Review
Endocrinology & Metabolism
Alec Sevilla, Jeremy Cheret, Radomir M. Slominski, Andrzej T. Slominski, Ralf Paus
Summary: Melatonin, an evolutionarily ancient compound, plays a crucial role in regulating melanogenesis, oxidative biology, mitochondrial function, and pigmentation-related clock gene activity in human skin. It inhibits melanogenesis and melanocyte proliferation by stimulating melatonin membrane receptors, while also providing cyto- and senescence-protective and antioxidative effects in melanocytes. Research suggests the importance of studying melatonin's effects on melanocytes in a physiological tissue context and further exploring its impact on human epidermis and hair follicles.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Dermatology
Nathaniel B. Goldstein, Andrea Steel, Chauncey C. Barbulescu, Maranke Koster, Michael J. Wright, Kenneth L. Jones, Bifeng Gao, Brian Ward, Brian Woessner, Zachary Trottier, Jen Pakieser, Junxiao Hu, Karoline A. Lambert, Yiqun G. Shellman, Mayumi Fujita, William A. Robinson, Dennis R. Roop, David A. Norris, Stanca A. Birlea
Summary: The study revealed the pathways and signals in the bulge that control repigmentation in human vitiligo. Through selective capture and RNA-sequencing of cells from the hair follicle bulge, it was found that signals like KCTD10, CTNNB1, and RHO play a role in repigmentation, laying the foundation for the discovery of molecules that induce robust repigmentation in vitiligo.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Paula M. M. Oliveira, Thuany Alencar-Silva, Felipe Q. Q. Pires, Marcilio Cunha-Filho, Tais Gratieri, Juliana Lott M. Carvalho, Guilherme M. Gelfuso
Summary: This study aimed to develop a safe formulation based on nanostructured lipid carriers (NLC) that can deliver minoxidil and latanoprost to the hair follicles. The results showed that the NLC effectively encapsulated the drugs, penetrated into the hair follicles, and demonstrated good tolerance.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biology
ZhiCao Yue, Mingxing Lei, Ralf Paus, Cheng-Ming Chuong
Summary: The regulatory logic in organ regeneration, including quantitative thresholds and qualitative responses, is crucial for understanding the initiation and completion of the process. Examples in skin regeneration highlight the significance of molecular regulatory circuitry, and knowledge of this logic may lead to novel therapeutic strategies.
BIOLOGICAL REVIEWS
(2021)
Article
Chemistry, Medicinal
Anna Runnsjo, Susanna Liljedahl, David Sagna, Maria Ekblad, Jan Alenfall
Summary: This study aimed to develop a cosmetic formulation that enables peptide follicular permeation with chemical and physical stability and compatibility with the skin and sebum. By keeping the peptide in solid form and in a water-free environment, reducing the particle size to < 10 μm, and formulating the peptide with sebum-compatible excipients, a safe and cosmetically attractive formulation was successfully developed for the local distribution of the model peptide into the skin.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alok Jaiswal, Raghvendra Singh
Summary: This study investigates the role of the Notch signaling pathway in hair follicle and epidermal homeostasis. Loss of Notch signaling leads to the development of BCC and drug resistance in BCC cells.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Cell Biology
Chinnavuth Vatanashevanopakorn, Thanutchaporn Sartyoungkul
Summary: Hair follicles are involved in a variety of functions and their formation and cycling require interaction between different cell types. Despite extensive research, generating functional human hair follicles for clinical use remains a challenge. Human pluripotent stem cells offer a promising unlimited cell source for generating hair follicle cells. This review discusses hair follicle morphogenesis, different cell sources for regeneration, and potential strategies using induced pluripotent stem cells for hair follicle bioengineering. Challenges and perspectives for using bioengineered hair follicles in treating hair loss disorders are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yijie Zhang, Enhejirigala, Zhao Li, Wei Song, Bin Yao, Jianjun Li, Yuzhen Wang, Xianlan Duan, Xingyu Yuan, Sha Huang, Xiaobing Fu
Summary: The restoration of regenerative capacity of hair follicles through the use of plantar dermis matrix homogenate (PD) and the role of CTHRC1 in this process have been highlighted in the study. PD was found to be an effective microenvironmental cue for restoring hair follicle regenerative capacity, while CTHRC1 played a significant role in hair follicle regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Lisette Van Hove, Annagiada Toniolo, Mohammad Ghiasloo, Kim Lecomte, Fleur Boone, Maarten Ciers, Kris Raaijmakers, Niels Vandamme, Jana Roels, Sophia Maschalidi, Kodi S. Ravichandran, Maria Kasper, Geert van Loo, Esther Hoste
Summary: In this study, the authors show that keratinocyte-specific deletion of Atg16l1 exacerbates skin inflammatory and tumorigenic responses. They also demonstrate that keratinocyte autophagy regulates the activation of hair follicle stem cells (HFSCs) and impacts skin healing. These findings suggest that autophagy in keratinocytes plays a crucial role in controlling skin inflammation, tumorigenesis, and HFSC activation.
Article
Multidisciplinary Sciences
Ritesh K. Srivastava, Yong Wang, Jasim Khan, Suhail Muzaffar, Madison B. Lee, Zhiping Weng, Claire Croutch, Anupam Agarwal, Jessy Deshane, Mohammad Athar
Summary: This study investigated the pathobiology of arsenical compounds in two mouse models and found that they caused skin inflammation, blistering, and necrosis, accompanied by increased cytokines and proinflammatory mediators. The presence or absence of hair follicles did not significantly affect the qualitative inflammatory response, but the levels of cytokines and chemokines differed between the two strains. The mechanisms of inflammation were similar, involving reactive oxygen species induction and unfolded protein response signaling.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Engineering, Biomedical
Chew Teng Tan, Zhenn Yi Leo, Chin Yan Lim
Summary: This study presents a method for generating human artificial skin constructs containing hair follicles, which induced the formation of invaginating structures resembling follicles. By optimizing the culture conditions and media combination, the researchers successfully generated spheroids expressing hair follicle lineage genes and incorporated them into epidermal-dermal constructs for long-term growth and maturation.
BIOMEDICAL MATERIALS
(2022)
Review
Biology
Marie-Claire Mechin, Michel Simon
Summary: This article discusses the role of peptidylarginine deiminases (PADs) in physiological processes and their involvement in human diseases. PAD1 and PAD3 are important for keratinocyte differentiation and epidermal barrier function, while mutations in the PADI3 gene are associated with hair disorders and alopecia. The study highlights the significance of PADs in skin health and disease.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
