Article
Biochemistry & Molecular Biology
Zheng Kou, Balun Li, Aili Aierken, Ning Tan, Chenchen Li, Miao Han, Yuanxiang Jing, Na Li, Shiqiang Zhang, Sha Peng, Xianjun Zhao, Jinlian Hua
Summary: The existing treatment modalities for skin injuries, such as dressings, negative-pressure wound treatment, autologous skin grafting, and high-pressure wound treatment, have limitations such as high time cost and inability to remove inactivated tissue in a timely manner. Mesenchymal stem cells (MSCs) have great potential in cell therapy and regenerative medicine due to their unique self-renewal ability and differentiation potential. The addition of collagen to cell cultures promotes cell proliferation and accelerates the healing of skin wounds in mice and canines by promoting epidermal layer repair, collagen deposition, hair follicle angiogenesis, and an inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Emergency Medicine
Haiyue Ren, Feng Zhao, Qiqi Zhang, Xing Huang, Zhe Wang
Summary: The article discusses the role of autophagy in wound healing, including its anti-infection and inflammation regulatory functions in the inflammatory phase, its promotion of cell survival, angiogenesis, and cell differentiation in the proliferative phase, and its impact on hypertrophic scar formation in the remodeling phase. The article also highlights the association between autophagy and refractory diabetic wounds, and suggests that understanding autophagy regulation and molecular mechanisms can provide novel strategies for wound healing treatment.
Article
Engineering, Biomedical
Zhengbo Wen, Yuxin Chen, Peilin Liao, Fengyu Wang, Weiping Zeng, Shoupei Liu, Haibing Wu, Ning Wang, Lorenzo Moroni, Minmin Zhang, Yuyou Duan, Honglin Chen
Summary: In this study, an in situ cell electrospinning system was developed as an attractive approach for stem cell delivery, which could promote cutaneous wound healing through direct deposition of bioactive fish gelatin fibers and MSCs onto wound sites, leading to a synergistic therapeutic effect.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Immunology
Min Jiang, Xupin Jiang, Hongmei Li, Can Zhang, Ze Zhang, Chao Wu, Junhui Zhang, Jiongyu Hu, Jiaping Zhang
Summary: Diabetic foot is a common complication of diabetes and often leads to amputation. Previous studies have shown that stem cell transplantation can promote the healing of chronic diabetic wounds, but safety concerns have limited its clinical application. Recently, it has been discovered that mesenchymal stem cell-derived extracellular vesicles (EVs) have similar therapeutic effects and offer advantages such as safety and reduced immune response. This paper summarizes the current understanding of mesenchymal stem cell-derived EVs in accelerating the healing of diabetic wounds and their potential clinical applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Ning Zeng, Hongbo Chen, Yiping Wu, Zeming Liu
Summary: Wound healing in the human body is a complex physiological regulation mechanism, with adipose stem cells playing an important role in regenerative medicine. Adipose stem cells are easy to obtain, high-yielding, rich in components and cytokines, and highly practical.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Dermatology
Mohammad Bagher Heydari, Zahra Ghanbari-Movahed, Maryam Heydari, Mohammad Hosein Farzaei
Summary: This systematic review provides an overview of the application of MSC-conditioned media in skin wound healing. By analyzing relevant papers, the efficacy of MSC-conditioned media in vitro models is highlighted, providing guidance for further clinical studies.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Engineering, Biomedical
Yanqun Li, Dongyu Liu, Fengming Tan, Wenling Yin, Zhihuan Li
Summary: Mesenchymal stem cells (MSCs) combined with biological scaffolds, such as gelatin methacrylate (GelMA), can promote cell migration and proliferation and accelerate wound healing. This study focused on the application of GelMA-loaded umbilical cord MSCs (UC-MSCs) in wound healing and found positive effects on fibroblast proliferation, wound healing promotion, collagen deposition, and angiogenesis.
