Article
Immunology
Pierre-Louis Herve, Camille Plaquet, Noemie Assoun, Nathalie Oreal, Laetitia Gaulme, Audrey Perrin, Adeline Bouzereau, Veronique Dhelft, Jean-Louis Labernardiere, Lucie Mondoulet, Hugh A. Sampson
Summary: Skin, rich in antigen presenting cells, is a promising route for immunotherapy and vaccination. A study using mouse models shows that preexisting specific-IgG antibodies play a crucial role in capturing allergens by skin dendritic cells through the involvement of antigen-specific IgG-Fc gamma R. The research sheds light on the mechanisms of allergen capture and migration in the skin.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Cakala-Jakimowicz, Monika Puzianowska-Kuznicka
Summary: In individuals with lymphedema, diabetic foot, or other diseases, infections with saprophytes are common. This study assessed the response of major cell subpopulations in the draining lymph nodes to skin infection with Staphylococcus epidermidis using the rat model. The results showed changes in cell subpopulations and demonstrated the efficient elimination of the administered antigen. Understanding how the lymph nodes eliminate S. epidermidis can provide valuable insights into creating immunological therapies against saprophyte infections.
Review
Immunology
Philipp R. R. Esser, Michael Huber, Stefan F. F. Martin
Summary: Maintaining homeostasis is crucial for organismal health. The innate immune system and the unfolded protein response play important roles in inflammation and inflammatory diseases, including allergic contact dermatitis. This review explores the interplay between the innate immune system and cellular stress responses, focusing on the unfolded protein response.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Edries Yousaf Hajam, Patricia Panikulam, Chung-Ching Chu, Haarshadri Jayaprakash, Amitabha Majumdar, Colin Jamora
Summary: As the interface between the body and the environment, the skin not only acts as a physical barrier, but also as an immunologically active organ. Regulatory T cells (T-regs) play a crucial role in maintaining homeostasis, clearing pathogens, and promoting wound healing. Recent studies have uncovered non-lymphoid functions of cutaneous T-regs, suggesting that they have executive control over various biological activities in the skin. These findings highlight the importance of T-regs and their potential role in future discoveries in the field of regenerative medicine.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Francesco De Virgiliis, Valeria Maria Oliva, Burak Kizil, Christoph Scheiermann
Summary: The nervous system communicates with immune cells through neurotransmitters and neuropeptides to respond to immune threats and maintain system homeostasis. Lymph nodes, as the sites of adaptive immune responses, are extensively innervated by peripheral nerves that secrete neurotransmitters and neuropeptides. Time-dependent fluctuations in nerve activity may play a role in coordinating immunity in a circadian fashion.
TRENDS IN NEUROSCIENCES
(2022)
Review
Immunology
Arnolda Jakovija, Tatyana Chtanova
Summary: The skin, as the body's largest organ, serves as a barrier to pathogens and the first line of immune defense. In the event of skin injury, a series of events contribute to wound repair, including inflammation, tissue formation, and tissue remodeling. Immune cells in the skin work alongside non-immune cells to clear pathogens, debris, and guide tissue regeneration. Disruption to the wound repair process can lead to chronic inflammation and non-healing wounds, which can promote skin cancer development by hijacking the wound healing response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Marie-Ange Dagnelie, Stephane Corvec, Elise Timon-David, Amir Khammari, Brigitte Dreno
Summary: Skin microbiota plays a crucial role in inflammatory skin response, and maintaining a balance between bacterial communities is essential. Imbalance in skin microbiota can activate inflammation-related markers, especially with S. epidermidis having a more significant impact on IL-6 induction.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Nutrition & Dietetics
Fritzlaine C. Roche, Tamia A. Harris-Tryon
Summary: Vitamin A is crucial for skin immunity, deficiencies can lead to impaired immune response and increased susceptibility to skin infections. Recent evidence shows that vitamin A and its derivatives play a role in innate immune regulation by promoting skin immunity and sustaining the skin microbiome.
