Journal
EXPERIMENTAL DERMATOLOGY
Volume 21, Issue 6, Pages 463-466Publisher
WILEY
DOI: 10.1111/j.1600-0625.2012.01502.x
Keywords
epidermolysis bullosa; multiple-locus variable number of tandem repeats analysis; nasal colonization; spa typing; Staphylococcus aureus; wound colonization
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Patients with the blistering disease, epidermolysis bullosa (EB), frequently suffer from chronic wounds that become colonized by pathogenic bacteria, such as Staphylococcus aureus. To determine S.similar to aureus colonization rates in patients with EB, swabs were collected from the anterior nares, throats and wounds of 52 Dutch patients with EB. Swabs were also collected from nares and throats of 13 healthcare workers who occasionally meet the sampled patients with EB. All EB patients with chronic wounds and 75% of the patients without chronic wounds were colonized with S.similar to aureus. In contrast, 39% of the sampled healthcare workers were colonized with S.similar to aureus. Typing revealed a high degree of genetic diversity of 184 collected S.similar to aureus isolates. Autoinoculation of S.similar to aureus in individual patients with EB was shown to occur frequently, whereas transmission of S.similar to aureus between patients with EB is apparently rare. There was no evidence for S.similar to aureus transmission between patients with EB and healthcare workers.
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