BIOMEDICAL MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Dharshan Sivaraj, Kellen Chen, Arhana Chattopadhyay, Dominic Henn, Wanling Wu, Chikage Noishiki, Noah J. Magbual, Smiti Mittal, Alana M. Mermin-Bunnell, Clark A. Bonham, Artem A. Trotsyuk, Janos A. Barrera, Jagannath Padmanabhan, Michael Januszyk, Geoffrey C. Gurtner
Summary: Cutaneous wounds are becoming a growing global health burden due to an aging population and increasing incidence of diseases. Cell therapy combined with hydrogels shows potential in improving treatment efficacy for wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Golnaz Mahmoudvand, Arian Karimi Rouzbahani, Zahra Sadat Razavi, Mohamad Mahjoor, Hamed Afkhami
Summary: Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus (DM) that can lead to amputation. The wound-healing process is impaired in diabetic patients, making conventional treatments ineffective. Mesenchymal stem cells (MSCs) have gained attention for their potential in improving wound healing. MSC therapy improves healing in DFU through immunomodulation, differentiation, and angiogenesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiao-Fei Zhang, Ting Wang, Zi-Xuan Wang, Kun-Peng Huang, Yun-Wei Zhang, Guo-Liang Wang, Hong-Ji Zhang, Zi-Han Chen, Chang-Yan Wang, Jin-Xiang Zhang, Hui Wang
Summary: In a hypoxic microenvironment, ucMSCs enhance endothelial cell proliferation and migration through exosome-mediated paracrine function, accelerating wound healing. miR-125b in hypoxic exosomes targets and suppresses TP53INP1, alleviating hypoxia-induced cell apoptosis and promoting cutaneous repair.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Materials Science, Biomaterials
Jia-Lin Liu, De-Lai Kang, Peng Mi, Cheng-Zhi Xu, Lian Zhu, Ben-Mei Wei
Summary: A skin wound is a rupture caused by external damage or underlying pathological conditions, and wound healing processes can be burdensome. Bacterial infection, inflammation, impaired angiogenesis, and scar formation hinder the recovery of skin wounds. Scientists are developing multifunctional nanomedicines to address these challenges. Mesenchymal stem cells (MSCs) have been explored for wound repair due to their self-renewal and multipotency, but immune concerns and legal restrictions need to be resolved. MSC-derived extracellular vesicles (EVs) are promising therapeutics for wound repair, possessing advantages such as abundant sources and convenient administration routes. However, current reviews lack focus on the specific roles of EVs in different stages of wound healing, making it necessary to highlight the significance of MSC-derived EVs in promoting wound healing. This review discusses the advances of MSC-derived EVs in wound repair, particularly their roles in eliminating infections, reducing inflammation, promoting angiogenesis, and minimizing scar formation. The limitations and future prospects of MSC-derived EVs in wound repair are also objectively analyzed.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yunchuan Wang, Yue Zhang, Ting Li, Kuo Shen, Ke Jia Wang, Chenyang Tian, Dahai Hu
Summary: Engineered skin substitutes derived from human skin reduce inflammatory reactions and are easier to use in clinics. Type I collagen and platelet-rich plasma are mixed to form a stable scaffold, while adipose mesenchymal stem cell derived exosomes improve the performance of the engineered skin. This method provides a new therapeutic strategy and theoretical basis for tissue regeneration and wound repair.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Filip Humenik, Jan Danko, Lenka Kresakova, Katarina Vdoviakova, Vladimir Vrabec, Emilia Vasilova, Maria Giretova, Stefan Toth, Zuzana Fagova, Jan Babik, Lubomir Medvecky
Summary: The aim of this study is to investigate the beneficial treatment effect of a novel chitosan bio-polymeric material enriched with mesenchymal stem cell products derived from the canine adipose tissue (AT-MSC) on artificial skin defects. Histological analysis and scoring system were used to evaluate the regeneration process, showing accelerated and improved healing in the treatment group compared to the negative control. Additionally, the chitosan-based biomaterial also promoted hair follicle and epidermis layer formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jieun Kim, Eun Hee Kim, Hanbee Lee, Ji Hee Sung, Oh Young Bang
Summary: We developed a bioprocessing platform for large-scale production of human Wharton's jelly MSC-derived EVs. The effects of clinical-scale MSC-EV products on wound healing were tested in two different wound models. In vivo efficacy tests showed that treatment with MSC-EVs improved wound recovery, regardless of the type of wound model or treatment mode. In vitro mechanistic studies demonstrated that EV therapy contributed to all stages of wound healing, enhancing re-epithelialization, extracellular matrix remodeling, and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nanoscience & Nanotechnology