Article
Medicine, Legal
David W. Roberts, Ian Kimber, David A. Basketter
Summary: This paper finds that the apparent reduced specificity of the LLNA largely reflects differences in definitions of the boundaries between weak skin sensitisers and non-sensitisers. A small number of LLNA false positives may be due to lymphocyte proliferation without skin sensitisation, but most alleged 'false' positives are in fact very weak sensitisers predictable from structure-activity considerations. The evidence does not support the hypothesis for hydrophobicity-induced false positives. Moreover, the mechanistic basis is untenable. Sound LLNA data, appropriately interpreted, remain a good measure of sensitisation potency, applicable across a wide hydrophilicity-hydrophobicity range.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Immunology
Sandra Vreman, Johanna M. J. Rebel, Joanne McCaffrey, Kristina Ledl, Ksenia Arkhipova, Damien Collins, Dennis McDaid, Huub F. J. Savelkoul, Kerstin Skovgaard, Anne C. Moore, Norbert Stockhofe-Zurwieden
Summary: This study investigated the immune-stimulatory potential of different Toll-like receptor agonists (TLRa) in neonatal and adult pigs vaccinated in the skin using dissolving microneedle patches. The results showed that TLR7/8a induced the most prominent early inflammatory and immune cell responses, particularly in the skin. There were age-dependent differences in the upregulation of immune response related genes between neonatal and adult pigs after vaccination.
Article
Immunology
Alice Hamilton, Raffaella Rizzo, Samuel Brod, Masahiro Ono, Mauro Perretti, Dianne Cooper, Fulvio D'Acquisto
Summary: Social isolation has a significant impact on the immune regulation of mice, enhancing their resistance to bacterial infection. Social housing and huddling behavior may be important factors in regulating the host immune response.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Medicine, Legal
Andreas Natsch, Nicole Kleinstreuer, David Asturiol
Summary: Meaningful and accurate reference data are crucial for validating New Approach Methodologies (NAMs) in the field of toxicology. Multiple reference datasets are available for skin sensitization, including human patch test data, guinea pig data, and data from the mouse local lymph node assay (LLNA). However, it has been found that the LLNA shows reduced sensitivity for lipophilic chemicals with a LogP >= 3.5, leading to reliability restrictions within the h-CLAT OECD test guideline. This study suggests that the validation of NAMs in this LogP range should not solely rely on LLNA data and calls for a more comprehensive evaluation of reference data.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Immunology
Wenny Santaniemi, Pirjo Astrom, Virpi Glumoff, Nora Pernaa, Ella-Noora Tallgren, Sanna Palosaari, Antti Nissinen, Meri Kaustio, Outi Kuismin, Janna Saarela, Katariina Nurmi, Kari K. Eklund, Mikko R. J. Seppanen, Timo Hautala
Summary: In this study, the impact of a heterozygous NFKB1 c.C936T/p.R157X LOF variant on immunity in sterile fasciitis patients and their family members was explored. The variant resulted in reduced p50 or p105 protein levels and elevated IL-1 beta and IL-8 levels, potentially contributing to the high neutrophil counts observed during fasciitis episodes. The variant also led to reduced phosphorylation of p65/RelA in neutrophils, suggesting defective activation of canonical NF-kappa B, and compromised oxidative burst following activation of NF-kappa B-dependent mechanisms.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Oncology
Holden T. Maecker
Summary: Understanding the interaction of SARS-CoV-2 infection with the host immune system, induction of antibody and T cell responses, importance of innate immune responses, and impact of baseline immune profiles and changes on predicting disease progression are crucial for the development of immune monitoring tools for COVID-19.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Diana Boraschi
Summary: Interleukin-1 (IL-1) is a cytokine that plays a significant role in inflammation and immune response, primarily produced by macrophages during defensive reactions. It belongs to a superfamily of structurally similar proteins and acts through binding to specific receptors on the plasma membrane of target cells. IL-1 family cytokines not only have innate immune and inflammatory effects but also appear to be involved in the development of adaptive immunity in vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
