Journal
EXPERIMENTAL DERMATOLOGY
Volume 21, Issue 4, Pages 241-248Publisher
WILEY
DOI: 10.1111/j.1600-0625.2012.01438.x
Keywords
immunosuppression; mast cells; skin cancer; ultraviolet radiation
Categories
Funding
- Cancer Institute NSW Career Development
- Universiti Putra Malaysia
- University of Sydney
- Epiderm
- [07/CDF/01-07]
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Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerging that UV may also trigger mast cell release of cutaneous tissue remodelling and pro-angiogenic factors. In this review, we will focus on the cellular and molecular mechanisms by which UV recruits and then activates mast cells to initiate and promote skin cancer development.
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