Ming Zhao, Jihong Shi, Weixia Cai, Kaituo Liu, Kuo Shen, Zichao Li, Yunchuan Wang, Dahai Hu
Summary: Graphene and its derivatives, along with mesenchymal stem cell-exosomes, show promise in the development of novel wound dressings and cell-free treatment for wound healing. Further studies are needed to understand the mechanisms of action and to promote their clinical transformation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Dermatology
Chika Ohata, Bungo Ohyama, Aya Nanri, Takako Shintani, Takekuni Nakama
JOURNAL OF DERMATOLOGICAL TREATMENT
(2019)
Article
Dermatology
Chika Ohata, Hiroshi Koga, Hiroshi Saruta, Norito Ishii, Takekuni Nakama
JOURNAL OF DERMATOLOGICAL TREATMENT
(2019)
Article
Dermatology
Chika Ohata, Bungo Ohyama, Fumi Kuwahara, Eri Katayama, Takekuni Nakama
JOURNAL OF DERMATOLOGICAL TREATMENT
(2019)
Article
Dermatology
Yuichi Kurihara, Jun Yamagami, Takeru Funakoshi, Maki Ishii, Julia Miyamoto, Yumi Fujio, Risa Kakuta, Akiko Tanikawa, Yumi Aoyama, Keiji Iwatsuki, Norito Ishii, Takashi Hashimoto, Wataru Nishie, Hiroshi Shimizu, Keisuke Kouyama, Masayuki Amagai
JOURNAL OF DERMATOLOGY
(2019)
Article
Dermatology
Chika Ohata, Bungo Ohyama, Eri Katayama, Takekuni Nakama
JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Takushi Shirai, Yukiko Kiniwa, Norito Ishii, Takashi Hashimoto, Yasushi Senoo, Kazuhisa Urushihata, Atsuko Ashida, Ryuhei Okuyama
JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Kaori Kaibuchi-Ando, Kazumitsu Sugiura, Yoshinao Muro, Yoshiyuki Takahashi, Seiji Kojima, Norito Ishii, Takashi Hashimoto, Masashi Akiyama
JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Chika Ohata, Yuri Shimizu, Misa Hayashi
JOURNAL OF DERMATOLOGY
(2020)
Article
Dermatology
Chika Ohata, Noriko Tsuruta, Kentaro Yonekura, Yuko Higashi, Kanami Saito, Eri Katayama, Shinichi Imafuku
Summary: Generalized pustular psoriasis (GPP) is a rare and severe subtype of psoriasis that predominantly affects females with lower body mass index and lesser rates of alcohol consumption. The study identified different types of GPP, age at onset, and precipitating factors, shedding light on the demographics and characteristics of patients with GPP.
JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Kazuya Akaji, Yoko Imanaka, Chika Ohata
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Dermatology
Ami Kawaguchi, Mitsuhiro Matsuda, Hiroshi Koga, Chika Ohata, Takahiro Hamada, Hiroyuki Mishima, Koh-ichiro Yoshiura, Masatoshi Jinnin, Hironori Minami, Nobuo Kanazawa
Summary: We report a case of Darier's disease in a mother and her adult son. The mother had positivity for anti-Dsg1 antibodies, while the son did not. Genetic analysis revealed a mutation in the Atp2a2 gene in both patients.
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Masaru Honma, Yasumasa Kanai, Kenta Murotani, Kei Ito, Chika Ohata, Fumikazu Yamazaki, Hidehisa Saeki, Mariko Seishima, Yoko Mizutani, Hiroki Kitabayashi, Shinichi Imafuku
Summary: This study assessed the effectiveness of brodalumab treatment on itching and skin pain in Japanese patients with psoriasis. The results showed that brodalumab treatment significantly improved itching and skin pain symptoms.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Tetsuji Yanase, Noriko Tsuruta, Kazuki Yamaguchi, Chika Ohata, Bungo Ohyama, Eri Katayama, Kazunari Sugita, Maki Kuwashiro, Aki Hashimoto, Kentaro Yonekura, Yuko Higashi, Hiroyuki Murota, Yuta Koike, Yuki Matsuzaka, Satoko Kikuchi, Yutaka Hatano, Kanami Saito, Kenzo Takahashi, Takuya Miyagi, Sakae Kaneko, Masataka Ota, Kayo Harada, Shin Morizane, Kenta Ikeda, Masutaka Furue, Takeshi Nakahara, Fusako Okazaki, Natsuko Sasaki, Etsuko Okada, Yuichi Yoshida, Kotaro Ito, Shinichi Imafuku
Summary: This study investigated the real-world survival rate of systemic interventions for psoriasis treatment and found differences in the efficacy of biologics. The factors that negatively impact the survival rate of biologics include previous use of biologics, obesity, and psoriatic arthritis.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Chika Ohata, Yasumasa Kanai, Kenta Murotani, Fumikazu Yamazaki, Hidetoshi Takahashi, Yayoi Tada, Tomotaka Mabuchi, Yoko Mizutani, Takanobu Nomura, Shinichi Imafuku
Summary: The study aimed to assess the effectiveness of brodalumab on self-assessed anxiety and depressive symptoms in Japanese patients with psoriasis. The results showed that brodalumab treatment significantly reduced anxiety symptoms, but had limited effect on depressive symptoms. Therefore, patients with psoriasis and depressive symptoms may require long-term treatment.
DERMATOLOGY AND THERAPY
(2023)
Letter
Dermatology
Takahiro Ishikawa, Takichi Munetsugu, Yui Shinada, Yuiko Yonekura, Norihiro Fujimoto, Norito Ishii, Takashi Hashimoto, Takahiro Satoh
EUROPEAN JOURNAL OF DERMATOLOGY
(2019)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
